Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Gudula Grammer"'
Autor:
Harald Steiner, Elisabeth Kremmer, Regina Fluhrer, David B. Teplow, Edith Winkler, Gudula Grammer, Lucas Martin, Margaret M. Condron, Bärbel Klier, Christian Haass, Akio Fukumori, Martina Haug-Kröper
Publikováno v:
J. Biol. Chem. 283, 30121-30128 (2008)
Fluhrer, R; Fukumori, A; Martin, L; Grammer, G; Haug-Kröper, M; Klier, B; et al.(2008). Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation. Journal of Biological Chemistry, 283(44), 30121-30128. doi: 10.1074/jbc.M806092200. UCLA: Retrieved from: http://www.escholarship.org/uc/item/2ht7q8wh
The Journal of biological chemistry, vol 283, iss 44
Fluhrer, R; Fukumori, A; Martin, L; Grammer, G; Haug-Kröper, M; Klier, B; et al.(2008). Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation. Journal of Biological Chemistry, 283(44), 30121-30128. doi: 10.1074/jbc.M806092200. UCLA: Retrieved from: http://www.escholarship.org/uc/item/2ht7q8wh
The Journal of biological chemistry, vol 283, iss 44
More than 150 familial Alzheimer disease (FAD)-associated missense mutations in presenilins (PS1 and PS2), the catalytic subunit of the γ-secretase complex, cause aberrant amyloid β-peptide (Aβ) production, by increasing the relative production of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::713e4427d4b8e2e74165fb0c8d0fdec8
https://doi.org/10.1074/jbc.m806092200
https://doi.org/10.1074/jbc.m806092200
Autor:
Stefan F. Lichtenthaler, Regina Fluhrer, Matthias Voss, Alessio Colombo, Martina Haug-Kröper, Harald Steiner, Gudula Grammer, Bärbel Klier, Fabian Higel, Christian Haass, Bernd Schröder, Andreas Seidl, Reinhard Obst, Peer-Hendrik Kuhn, Akio Fukumori, Ulrike Künzel
Publikováno v:
The EMBO journal 33(24), 2890-2905 (2014). doi:10.15252/embj.201488375
Protein N-glycosylation is involved in a variety of physiological and pathophysiological processes such as autoimmunity, tumour progression and metastasis. Signal peptide peptidase-like 3 (SPPL3) is an intramembrane-cleaving aspartyl protease of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c191e80c15a9fb9a4d4d089c104136df
https://pubmed.ncbi.nlm.nih.gov/25414474
https://pubmed.ncbi.nlm.nih.gov/25414474
Autor:
Gudula Grammer, Regina Fluhrer, Christian Haass, Axel Imhof, Christof Haffner, Claudia Böhland, Bruno Martoglio, Margaret M. Condron, David B. Teplow, Elena Friedmann, Lars Israel
Publikováno v:
Fluhrer, R; Grammer, G; Israel, L; Condron, MM; Haffner, C; Friedmann, E; et al.(2006). A γ-secretase-like intramembrane cleavage of TNFα by the GxGD aspartyl protease SPPL2b. Nature Cell Biology, 8(8), 894-896. doi: 10.1038/ncb1450. UCLA: Retrieved from: http://www.escholarship.org/uc/item/59c2q1jk
γ-secretase and signal peptide peptidase (SPP) are unusual GxGD aspartyl proteases, which mediate intramembrane proteolysis. In addition to SPP, a family of SPP-like proteins (SPPLs) of unknown function has been identified. We demonstrate that SPPL2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dacb4c3a8bd95c1202410a6606687887
https://doi.org/10.1038/ncb1450
https://doi.org/10.1038/ncb1450
Autor:
Gudula Grammer, Lucas Martin, Brigitte Nuscher, Regina Fluhrer, Bärbel Klier, Christian Haass, Martina Haug-Kröper
Publikováno v:
The journal of biological chemistry 287(7), 5156-5163 (2011). doi:10.1074/jbc.M111.328104
Regulated intramembrane proteolysis is a widely accepted concept describing the processing of various transmembrane proteins via ectodomain shedding followed by an intramembrane cleavage. The resulting cleavage products can be involved in reverse sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbdfbda0abaed1d5d10ecd472863c0f0
https://pubmed.ncbi.nlm.nih.gov/22194595
https://pubmed.ncbi.nlm.nih.gov/22194595
Autor:
Gudula Grammer, Klaus Beyer, Regina Fluhrer, Brigitte Nuscher, Harald Steiner, Frits Kamp, Christian Haass
Publikováno v:
Biological chemistry 392(11), 995–1001 (2011). doi:10.1515/BC.2011.169
Nicastrin is a type I transmembrane glycoprotein, which is part of the high molecular weight γ-secretase complex. γ-Secretase is one of the key players associated with the generation of Alzheimer's disease pathology, since it liberates the neurotox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ac0cdcf577a714ce0905496fca0097
