Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Gudrun, Rutsdottir"'
Autor:
Saedis Saevarsdottir, Kristbjörg Bjarnadottir, Thorsteinn Markusson, Jonas Berglund, Thorunn A. Olafsdottir, Gisli H. Halldorsson, Gudrun Rutsdottir, Kristbjorg Gunnarsdottir, Asgeir Orn Arnthorsson, Sigrun H. Lund, Lilja Stefansdottir, Julius Gudmundsson, Ari J. Johannesson, Arni Sturluson, Asmundur Oddsson, Bjarni Halldorsson, Björn R. Ludviksson, Egil Ferkingstad, Erna V. Ivarsdottir, Gardar Sveinbjornsson, Gerdur Grondal, Gisli Masson, Grimur Hjorleifsson Eldjarn, Gudmundur A. Thorisson, Katla Kristjansdottir, Kirk U. Knowlton, Kristjan H. S. Moore, Sigurjon A. Gudjonsson, Solvi Rognvaldsson, Stacey Knight, Lincoln D. Nadauld, Hilma Holm, Olafur T. Magnusson, Patrick Sulem, Daniel F. Gudbjartsson, Thorunn Rafnar, Gudmar Thorleifsson, Pall Melsted, Gudmundur L. Norddahl, Ingileif Jonsdottir, Kari Stefansson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Autoimmune thyroid disease (AITD) is a common autoimmune disease. In a GWAS meta-analysis of 110,945 cases and 1,084,290 controls, 290 sequence variants at 225 loci are associated with AITD. Of these variants, 115 are previously unreported.
Externí odkaz:
https://doaj.org/article/6749a49ac9b842aa843a6662930b9531
Autor:
Saedis, Saevarsdottir, Lilja, Stefansdottir, Patrick, Sulem, Gudmar, Thorleifsson, Egil, Ferkingstad, Gudrun, Rutsdottir, Bente, Glintborg, Helga, Westerlind, Gerdur, Grondal, Isabella C, Loft, Signe Bek, Sorensen, Benedicte A, Lie, Mikael, Brink, Lisbeth, Ärlestig, Asgeir Orn, Arnthorsson, Eva, Baecklund, Karina, Banasik, Steffen, Bank, Lena I, Bjorkman, Torkell, Ellingsen, Christian, Erikstrup, Oleksandr, Frei, Inger, Gjertsson, Daniel F, Gudbjartsson, Sigurjon A, Gudjonsson, Gisli H, Halldorsson, Oliver, Hendricks, Jan, Hillert, Estrid, Hogdall, Søren, Jacobsen, Dorte Vendelbo, Jensen, Helgi, Jonsson, Alf, Kastbom, Ingrid, Kockum, Salome, Kristensen, Helga, Kristjansdottir, Margit H, Larsen, Asta, Linauskas, Ellen-Margrethe, Hauge, Anne G, Loft, Bjorn R, Ludviksson, Sigrun H, Lund, Thorsteinn, Markusson, Gisli, Masson, Pall, Melsted, Kristjan H S, Moore, Heidi, Munk, Kaspar R, Nielsen, Gudmundur L, Norddahl, Asmundur, Oddsson, Thorunn A, Olafsdottir, Pall I, Olason, Tomas, Olsson, Sisse Rye, Ostrowski, Kim, Hørslev-Petersen, Solvi, Rognvaldsson, Helga, Sanner, Gilad N, Silberberg, Hreinn, Stefansson, Erik, Sørensen, Inge J, Sørensen, Carl, Turesson, Thomas, Bergman, Lars, Alfredsson, Tore K, Kvien, Søren, Brunak, Kristján, Steinsson, Vibeke, Andersen, Ole A, Andreassen, Solbritt, Rantapää-Dahlqvist, Merete Lund, Hetland, Lars, Klareskog, Johan, Askling, Leonid, Padyukov, Ole Bv, Pedersen, Unnur, Thorsteinsdottir, Ingileif, Jonsdottir, Kari, Stefansson
Publikováno v:
