Discovery of hit compounds for methyl-lysine reader proteins from a target class DNA-encoded library.

Autor: Shell DJ; UNC Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Rectenwald JM; School of Medicine, Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Buttery PH; UNC Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Johnson RL; UNC Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Foley CA; UNC Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Guduru SKR; UNC Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Uguen M; UNC Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Rubiano JS; UNC Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Zhang X; UNC Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Li F; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada., Norris-Drouin JL; UNC Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Axtman M; UNC Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Brian Hardy P; UNC Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Vedadi M; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada., Frye SV; UNC Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., James LI; UNC Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Pearce KH; UNC Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: khpearce@unc.edu.

Publikováno v: SLAS discovery : advancing life sciences R & D [SLAS Discov] 2022 Dec; Vol. 27 (8), pp. 428-439. Date of Electronic Publication: 2022 Oct 19.

AD Informer Set: Chemical tools to facilitate Alzheimer's disease drug discovery.

Autor: Potjewyd FM; UNC Eshelman School of Pharmacy Division of Chemical Biology and Medicinal Chemistry Structural Genomics Consortium Chapel Hill North Carolina USA., Annor-Gyamfi JK; UNC Eshelman School of Pharmacy Division of Chemical Biology and Medicinal Chemistry Structural Genomics Consortium Chapel Hill North Carolina USA., Aubé J; UNC Eshelman School of Pharmacy Division of Chemical Biology and Medicinal Chemistry Center for Integrative Chemical Biology and Drug Discovery Chapel Hill North Carolina USA., Chu S; Department of Medicine Division of Clinical Pharmacology Indiana University School of Medicine Indianapolis Indiana USA., Conlon IL; UNC Eshelman School of Pharmacy Division of Chemical Biology and Medicinal Chemistry Center for Integrative Chemical Biology and Drug Discovery Chapel Hill North Carolina USA., Frankowski KJ; UNC Eshelman School of Pharmacy Division of Chemical Biology and Medicinal Chemistry Center for Integrative Chemical Biology and Drug Discovery Chapel Hill North Carolina USA., Guduru SKR; UNC Eshelman School of Pharmacy Division of Chemical Biology and Medicinal Chemistry Center for Integrative Chemical Biology and Drug Discovery Chapel Hill North Carolina USA., Hardy BP; UNC Eshelman School of Pharmacy Division of Chemical Biology and Medicinal Chemistry Center for Integrative Chemical Biology and Drug Discovery Chapel Hill North Carolina USA., Hopkins MD; UNC Eshelman School of Pharmacy Division of Chemical Biology and Medicinal Chemistry Center for Integrative Chemical Biology and Drug Discovery Chapel Hill North Carolina USA., Kinoshita C; Department of Laboratory Medicine and Pathology University of Washington Seattle Washington USA.; Institute for Stem Cell and Regenerative Medicine University of Washington Seattle Washington USA., Kireev DB; UNC Eshelman School of Pharmacy Division of Chemical Biology and Medicinal Chemistry Center for Integrative Chemical Biology and Drug Discovery Chapel Hill North Carolina USA., Mason ER; Department of Medicine Division of Clinical Pharmacology Indiana University School of Medicine Indianapolis Indiana USA., Moerk CT; Department of Laboratory Medicine and Pathology University of Washington Seattle Washington USA.; Institute for Stem Cell and Regenerative Medicine University of Washington Seattle Washington USA., Nwogbo F; UNC Eshelman School of Pharmacy Division of Chemical Biology and Medicinal Chemistry Center for Integrative Chemical Biology and Drug Discovery Chapel Hill North Carolina USA., Pearce KH; UNC Eshelman School of Pharmacy Division of Chemical Biology and Medicinal Chemistry Center for Integrative Chemical Biology and Drug Discovery Chapel Hill North Carolina USA., Richardson TI; Department of Medicine Division of Clinical Pharmacology Indiana University School of Medicine Indianapolis Indiana USA., Rogers DA; UNC Eshelman School of Pharmacy Division of Chemical Biology and Medicinal Chemistry Center for Integrative Chemical Biology and Drug Discovery Chapel Hill North Carolina USA., Soni DM; Department of Medicine Division of Clinical Pharmacology Indiana University School of Medicine Indianapolis Indiana USA., Stashko M; UNC Eshelman School of Pharmacy Division of Chemical Biology and Medicinal Chemistry Center for Integrative Chemical Biology and Drug Discovery Chapel Hill North Carolina USA., Wang X; UNC Eshelman School of Pharmacy Division of Chemical Biology and Medicinal Chemistry Center for Integrative Chemical Biology and Drug Discovery Chapel Hill North Carolina USA., Wells C; UNC Eshelman School of Pharmacy Division of Chemical Biology and Medicinal Chemistry Structural Genomics Consortium Chapel Hill North Carolina USA., Willson TM; UNC Eshelman School of Pharmacy Division of Chemical Biology and Medicinal Chemistry Structural Genomics Consortium Chapel Hill North Carolina USA., Frye SV; UNC Eshelman School of Pharmacy Division of Chemical Biology and Medicinal Chemistry Center for Integrative Chemical Biology and Drug Discovery Chapel Hill North Carolina USA., Young JE; Department of Laboratory Medicine and Pathology University of Washington Seattle Washington USA.; Institute for Stem Cell and Regenerative Medicine University of Washington Seattle Washington USA., Axtman AD; UNC Eshelman School of Pharmacy Division of Chemical Biology and Medicinal Chemistry Structural Genomics Consortium Chapel Hill North Carolina USA.

