148P HexaBody-OX40: A novel Fcγ receptor crosslinking-independent OX40-targeting antibody, exhibits agonistic activity in vitro and antitumor activity in vivo

Autor: Kemper, K., Köhne, M., van der Kroef, M., Nuermberger, K.B.B., Russier, M., Zom, G., Krause, A-L., de Goeje, P., Gieseke, F., Gorlani, A., Muik, A., Guelen, L., Satijn, D., Fellermeier-Kopf, S., Ahmadi, T., Türeci, Ö., Breij, E., Sahin, U.

Publikováno v: In Immuno-Oncology and Technology December 2023 20 Supplement

Epitope mapping of monoclonal antibodies: a comprehensive comparison of different technologies.

Autor: Dang X; Pharmacokinetics, Merck & Co. Inc, Kenilworth, NJ, USA., Guelen L; Research, Aduro Biotech Europe, Oss, The Netherlands., Lutje Hulsik D; Research, Aduro Biotech Europe, Oss, The Netherlands., Ermakov G; Pharmacokinetics, Merck & Co. Inc, Kenilworth, NJ, USA., Hsieh EJ; Pharmacokinetics, Merck & Co. Inc, Kenilworth, NJ, USA., Kreijtz J; Research, Aduro Biotech Europe, Oss, The Netherlands., Stammen-Vogelzangs J; Research, Aduro Biotech Europe, Oss, The Netherlands., Lodewijks I; Research, Aduro Biotech Europe, Oss, The Netherlands., Bertens A; Research, Aduro Biotech Europe, Oss, The Netherlands., Bramer A; Research, Aduro Biotech Europe, Oss, The Netherlands., Guadagnoli M; Research, Aduro Biotech Europe, Oss, The Netherlands., Nazabal A; Medical, CovalX AG, Zürich, Switzerland., van Elsas A; Research, Aduro Biotech Europe, Oss, The Netherlands., Fischmann T; Pharmacokinetics, Merck & Co. Inc, Kenilworth, NJ, USA., Juan V; Pharmacokinetics, Merck & Co. Inc, Kenilworth, NJ, USA., Beebe A; Pharmacokinetics, Merck & Co. Inc, Kenilworth, NJ, USA., Beaumont M; Pharmacokinetics, Merck & Co. Inc, Kenilworth, NJ, USA., van Eenennaam H; Research, Aduro Biotech Europe, Oss, The Netherlands.

Publikováno v: MAbs [MAbs] 2023 Jan-Dec; Vol. 15 (1), pp. 2285285. Date of Electronic Publication: 2023 Nov 27.

Preclinical characterization and clinical translation of pharmacodynamic markers for MK-5890: a human CD27 activating antibody for cancer immunotherapy.

