Výsledky vyhledávání - "Gudrun von Scheven"

Akademický článek

Comparative analysis of chlorambucil-induced DNA lesion formation and repair in a spectrum of different human cell systems

Autor: Sarah Ceylan Krassnig, Marina Mäser, Nicola Anna Probst, Jens Werner, Charlotte Schlett, Nina Schumann, Gudrun von Scheven, Aswin Mangerich, Alexander Bürkle

Publikováno v: Toxicology Reports, Vol 10, Iss , Pp 171-189 (2023)

Chlorambucil (CLB) belongs to the class of nitrogen mustards (NMs), which are highly reactive bifunctional alkylating agents and were the first chemotherapeutic agents developed. They form DNA interstrand crosslinks (ICLs), which cause a blockage of

Externí odkaz: https://doaj.org/article/4cf2e1ac875444ff9edb92dd65be03db

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Akademický článek

DNA Damage and Radiosensitivity in Blood Cells from Subjects Undergoing 45 Days of Isolation and Confinement: An Explorative Study

Autor: Alan H. Feiveson, Stephanie S. Krieger, Gudrun von Scheven, Brian E. Crucian, Alexander Bürkle, Alexander C. Stahn, Honglu Wu, María Moreno-Villanueva

Publikováno v: Current Issues in Molecular Biology, Vol 44, Iss 2, Pp 654-669 (2022)

The effect of confined and isolated experience on astronauts’ health is an important factor to consider for future space exploration missions. The more confined and isolated humans are, the more likely they are to develop negative behavioral or cog

Externí odkaz: https://doaj.org/article/39df9d3d195a4f2193383506f7d27204

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Akademický článek

Synergistic Effects of Weightlessness, Isoproterenol, and Radiation on DNA Damage Response and Cytokine Production in Immune Cells

Autor: Maria Moreno-Villanueva, Alan H. Feiveson, Stephanie Krieger, AnneMarie Kay Brinda, Gudrun von Scheven, Alexander Bürkle, Brian Crucian, Honglu Wu

Publikováno v: International Journal of Molecular Sciences, Vol 19, Iss 11, p 3689 (2018)

The implementation of rotating-wall vessels (RWVs) for studying the effect of lack of gravity has attracted attention, especially in the fields of stem cells, tissue regeneration, and cancer research. Immune cells incubated in RWVs exhibit several fe

Externí odkaz: https://doaj.org/article/e0076d77dfed46efadaba53b9be360d1

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The Radioprotective Effect of Procaine and Procaine-Derived Product Gerovital H3 in Lymphocytes from Young and Aged Individuals

Autor: Gudrun von Scheven, Yves Artur, Claudia Borsa, Maria Moreno-Villanueva, Philippe Faure, Daniela Gradinaru, Lucie Oziol, Cristina Ionescu, Anca Ungurianu, Alexander Bürkle, Denisa Margina

Publikováno v: Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Hindawi, 2020, 2020, pp.3580934. ⟨10.1155/2020/3580934⟩
Oxidative Medicine and Cellular Longevity, Vol 2020 (2020)

International audience; Ionizing radiation induces genomic instability in living organisms, and several studies reported an ageing-dependent radiosensitivity. Chemical compounds, such as scavengers, radioprotectors, and modifiers, contribute to reduc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d18c0d00b44c81a48060e5dd0622cd67
https://doi.org/10.1155/2020/3580934

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Impaired PARP activity in response to the β-adrenergic receptor agonist isoproterenol

Autor: Tamara Schuhmacher, Gudrun von Scheven, Alexander Bürkle, Mara Thomas, Judy Salzwedel, Maria Moreno-Villanueva, Philipp Palombo, Viktoriia Bazylianska, Nadine Schäfer

Publikováno v: Toxicology in Vitro. 50:29-39

Psychological stress has been associated with DNA damage, thus increasing the risk of numerous diseases including cancer. Here, we investigate the effect of acute and chronic stress on poly(ADP-ribose) polymerase-1 (PARP-1), a sensor of DNA damage an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::658aa2e5aedd9004322fa8cfc06c0582
https://doi.org/10.1016/j.tiv.2018.02.001

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The degree of radiation-induced DNA strand breaks is altered by acute sleep deprivation and psychological stress and is associated with cognitive performance in humans

Autor: Honglu Wu, Alexander Bürkle, Gudrun von Scheven, Namni Goel, Maria Moreno-Villanueva, Alan H. Feiveson

Study ObjectivesSleep deprivation is associated with impaired immune responses, cancer, and morbidity and mortality, and can degrade cognitive performance, although individual differences exist in such responses. Sleep deprivation induces DNA strand

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac66cfa92f07019bb3d8e02721ec26fb

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RNA polymerase III-specific general transcription factor IIIC contains a heterodimer resembling TFIIF Rap30/Rap74

Autor: Christoph W. Müller, Florence Baudin, Nicholas M.I. Taylor, Gudrun von Scheven

Publikováno v: 'Nucleic Acids Research ', vol: 41, pages: 9183-9196 (2013)
Nucleic Acids Research

Transcription of tRNA-encoding genes by RNA polymerase (Pol) III requires the six-subunit general transcription factor IIIC that uses subcomplexes τA and τB to recognize two gene-internal promoter elements named A- and B-box. The Schizosaccharomyce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8c0c5efe0dbfdcf93ca2d820bf3babf
https://doi.org/10.1093/nar/gkt664

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Structural and Functional Characterization of a Phosphatase Domain within Yeast General Transcription Factor IIIC

Autor: Christoph W. Müller, Carlos Fernández-Tornero, Anne-Claude Gavin, Peter Kolb, Sebastian Glatt, Vladimir Rybin, Marco L. Hennrich, Helga Grötsch, Gudrun von Scheven, Nicholas M.I. Taylor

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Journal of Biological Chemistry, Vol. 288, No 21 (2013) pp. 15110-15120

12 p.-5 fig.-2 tab.
Saccharomyces cerevisiae τ55, a subunit of the RNA polymerase III-specific general transcription factor TFIIIC, comprises an N-terminal histidine phosphatase domain (τ55-HPD) whose catalytic activity and cellular function i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ddfc89eefa5df83bc5e6aa9f0864194
https://doi.org/10.1074/jbc.m112.427856

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Neural tube derived signals and Fgf8 act antagonistically to specify eye versus mandibular arch muscles

Autor: Gudrun von Scheven, Susanne Dietrich, Roy C. Mootoosamy, Lúcia Elvira Alvares

Publikováno v: Development. 133:2731-2745

Recent knockout experiments in the mouse generated amazing craniofacial skeletal muscle phenotypes. Yet none of the genes could be placed into a molecular network, because the programme to control the development of muscles in the head is not known.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b21c5b8d24403b452335b1162ee6c81
https://doi.org/10.1242/dev.02426

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Extrinsic versus intrinsic cues in avian paraxial mesoderm patterning and differentiation

Autor: Ingo Bothe, Susanne Dietrich, Farrah Leigh Winterbottom, Gudrun von Scheven, Mohi Ahmed

Publikováno v: Developmental dynamics : an official publication of the American Association of Anatomists. 236(9)

Somitic and head mesoderm contribute to cartilage and bone and deliver the entire skeletal musculature. Studies on avian somite patterning and cell differentiation led to the view that these processes depend solely on cues from surrounding tissues. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8043f0ead99407a68375dda8b19ee05
https://pubmed.ncbi.nlm.nih.gov/17654605

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