Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Gudrun Antoons"'
Autor:
Ge Jin, Martin Manninger, Gabriel Adelsmayr, Michael Schwarzl, Alessio Alogna, Patrick Schönleitner, David Zweiker, Florian Blaschke, Mohammad Sherif, Snjezana Radulovic, Paulina Wakula, Sylvia Schauer, Gerald Höfler, Ursula Reiter, Gert Reiter, Heiner Post, Daniel Scherr, Karoly Acsai, Gudrun Antoons, Burkert Pieske, Frank R. Heinzel
Publikováno v:
ESC Heart Failure, Vol 8, Iss 1, Pp 151-161 (2021)
Abstract Aims Atrial contractile dysfunction contributes to worse prognosis in hypertensive heart disease (HHD), but the role of cardiomyocyte dysfunction in atrial remodelling in HHD is not well understood. We investigated and compared cellular mech
Externí odkaz:
https://doaj.org/article/e3cd5ed0ec9d4e898a46ba808604b0f8
Autor:
Ilvy M. E. Geraets, Will A. Coumans, Agnieszka Strzelecka, Patrick Schönleitner, Gudrun Antoons, Francesco Schianchi, Myrthe M. A. Willemars, Dimitrios Kapsokalyvas, Jan F. C. Glatz, Joost J. F. P. Luiken, Miranda Nabben
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7, p 3620 (2021)
(1) Background: The exact mechanism(s) underlying pathological changes in a heart in transition to hypertrophy and failure are not yet fully understood. However, alterations in cardiac energy metabolism seem to be an important contributor. We charact
Externí odkaz:
https://doaj.org/article/dc228c9f9206495a8e1bb0573d0e016c
Autor:
Shujin Wang, Li-Yen Wong, Dietbert Neumann, Yilin Liu, Aomin Sun, Gudrun Antoons, Agnieszka Strzelecka, Jan F.C. Glatz, Miranda Nabben, Joost J.F.P. Luiken
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 4, p 1520 (2020)
The diabetic heart is characterized by a shift in substrate utilization from glucose to lipids, which may ultimately lead to contractile dysfunction. This substrate shift is facilitated by increased translocation of lipid transporter CD36 (SR-B2) fro
Externí odkaz:
https://doaj.org/article/058274f6313e4bea9e05c70e0de16bf4
Autor:
Daniel M. Johnson, Gudrun Antoons
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Heart failure (HF) is associated with elevated sympathetic tone and mechanical load. Both systems activate signaling transduction pathways that increase cardiac output, but eventually become part of the disease process itself leading to further worse
Externí odkaz:
https://doaj.org/article/db6e20e6329b4dc0b569740d0bba0a2d
Autor:
Henry Sutanto, Bart van Sloun, Patrick Schönleitner, Marc A. M. J. van Zandvoort, Gudrun Antoons, Jordi Heijman
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Spontaneous Ca2+-release events (SCaEs) from the sarcoplasmic reticulum play crucial roles in the initiation of cardiac arrhythmias by promoting triggered activity. However, the subcellular determinants of these SCaEs remain incompletely understood.
Externí odkaz:
https://doaj.org/article/b7bb82bf52f9458fb7ccfda812d4db1f
Autor:
Patricia Garcia-Canadilla, Jose F Rodriguez, Maria J Palazzi, Anna Gonzalez-Tendero, Patrick Schönleitner, Vedrana Balicevic, Sven Loncaric, Joost J F P Luiken, Mario Ceresa, Oscar Camara, Gudrun Antoons, Fatima Crispi, Eduard Gratacos, Bart Bijnens
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0182915 (2017)
Experimental studies on isolated cardiomyocytes from different animal species and human hearts have demonstrated that there are regional differences in the Ca2+ release, Ca2+ decay and sarcomere deformation. Local deformation heterogeneities can occu
Externí odkaz:
https://doaj.org/article/c1b320ee731b44e38332c55f99974972
Autor:
Jan F. C. Glatz, Ilvy M. E. Geraets, Dimitrios Kapsokalyvas, Gudrun Antoons, Agnieszka Strzelecka, Myrthe M. A. Willemars, Will A. Coumans, Miranda Nabben, Francesco Schianchi, Patrick Schönleitner, Joost J. F. P. Luiken
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 7
International Journal of Molecular Sciences, Vol 22, Iss 3620, p 3620 (2021)
International journal of molecular sciences, 22(7):3620. Multidisciplinary Digital Publishing Institute (MDPI)
Volume 22
Issue 7
International Journal of Molecular Sciences, Vol 22, Iss 3620, p 3620 (2021)
International journal of molecular sciences, 22(7):3620. Multidisciplinary Digital Publishing Institute (MDPI)
(1) Background: The exact mechanism(s) underlying pathological changes in a heart in transition to hypertrophy and failure are not yet fully understood. However, alterations in cardiac energy metabolism seem to be an important contributor. We charact
Autor:
Gudrun Antoons, Norbert Nagy, Károly Acsai, Piero Pollesello, Zsófia Kohajda, Jouko Levijoki, Kinga Oravecz, Zoltán Márton, Norbert Jost, Leila Mirzaei, Tuula Koskelainen, Andrea Gruber, Péter P. Nánási, András Varró, András Tóth, Leena Otsomaa, Julius Gy. Papp, Anita Kormos
Publikováno v:
European Journal of Pharmacology, 818, 278-286. Elsevier Science
Na+/Ca2+ exchanger (NCX) is the main Ca2+ transporter in cardiac myocytes. Its inhibition could be expected to exert positive inotropic action by accumulation of cytosolic Ca2+ ([Ca2+](i)). However, we have observed only a marginal positive inotropic
Publikováno v:
Progress in Biophysics and Molecular Biology. 130:288-301
In cardiac myocytes, calcium (Ca2+) signalling is tightly controlled in dedicated microdomains. At the dyad, i.e. the narrow cleft between t-tubules and junctional sarcoplasmic reticulum (SR), many signalling pathways combine to control Ca2+-induced
Autor:
Laura K.M. Steinbusch, Joost J. F. P. Luiken, Dimitris Kapsokalyvas, Gudrun Antoons, Dipanjan Chanda, Jan F. C. Glatz, Amber Geomini, Yilin Liu, Peter J. Simons, Miranda Nabben, Patrick Schönleitner, Dietbert Neumann, Marc A. M. J. van Zandvoort, Will A. Coumans
Publikováno v:
Diabetes, 66(6), 1521-1534. American Diabetes Association
Dietary fat overconsumption leads to myocardial lipid accumulation through mechanisms that are incompletely resolved. Previously, we identified increased translocation of the fatty acid transporter CD36 from its endosomal storage compartment to the s