Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Gudrun E Koehl"'
Autor:
Christian Schmidl, Wolfgang Herr, Nathalie Babl, Sonja-Maria Decking, Florian Voll, Michael Althammer, Ada Sala-Hojman, Roberta Ferretti, Clarissa Korf, Lisa Schmidleithner, Benedikt Nerb, Carina Matos, Gudrun E Koehl, Peter Siska, Christina Bruss, Fabian Kellermeier, Katja Dettmer, Peter J Oefner, Marvin Wichland, Ines Ugele, Christopher Bohr, Shivapriya Ramaswamy, Timo Heinrich, Christian Herhaus, Marina Kreutz, Kathrin Renner
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 10 (2023)
Background & Aims Intratumoral lactate accumulation and acidosis impair T-cell function and antitumor immunity. Interestingly, expression of the lactate transporter monocarboxylate transporter (MCT) 4, but not MCT1, turned out to be prognostic for th
Externí odkaz:
https://doaj.org/article/c03d167b710e4bcd97adb742f3e84064
Autor:
Christiane Broichhausen, Paloma Riquelme, Norbert Ahrens, Anja K Wege, Gudrun E Koehl, Hans J Schlitt, Bernhard Banas, Fred Fändrich, Edward K Geissler, James A Hutchinson
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 1, Iss C (2014)
A new cell-based medicinal product containing human regulatory macrophages, known as Mreg_UKR, has been developed and conforms to expectations of a therapeutic drug. Here, Mreg_UKR was subjected to pharmacokinetic, safety pharmacology, and toxicologi
Externí odkaz:
https://doaj.org/article/4d6ed0972d8c47da818a90fe9ed5644f
Autor:
Frank R. De Gruijl, Edward K. Geissler, Rein Willemze, Jan N. Bouwes Bavinck, Cornelis P. Tensen, Abdoel El Ghalbzouri, Andreas Gaumann, Marjolein G.E. Van Olderen, Heggert G. Rebel, Gudrun E Koehl, Carolien A Bodmann, Pieter Voskamp
PDF file - 67K, Supplementary table 1; Primer sequences. Supplementary figure 1; Effects of immunosuppressive drugs on epidermal proliferation in HSEs (n=3-4) as % of Ki-67 positive (supra-)basal cells. Supplementary figure 2: Mice on Aza diet (A) sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a5e39ede1729a72d0a23e474160257
https://doi.org/10.1158/1940-6207.22524020.v1
https://doi.org/10.1158/1940-6207.22524020.v1
Autor:
Edward K. Geissler, Peter J. Oefner, Jerzy Adamski, Sven A. Lang, Andreas Gaumann, Christian H. Wetzel, Christine Ziegler, Karl Kunzelmann, Hans J. Schlitt, Vadivel Ganapathy, Christian J. Wachsmuth, Elke Eggenhofer, Gudrun E. Koehl, Alexander Cecil, Moritz Schladt, Margareta Lantow, Gregor M. Madej, Wolfgang Jagla, Vladimir M. Milenkovic, Cornelia Prehn, Katharina Schmidt, Petra Rümmele, Katja Dettmer, Maria E. Mycielska
Krebs cycle activity in the presence of extracellular citrate and absolute citrate levels.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33562ad332dd0da3e0d23cbf15bbe656
https://doi.org/10.1158/0008-5472.22419494.v1
https://doi.org/10.1158/0008-5472.22419494.v1
Autor:
Edward K. Geissler, Peter J. Oefner, Jerzy Adamski, Sven A. Lang, Andreas Gaumann, Christian H. Wetzel, Christine Ziegler, Karl Kunzelmann, Hans J. Schlitt, Vadivel Ganapathy, Christian J. Wachsmuth, Elke Eggenhofer, Gudrun E. Koehl, Alexander Cecil, Moritz Schladt, Margareta Lantow, Gregor M. Madej, Wolfgang Jagla, Vladimir M. Milenkovic, Cornelia Prehn, Katharina Schmidt, Petra Rümmele, Katja Dettmer, Maria E. Mycielska
List of metabolites measured with the AbsoluteIDQ® p180 Kit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::408231ff14334a296c84657258cda4df
https://doi.org/10.1158/0008-5472.22419476
https://doi.org/10.1158/0008-5472.22419476
Autor:
