Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Gudrun Volkert"'
Autor:
Ines Marek, Robert Becker, Fabian B. Fahlbusch, Carlos Menendez-Castro, Wolfgang Rascher, Christoph Daniel, Gudrun Volkert, Andrea Hartner
Publikováno v:
Cellular Physiology and Biochemistry, Vol 45, Iss 6, Pp 2161-2173 (2018)
Background/Aims: Healing of mesangioproliferative glomerulonephritis involves degradation of excess extracellular matrix, resolution of hypercellularity by apoptosis and phagocytosis of apoptotic cells. Integrin receptors participate in the regulatio
Externí odkaz:
https://doaj.org/article/6f2d9f40ab014d76866c9d49df9e15fd
Autor:
Ines Marek, Maurizio Canu, Nada Cordasic, Manfred Rauh, Gudrun Volkert, Fabian B. Fahlbusch, Wolfgang Rascher, Karl F. Hilgers, Andrea Hartner, Carlos Menendez-Castro
Publikováno v:
Biology of Sex Differences, Vol 8, Iss 1, Pp 1-13 (2017)
Abstract Background Apoe-deficient (Apoe −/−) mice develop progressive atherosclerotic lesions with age but no severe renal pathology in the absence of additional challenges. We recently described accelerated atherosclerosis as well as marked ren
Externí odkaz:
https://doaj.org/article/6939bdb294a848eba90051ddeeb509db
Autor:
Ines Marek, Till Lichtneger, Nada Cordasic, Karl F Hilgers, Gudrun Volkert, Fabian Fahlbusch, Wolfgang Rascher, Andrea Hartner, Carlos Menendez-Castro
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150471 (2016)
The α8 integrin (Itga8) chain contributes to the regulation of cell proliferation and apoptosis in renal glomerular cells. In unilateral ureteral obstruction Itga8 is de novo expressed in the tubulointerstitium and a deficiency of Itga8 results in m
Externí odkaz:
https://doaj.org/article/0075489ee50c4d79a7b62463f12082f4
Autor:
Andrea Hartner, Carlos Menendez-Castro, Nada Cordasic, Ines Marek, Gudrun Volkert, Bernd Klanke, Wolfgang Rascher, Karl F Hilgers
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48362 (2012)
In the normal kidney, the α8 integrin chain is expressed only on mesangial cells and vascular smooth muscle cells. α8 integrin ligates several matrix molecules including fibronectin, osteopontin and fibrillin-1. Recently, we detected de novo expres
Externí odkaz:
https://doaj.org/article/70fc8bf13efa4e469243cfd6bc534dfc
Autor:
Fabian B. Fahlbusch, Hanna Huebner, Carlos Menendez-Castro, Wolfgang Rascher, Stephanie C. Noegel, Ines Marek, Sebastian Herdl, Gudrun Volkert, Andrea Hartner, Matthias Ruebner
Publikováno v:
Reproductive Sciences. 24:1426-1437
Objective: Integrins exert regulatory functions in placentogenesis. Null mutation of certain integrin α subunits leads to placental defects with subsequent fetal growth restriction or embryonic lethality in mice. So far, the placental role of α8 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79d77de4df5b15c833c49ac19a8ad84a
https://doi.org/10.1177/1933719116689597
https://doi.org/10.1177/1933719116689597
Autor:
Daniel Neureiter, Sebastian Stintzing, Ines Marek, Kerstin Amann, Nada Cordasic, Angelika Jahn, Carlos Menendez-Castro, Karl F. Hilgers, Wolfgang Rascher, Andrea Hartner, Gudrun Volkert
Publikováno v:
The Journal of Pathology. 236:5-16
Integrins play an important role in vascular biology. The α8 integrin chain attenuates smooth muscle cell migration but its functional role in the development of atherosclerosis is unclear. Therefore, we studied the contribution of α8 integrin to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cfa0dd9b9d122a37db77c99b41ad228
https://doi.org/10.1002/path.4501
https://doi.org/10.1002/path.4501
Autor:
Wolfgang Rascher, Christina Dinkel, Karl F. Hilgers, Andrea Hartner, Angelika Jahn, Gudrun Volkert, Christina Zürn, Fabian B. Fahlbusch, Ines Marek
Publikováno v:
Cell Communication & Adhesion. 21:89-98
In the kidney, the α8 integrin chain (itga8) is expressed in mesenchymal cells and is upregulated in fibrotic disease. We hypothesized that itga8 mediates a profibrotic phenotype of renal cells by promoting extracellular matrix and cytokine expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::323338fbba074c430a4b2f370c0cabe7
https://doi.org/10.3109/15419061.2013.876012
https://doi.org/10.3109/15419061.2013.876012
Autor:
C. Zuern, Andrea Hartner, Carlos Menendez-Castro, David L. Wachter, Falk Thiel, Wolfgang Rascher, Matthias Ruebner, Hanna Huebner, Fabian B. Fahlbusch, Martin Koch, Gudrun Volkert
Publikováno v:
Placenta. 34:1027-1035
Introduction Gastrokine-1 (GKN1) is a secreted auto-/paracrine protein, described to be expressed in the gastric mucosa. In gastric cancers GKN1 expression is commonly down-regulated. While current research focusses on the exploration of tumor-suppre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d66f94f0c5efd9f7dd09af2a79cf4f5c
https://doi.org/10.1016/j.placenta.2013.08.005
https://doi.org/10.1016/j.placenta.2013.08.005
Autor:
Nada Cordasic, Miroslava Kupraszewicz-Hutzler, Gudrun Volkert, Carlos Menendez-Castro, Karl F. Hilgers, Wolfgang Rascher, Julie M. Yabu, Andrea Hartner
Publikováno v:
American Journal of Physiology-Renal Physiology. 299:F1151-F1157
Development of diabetic nephropathy is accompanied by changes in integrin-mediated cell-matrix interactions. The α8-integrin chain is specifically expressed in mesangial cells of the glomerulus. During experimental hypertension, α8-integrin plays a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95a4c0dc5e473762076e9b0c6ab4181d
https://doi.org/10.1152/ajprenal.00058.2010
https://doi.org/10.1152/ajprenal.00058.2010
Autor:
Stephanie C. Noegel, Regine Schneider-Stock, Sven Kehl, Hannah Bartunik, Ines Marek, Andrea Hartner, Gudrun Volkert, Wolfgang Rascher, Fabian B. Fahlbusch, Carlos Menendez-Castro, David L. Wachter, Ilona Winterfeld, Hanna Huebner, Matthias Ruebner, Matthias W. Beckmann
Publikováno v:
Histochemistry and cell biology. 144(3)
Gastrokines (GKNs) were originally described as stomach-specific tumor suppressor genes. Recently, we identified GKN1 in extravillous trophoblasts (EVT) of human placenta. GKN1 treatment reduced the migration of the trophoblast cell line JEG-3. GKN2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6864f4250fb476be5ab13291ce894022
https://pubmed.ncbi.nlm.nih.gov/26070363
https://pubmed.ncbi.nlm.nih.gov/26070363