Autor: Guelen L; BioNovion/Aduro Biotech Europe, Oss, The Netherlands., Fischmann TO; Discovery, Preclinical and Translational Medicine, Merck & Co Inc, Kenilworth, New Jersey, USA., Wong J; Discovery, Preclinical and Translational Medicine, Merck & Co Inc, South San Francisco, California, USA., Mauze S; Discovery, Preclinical and Translational Medicine, Merck & Co Inc, South San Francisco, California, USA., Guadagnoli M; BioNovion/Aduro Biotech Europe, Oss, The Netherlands., Bąbała N; Division of Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Wagenaars J; BioNovion/Aduro Biotech Europe, Oss, The Netherlands., Juan V; Discovery, Preclinical and Translational Medicine, Merck & Co Inc, South San Francisco, California, USA., Rosen D; Discovery, Preclinical and Translational Medicine, Merck & Co Inc, South San Francisco, California, USA., Prosise W; Discovery, Preclinical and Translational Medicine, Merck & Co Inc, Kenilworth, New Jersey, USA., Habraken M; BioNovion/Aduro Biotech Europe, Oss, The Netherlands., Lodewijks I; BioNovion/Aduro Biotech Europe, Oss, The Netherlands., Gu D; Discovery, Preclinical and Translational Medicine, Merck & Co Inc, South San Francisco, California, USA., Stammen-Vogelzangs J; BioNovion/Aduro Biotech Europe, Oss, The Netherlands., Yu Y; Discovery, Preclinical and Translational Medicine, Merck & Co Inc, South San Francisco, California, USA., Baker J; Discovery, Preclinical and Translational Medicine, Merck & Co Inc, South San Francisco, California, USA., Lutje Hulsik D; BioNovion/Aduro Biotech Europe, Oss, The Netherlands., Driessen-Engels L; BioNovion/Aduro Biotech Europe, Oss, The Netherlands., Malashock D; Discovery, Preclinical and Translational Medicine, Merck & Co Inc, South San Francisco, California, USA., Kreijtz J; BioNovion/Aduro Biotech Europe, Oss, The Netherlands., Bertens A; BioNovion/Aduro Biotech Europe, Oss, The Netherlands., de Vries E; Division of Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Bovens A; Division of Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Bramer A; BioNovion/Aduro Biotech Europe, Oss, The Netherlands., Zhang Y; Clinical Development, Merck & Co Inc, Rahway, New Jersey, USA., Wnek R; Discovery, Preclinical and Translational Medicine, Merck & Co Inc, Kenilworth, New Jersey, USA., Troth S; Discovery, Preclinical and Translational Medicine, Merck & Co Inc, West Point, Pennsylvania, USA., Chartash E; Clinical Development, Merck & Co Inc, Rahway, New Jersey, USA., Dobrenkov K; Clinical Development, Merck & Co Inc, Rahway, New Jersey, USA., Sadekova S; Discovery, Preclinical and Translational Medicine, Merck & Co Inc, South San Francisco, California, USA., van Elsas A; BioNovion/Aduro Biotech Europe, Oss, The Netherlands., Cheung JK; Process Research and Development, Merck & Co Inc, Kenilworth, New Jersey, USA., Fayadat-Dilman L; Discovery, Preclinical and Translational Medicine, Merck & Co Inc, South San Francisco, California, USA., Borst J; Division of Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Beebe AM; Discovery, Preclinical and Translational Medicine, Merck & Co Inc, South San Francisco, California, USA amy.beebe@merck.com., Van Eenennaam H; BioNovion/Aduro Biotech Europe, Oss, The Netherlands.

Publikováno v: Journal for immunotherapy of cancer [J Immunother Cancer] 2022 Sep; Vol. 10 (9).

Diverse Roles of the LINC Complex in Cellular Function and Disease in the Nervous System.

Autor: Kuwako, Ken-ichiro¹ (AUTHOR) kuwako@med.shimane-u.ac.jp, Suzuki, Sadafumi¹ (AUTHOR)

Publikováno v: International Journal of Molecular Sciences. Nov2024, Vol. 25 Issue 21, p11525. 19p.

Nucleolus and centromere Tyramide Signal Amplification-Seq reveals variable localization of heterochromatin in different cell types.

Autor: Kumar, Pradeep¹ (AUTHOR), Gholamalamdari, Omid¹ (AUTHOR), Zhang, Yang² (AUTHOR), Zhang, Liguo¹ (AUTHOR), Vertii, Anastassiia³ (AUTHOR), van Schaik, Tom⁴ (AUTHOR), Peric-Hupkes, Daan⁴ (AUTHOR), Sasaki, Takayo⁵ (AUTHOR), Gilbert, David M.⁵ (AUTHOR), van Steensel, Bas⁴ (AUTHOR), Ma, Jian² (AUTHOR), Kaufman, Paul D.³ (AUTHOR), Belmont, Andrew S.^1,6,7 (AUTHOR) asbel@illinois.edu

Publikováno v: Communications Biology. 9/13/2024, Vol. 7 Issue 1, p1-18. 18p.