Edward K. Geissler, Peter J. Oefner, Jerzy Adamski, Sven A. Lang, Andreas Gaumann, Christian H. Wetzel, Christine Ziegler, Karl Kunzelmann, Hans J. Schlitt, Vadivel Ganapathy, Christian J. Wachsmuth, Elke Eggenhofer, Gudrun E. Koehl, Alexander Cecil, Moritz Schladt, Margareta Lantow, Gregor M. Madej, Wolfgang Jagla, Vladimir M. Milenkovic, Cornelia Prehn, Katharina Schmidt, Petra Rümmele, Katja Dettmer, Maria E. Mycielska
Intracellular Ca2+ in the presence of extracellular citrate.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a535b0300734e156283b03f831ae8bd8
https://doi.org/10.1158/0008-5472.22419497.v1
https://doi.org/10.1158/0008-5472.22419497.v1
Autor:
Edward K. Geissler, Peter J. Oefner, Jerzy Adamski, Sven A. Lang, Andreas Gaumann, Christian H. Wetzel, Christine Ziegler, Karl Kunzelmann, Hans J. Schlitt, Vadivel Ganapathy, Christian J. Wachsmuth, Elke Eggenhofer, Gudrun E. Koehl, Alexander Cecil, Moritz Schladt, Margareta Lantow, Gregor M. Madej, Wolfgang Jagla, Vladimir M. Milenkovic, Cornelia Prehn, Katharina Schmidt, Petra Rümmele, Katja Dettmer, Maria E. Mycielska
Glycolysis and fatty acid synthesis are highly active in cancer cells through cytosolic citrate metabolism, with intracellular citrate primarily derived from either glucose or glutamine via the tricarboxylic acid cycle. We show here that extracellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55b93db68abae791c8ca94d3e47f4aed
https://doi.org/10.1158/0008-5472.c.6510392.v1
https://doi.org/10.1158/0008-5472.c.6510392.v1
Autor:
Manon Vullings, Fabian M. P. Kaiser, Edward K. Geissler, Stephanie Alexander, Stephan Kissler, Cornelia Veelken, Markus Hirschberg, Michael Flentje, Uta Flucke, Anna Haeger, Gudrun E. Koehl, Robert M. Hoffman, Peter Friedl
Publikováno v:
Journal of Experimental Medicine, 217, 1
The Journal of Experimental Medicine
Journal of Experimental Medicine, 217
The Journal of Experimental Medicine
Journal of Experimental Medicine, 217
This work identifies an integrin-dependent tissue niche that supports both collective invasion and radiation resistance and can be eradicated by joint targeting of β1 and αV integrins, but neither alone. The additive effect of multiple-integrin int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dee5f4235bd8e779a9abdc1bd8e62d75
https://hdl.handle.net/2066/219833
https://hdl.handle.net/2066/219833
Autor:
Wolfgang Mueller-Klieser, Evelyn Ullrich, E. K. Geissler, Andreas Villunger, Almut Brand, Sigrid Karrer, Kathrin Renner, André Steven, Peter J. Oefner, Stefan Walenta, Elisabeth Kohl, Annette Thiel, Christian U. Blank, Gudrun E. Koehl, Jacques Pouysségur, Sebastian Haferkamp, Maximilian Schmid, Marina Kreutz, Carina Matos, Stefan Fichtner-Feigl, Katja Dettmer, Petra Hoffmann, Ulrike Schleicher, Sebastian Klobuch, Barbara Seliger, Katrin Singer, Michael Kastenberger, Christian Bogdan, Matthias Mack, Mark Berneburg, K. Peter, Stephan Schreml, Uwe Ritter, Wolfgang Herr, Marlene Kolitzus, Andreas Mackensen, Christina Bruss, Rebecca Kesselring, Gabriele Schoenhammer
Publikováno v:
Cell Metabolism. 24:657-671
Elevated lactate dehydrogenase A (LDHA) expression is associated with poor outcome in tumor patients. Here we show that LDHA-associated lactic acid accumulation in melanomas inhibits tumor surveillance by T and NK cells. In immunocompetent C57BL/6 mi
Autor:
Gudrun E. Koehl, Sven A. Lang, J. M. Campistol, M. Sabet-Baktach, Jordi Rovira, Alexander Kroemer, Philipp Renner, Hans Juergen Schlitt, Elke Eggenhofer, Margareta Lantow, E. K. Geissler
Publikováno v:
American Journal of Transplantation. 16:1139-1147
Transplant recipients face an increased risk of cancer compared with the healthy population. Although several studies have examined the direct effects of immunosuppressive drugs on cancer cells, little is known about the interactions between pharmaco