Publikováno v: Alzheimer's & dementia (New York, N. Y.) [Alzheimers Dement (N Y)] 2022 Apr 20; Vol. 8 (1), pp. e12246. Date of Electronic Publication: 2022 Apr 20 (Print Publication: 2022).

Discovery of small molecules targeting the tandem tudor domain of the epigenetic factor UHRF1 using fragment-based ligand discovery.

Autor: Chang L; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX, 77030, USA.; Center for Drug Discovery, Baylor College of Medicine, Houston, TX, 77030, USA., Campbell J; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX, 77030, USA.; Center for Drug Discovery, Baylor College of Medicine, Houston, TX, 77030, USA., Raji IO; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX, 77030, USA.; Center for Drug Discovery, Baylor College of Medicine, Houston, TX, 77030, USA., Guduru SKR; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX, 77030, USA.; Center for Drug Discovery, Baylor College of Medicine, Houston, TX, 77030, USA., Kandel P; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX, 77030, USA.; Center for Drug Discovery, Baylor College of Medicine, Houston, TX, 77030, USA., Nguyen M; Department of Chemistry, Rice University, Houston, TX, 77030, USA., Liu S; Department of Chemistry, Rice University, Houston, TX, 77030, USA., Tran K; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX, 77030, USA., Venugopal NK; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX, 77030, USA., Taylor BC; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, 77030, USA., Holt MV; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, 77030, USA., Young NL; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, 77030, USA., Samuel ELG; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX, 77030, USA.; Center for Drug Discovery, Baylor College of Medicine, Houston, TX, 77030, USA., Jain P; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX, 77030, USA.; Center for Drug Discovery, Baylor College of Medicine, Houston, TX, 77030, USA., Santini C; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX, 77030, USA.; Center for Drug Discovery, Baylor College of Medicine, Houston, TX, 77030, USA.; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, 77030, USA., Sankaran B; Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA., MacKenzie KR; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX, 77030, USA.; Center for Drug Discovery, Baylor College of Medicine, Houston, TX, 77030, USA.; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, 77030, USA., Young DW; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX, 77030, USA. Damian.Young@bcm.edu.; Center for Drug Discovery, Baylor College of Medicine, Houston, TX, 77030, USA. Damian.Young@bcm.edu.; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, 77030, USA. Damian.Young@bcm.edu.; Therapeutic Innovations Center, Baylor College of Medicine, Houston, TX, 77030, USA. Damian.Young@bcm.edu.

Publikováno v: Scientific reports [Sci Rep] 2021 Jan 13; Vol. 11 (1), pp. 1121. Date of Electronic Publication: 2021 Jan 13.

Synthesis and biological evaluation of rapamycin-derived, next generation small molecules.

Autor: Guduru SKR; Center for Drug Discovery , Department of Pharmacology and Chemical Biology , Baylor College of Medicine , One Baylor Plaza , Houston , Texas 77030 , USA . Email: gskreddy.chem@gmail.com ; Email: Shiva.Guduru@bcm.edu ; Tel: +1 713 798 8794.; Department of Pharmacology and Chemical Biology , Baylor College of Medicine , One Baylor Plaza , Houston , Texas 77030 , USA., Arya P; Chemistry and Chemical Biology , Dr. Reddy's Institute of Life Sciences (DRILS) , University of Hyderabad Campus , Hyderabad 500046 , India.

Publikováno v: MedChemComm [Medchemcomm] 2017 Nov 22; Vol. 9 (1), pp. 27-43. Date of Electronic Publication: 2017 Nov 22 (Print Publication: 2018).