Saevarsdottir, S, Stefansdottir, L, Sulem, P, Thorleifsson, G, Ferkingstad, E, Rutsdottir, G, Glintborg, B, Westerlind, H, Grondal, G, Loft, I C, Sorensen, S B, Lie, B A, Brink, M, Ärlestig, L, Arnthorsson, A O, Baecklund, E, Banasik, K, Bank, S, Bjorkman, L I, Ellingsen, T, Erikstrup, C, Frei, O, Gjertsson, I, Gudbjartsson, D F, Gudjonsson, S A, Halldorsson, G H, Hendricks, O, Hillert, J, Hogdall, E, Jacobsen, S, Jensen, D V, Jonsson, H, Kastbom, A, Kockum, I, Kristensen, S, Kristjansdottir, H, Larsen, M H, Linauskas, A, Hauge, E-M, Loft, A G, Ludviksson, B R, Lund, S H, Ostrowski, S R, Sørensen, E, Sørensen, I J, Brunak, S, Andersen, V, Hetland, M L, Askling, J, Pedersen, O B & Members of the DBDS Genomic Consortium 2022, ' Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset ', Annals of the Rheumatic Diseases, vol. 81, no. 8, pp. 1085-1095 . https://doi.org/10.1136/annrheumdis-2021-221754
Saevarsdottir, S, Stefansdottir, L, Sulem, P, Thorleifsson, G, Ferkingstad, E, Rutsdottir, G, Glintborg, B, Westerlind, H, Grondal, G, Loft, I C, Sorensen, S B, Lie, B A, Brink, M, Arlestig, L, Arnthorsson, A O, Baecklund, E, Banasik, K, Bank, S, Bjorkman, L I, Ellingsen, T, Erikstrup, C, Frei, O, Gjertsson, I, Gudbjartsson, D F, Gudjonsson, S A, Halldorsson, G H, Hendricks, O, Hillert, J, Hogdall, E, Jacobsen, S, Jensen, D V, Jonsson, H, Kastbom, A, Kockum, I, Kristensen, S, Kristjansdottir, H, Larsen, M H, Linauskas, A, Hauge, E M, Loft, A G, Ludviksson, B R, Lund, S H, Markusson, T, Masson, G, Melsted, P, Moore, K H S, Munk, H, Nielsen, K R, Norddahl, G L, Oddsson, A, DBDS Genomic Consortium, The Danish RA Genetics Working Group & The Swedish Rheumatology Quality Register Biobank Study Group (SRQb) 2022, ' Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset ', Annals of the Rheumatic Diseases, vol. 81, no. 8, pp. 1085-1095 . https://doi.org/10.1136/annrheumdis-2021-221754
Annals of the Rheumatic Diseases
Saevarsdottir, S, Stefansdottir, L, Sulem, P, Thorleifsson, G, Ferkingstad, E, Rutsdottir, G, Glintborg, B, Westerlind, H, Grondal, G, Loft, I C, Sorensen, S B, Lie, B A, Brink, M, Ärlestig, L, Arnthorsson, A O, Baecklund, E, Banasik, K, Bank, S, Bjorkman, L I, Ellingsen, T, Erikstrup, C, Frei, O, Gjertsson, I, Gudbjartsson, D F, Gudjonsson, S A, Halldorsson, G H, Hendricks, O, Hillert, J, Hogdall, E, Jacobsen, S, Jensen, D V, Jonsson, H, Kastbom, A, Kockum, I, Kristensen, S, Kristjansdottir, H, Larsen, M H, Linauskas, A, Hauge, E-M, Loft, A G, Ludviksson, B R, Lund, S H, Markusson, T, Masson, G, Melsted, P, Moore, K H S, Munk, H, Nielsen, K R, Norddahl, G L, Oddsson, A, Olafsdottir, T A, Olason, P I, Olsson, T, Ostrowski, S R, Hørslev-Petersen, K, Rognvaldsson, S, Sanner, H, Silberberg, G N, Stefansson, H, Sørensen, E, Sørensen, I J, Turesson, C, Bergman, T, Alfredsson, L, Kvien, T K, Brunak, S, Steinsson, K, Andersen, V, Andreassen, O A, Rantapää-Dahlqvist, S, Hetland, M L, Klareskog, L, Askling, J, Padyukov, L, Pedersen, O B, Thorsteinsdottir, U, Jonsdottir, I, Stefansson, K, Members of the DBDS Genomic Consortium & Nyegaard, M 2022, ' Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset ', Annals of the Rheumatic Diseases, vol. 81, no. 8, 221754, pp. 1085-1095 . https://doi.org/10.1136/annrheumdis-2021-221754
Saevarsdottir, S, Stefansdottir, L, Sulem, P, Thorleifsson, G, Ferkingstad, E, Rutsdottir, G, Glintborg, B, Westerlind, H, Grondal, G, Loft, I C, Sorensen, S B, Lie, B A, Brink, M, Arlestig, L, Arnthorsson, A O, Baecklund, E, Banasik, K, Bank, S, Bjorkman, L I, Ellingsen, T, Erikstrup, C, Frei, O, Gjertsson, I, Gudbjartsson, D F, Gudjonsson, S A, Halldorsson, G H, Hendricks, O, Hillert, J, Hogdall, E, Jacobsen, S, Jensen, D V, Jonsson, H, Kastbom, A, Kockum, I, Kristensen, S, Kristjansdottir, H, Larsen, M H, Linauskas, A, Hauge, E M, Loft, A G, Ludviksson, B R, Lund, S H, Markusson, T, Masson, G, Melsted, P, Moore, K H S, Munk, H, Nielsen, K R, Norddahl, G L, Oddsson, A, DBDS Genomic Consortium, The Danish RA Genetics Working Group & The Swedish Rheumatology Quality Register Biobank Study Group (SRQb) 2022, ' Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset ', Annals of the Rheumatic Diseases, vol. 81, no. 8, pp. 1085-1095 . https://doi.org/10.1136/annrheumdis-2021-221754
Annals of the Rheumatic Diseases
Saevarsdottir, S, Stefansdottir, L, Sulem, P, Thorleifsson, G, Ferkingstad, E, Rutsdottir, G, Glintborg, B, Westerlind, H, Grondal, G, Loft, I C, Sorensen, S B, Lie, B A, Brink, M, Ärlestig, L, Arnthorsson, A O, Baecklund, E, Banasik, K, Bank, S, Bjorkman, L I, Ellingsen, T, Erikstrup, C, Frei, O, Gjertsson, I, Gudbjartsson, D F, Gudjonsson, S A, Halldorsson, G H, Hendricks, O, Hillert, J, Hogdall, E, Jacobsen, S, Jensen, D V, Jonsson, H, Kastbom, A, Kockum, I, Kristensen, S, Kristjansdottir, H, Larsen, M H, Linauskas, A, Hauge, E-M, Loft, A G, Ludviksson, B R, Lund, S H, Markusson, T, Masson, G, Melsted, P, Moore, K H S, Munk, H, Nielsen, K R, Norddahl, G L, Oddsson, A, Olafsdottir, T A, Olason, P I, Olsson, T, Ostrowski, S R, Hørslev-Petersen, K, Rognvaldsson, S, Sanner, H, Silberberg, G N, Stefansson, H, Sørensen, E, Sørensen, I J, Turesson, C, Bergman, T, Alfredsson, L, Kvien, T K, Brunak, S, Steinsson, K, Andersen, V, Andreassen, O A, Rantapää-Dahlqvist, S, Hetland, M L, Klareskog, L, Askling, J, Padyukov, L, Pedersen, O B, Thorsteinsdottir, U, Jonsdottir, I, Stefansson, K, Members of the DBDS Genomic Consortium & Nyegaard, M 2022, ' Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset ', Annals of the Rheumatic Diseases, vol. 81, no. 8, 221754, pp. 1085-1095 . https://doi.org/10.1136/annrheumdis-2021-221754
Objectives To find causal genes for rheumatoid arthritis (RA) and its seropositive (RF and/or ACPA positive) and seronegative subsets. Methods We performed a genome-wide association study (GWAS) of 31 313 RA cases (68% seropositive) and similar to 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa559b7172b3407158d15a52860ec6e
https://curis.ku.dk/portal/da/publications/multiomics-analysis-of-rheumatoid-arthritis-yields-sequence-variants-that-have-large-effects-on-risk-of-the-seropositive-subset(ac8972ce-4933-4e08-88e5-2da877e76a2b).html
https://curis.ku.dk/portal/da/publications/multiomics-analysis-of-rheumatoid-arthritis-yields-sequence-variants-that-have-large-effects-on-risk-of-the-seropositive-subset(ac8972ce-4933-4e08-88e5-2da877e76a2b).html
Autor:
Christopher A G Söderberg, Wietske Lambert, Sven Kjellström, Alena Wiegandt, Ragna Peterson Wulff, Cecilia Månsson, Gudrun Rutsdottir, Cecilia Emanuelsson
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38927 (2012)
Lysine-specific chemical crosslinking in combination with mass spectrometry is emerging as a tool for the structural characterization of protein complexes and protein-protein interactions. After tryptic digestion of crosslinked proteins there are tho
Externí odkaz:
https://doaj.org/article/42df66698a444a6b81c119185324f8d0
Autor:
Christopher A. G. Söderberg, Wietske Lambert, Sven Kjellström, Alena Wiegandt, Ragna Peterson Wulff, Cecilia Månsson, Gudrun Rutsdottir, Cecilia Emanuelsson
Publikováno v:
PLoS ONE, Vol 7, Iss 8 (2012)
Externí odkaz:
https://doaj.org/article/e5746a4113e347d2a5f758a86be05701
Autor:
Gyda Bjornsdottir, Gudrun Rutsdottir, Agnar Helgason, Muhammad Sulaman Nawaz, Gudny A. Arnadottir, Gudmundur L. Norddahl, Bjarni V. Halldorsson, Ragnar P. Kristjansson, Gudmundur Thorgeirsson, Gardar Sveinbjornsson, Rosa S. Gisladottir, Lina Jonsson, Daniel F. Gudbjartsson, Astros Skuladottir, Vinicius Tragante, Hreinn Stefansson, Erna V. Ivarsdottir, Ingileif Jonsdottir, Hannes Helgason, Hilma Holm, Nanna K. Hannesdottir, Asmundur Oddsson, Kari Stefansson, Patrick Sulem, Magnus O. Ulfarsson, Thorgeir E. Thorgeirsson, Benedikt Atli Jónsson, Unnur Thorsteinsdottir
Publikováno v:
Current biology : CB. 30(23)
Summary Olfactory receptor (OR) genes in humans form a special class characterized by unusually high DNA sequence diversity, which should give rise to differences in perception and behavior. In the largest genome-wide association study to date based
Autor:
Christopher A. G. Söderberg, Morten Rasmussen, Cecilia Månsson, Peter Højrup, Sreekanth Rajan, Johan Härmark, Cecilia Emanuelsson, Gudrun Rutsdottir, Hans Hebert, Katja Bernfur, Salam Al-Karadaghi
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Scientific Reports
Söderberg, C A G, Månsson, C, Bernfur, K, Rutsdottir, G, Härmark, J, Rajan, S, Al-Karadaghi, S, Rasmussen, M, Höjrup, P, Hebert, H & Emanuelsson, C 2018, ' Structural modelling of the DNAJB6 oligomeric chaperone shows a peptide-binding cleft lined with conserved S/T-residues at the dimer interface ', Scientific Reports, vol. 8, 5199 . https://doi.org/10.1038/s41598-018-23035-9
Scientific Reports
Söderberg, C A G, Månsson, C, Bernfur, K, Rutsdottir, G, Härmark, J, Rajan, S, Al-Karadaghi, S, Rasmussen, M, Höjrup, P, Hebert, H & Emanuelsson, C 2018, ' Structural modelling of the DNAJB6 oligomeric chaperone shows a peptide-binding cleft lined with conserved S/T-residues at the dimer interface ', Scientific Reports, vol. 8, 5199 . https://doi.org/10.1038/s41598-018-23035-9
The remarkably efficient suppression of amyloid fibril formation by the DNAJB6 chaperone is dependent on a set of conserved S/T-residues and an oligomeric structure, features unusual among DNAJ chaperones. We explored the structure of DNAJB6 using a
Publikováno v:
Protein Science. 26:1773-1784
The small heat shock protein (sHsp) chaperones are crucial for cell survival and can prevent aggregation of client proteins that partially unfold under destabilizing conditions. Most investigations on the chaperone activity of sHsps are based on a li
Autor:
Morten Rasmussen, Peter Højrup, Katja Bernfur, Gudrun Rutsdottir, Christopher A. G. Söderberg, Cecilia Emanuelsson
Publikováno v:
Rutsdottir, G, I Rasmussen, M, Hojrup, P, Bernfur, K, Emanuelsson, C & Söderberg, C A G 2018, ' Chaperone-client interactions between Hsp21 and client proteins monitored in solution by small angle X-ray scattering and captured by crosslinking mass spectrometry ', Proteins, vol. 86, no. 1, pp. 110-123 . https://doi.org/10.1002/prot.25413
The small heat shock protein (sHsp) chaperones are important for stress survival, yet the molecular details of how they interact with client proteins are not understood. All sHsps share a folded middle domain to which is appended flexible N- and C-te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ce04c52c1f9594bcf9c8f4d1b4b4256
https://portal.findresearcher.sdu.dk/da/publications/5b171911-901e-46fe-99e1-fdbbdfdfa5c7
https://portal.findresearcher.sdu.dk/da/publications/5b171911-901e-46fe-99e1-fdbbdfdfa5c7
Publikováno v:
Protein Science : A Publication of the Protein Society
The small heat shock protein (sHsp) chaperones are crucial for cell survival and can prevent aggregation of client proteins that partially unfold under destabilizing conditions. Most investigations on the chaperone activity of sHsps are based on a li
Autor:
Johan Härmark, Yoran Weide, Michal Respondek, Peter Højrup, Hans Hebert, Christopher A. G. Söderberg, Cecilia Emanuelsson, Mikael Akke, Gudrun Rutsdottir, Morten Rasmussen, Sven Wernersson, Philip J.B. Koeck
Publikováno v:
The Journal of Biological Chemistry
Rutsdottir, G, Härmark, J, Weide, Y, Hebert, H, Rasmussen, M I, Wernersson, S, Respondek, M, Akke, M, Højrup, P, Koeck, P J B, Söderberg, C A G & Emanuelsson, C 2017, ' Structural model of dodecameric heat-shock protein Hsp21 : Flexible N-terminal arms interact with client proteins while C-terminal tails maintain the dodecamer and chaperone activity ', Journal of Biological Chemistry, vol. 292, no. 19, pp. 8103-8121 . https://doi.org/10.1074/jbc.M116.766816
Rutsdottir, G, Härmark, J, Weide, Y, Hebert, H, Rasmussen, M I, Wernersson, S, Respondek, M, Akke, M, Højrup, P, Koeck, P J B, Söderberg, C A G & Emanuelsson, C 2017, ' Structural model of dodecameric heat-shock protein Hsp21 : Flexible N-terminal arms interact with client proteins while C-terminal tails maintain the dodecamer and chaperone activity ', Journal of Biological Chemistry, vol. 292, no. 19, pp. 8103-8121 . https://doi.org/10.1074/jbc.M116.766816
Small heat-shock proteins (sHsps) prevent aggregation of thermosensitive client proteins in a first line of defense against cellular stress. The mechanisms by which they perform this function have been hard to define due to limited structural informa