Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Gudrun, Knuebel"'
Autor:
Anna Richter, Sandra Lange, Clemens Holz, Luisa Brock, Thomas Freitag, Anett Sekora, Gudrun Knuebel, Saskia Krohn, Rico Schwarz, Burkhard Hinz, Hugo Murua Escobar, Christian Junghanss
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract Dysregulation of the intrinsic BCL-2 pathway-mediated apoptosis cascade is a common feature of hematological malignancies including acute B-lymphoblastic leukemia (B-ALL). The KMT2A-rearranged high-risk cytogenetic subtype is characterized b
Externí odkaz:
https://doaj.org/article/f965715f9603445aaf305e682578afd1
Autor:
Luise Grunwald, Christina Grosse-Thie, Sina Sender, Gudrun Knuebel, Saskia Krohn, Catrin Roolf, Christian Junghanss, Larissa Henze, Hugo Murua Escobar
Publikováno v:
Biomarker Research, Vol 8, Iss 1, Pp 1-4 (2020)
Abstract Myeloproliferative neoplasms are characterized by mutations in JAK2, MPL and CALR genes. Commonly in diagnostics and previous studies mainly sequencing and common PCR techniques under conventional detection limits are used. Splanchnic vein t
Externí odkaz:
https://doaj.org/article/cdfa19447b6e45e0b7b5beb463afe6ca
Autor:
Anna Richter, Sina Sender, Annemarie Lenz, Rico Schwarz, Burkhard Hinz, Gudrun Knuebel, Anett Sekora, Hugo Murua Escobar, Christian Junghanss, Catrin Roolf
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-10 (2020)
Abstract Background Casein kinase II (CK2) is involved in multiple tumor-relevant signaling pathways affecting proliferation and apoptosis. CK2 is frequently upregulated in acute B-lymphoblastic leukemia (B-ALL) and can be targeted by the ATP-competi
Externí odkaz:
https://doaj.org/article/bf338d2f4e8c4aaaafa01b0ae93d5af2
Autor:
Christin Völkner, Maik Liedtke, Janine Petters, Jan Lukas, Hugo Murua Escobar, Gudrun Knuebel, Jörn Bullerdiek, Carsten Holzmann, Andreas Hermann, Moritz J. Frech
Publikováno v:
Stem Cell Research, Vol 50, Iss , Pp 102127- (2021)
Niemann-Pick disease Type C (NPC) is a rare progressive neurodegenerative disorder with an incidence of 1:120,000 caused by mutations in the NPC1 or NPC2 gene leading to a massive cholesterol accumulation. Here, we describe the generation of induced
Externí odkaz:
https://doaj.org/article/2c0a50745eb84a2783f884c33d53361c
Autor:
Christin Völkner, Maik Liedtke, Janine Petters, Katharina Huth, Gudrun Knuebel, Hugo Murua Escobar, Jörn Bullerdiek, Jan Lukas, Andreas Hermann, Moritz J. Frech
Publikováno v:
Stem Cell Research, Vol 49, Iss , Pp 102056- (2020)
Niemann-Pick disease type C1 (NPC1) is a rare inherited lipid storage disorder caused by mutations in the NPC1 gene. Mutations lead to impaired lipid trafficking and subsequently to accumulation of cholesterol and sphingolipids. NPC1-patients present
Externí odkaz:
https://doaj.org/article/d99d3150ea374e94995b0502099a7fdc
Autor:
Janine Petters, Chiara Cimmaruta, Katharina Iwanov, Matthew L. Chang, Christin Völkner, Gudrun Knuebel, Hugo Murua Escobar, Moritz J. Frech, Andreas Hermann, Arndt Rolfs, Jan Lukas
Publikováno v:
Stem Cell Research, Vol 43, Iss , Pp - (2020)
Wilson disease (WD) is an inherited, autosomal recessive disorder of copper metabolism caused by mutations in the ATP7B gene. Pathogenic single nucleotide variants (SNVs) lead to functional impairment of the copper transporting ATPase ATP7B, resultin
Externí odkaz:
https://doaj.org/article/6957b5486146465e8e13817aeeb774b6
Autor:
Anna Richter, Catrin Roolf, Anett Sekora, Gudrun Knuebel, Saskia Krohn, Sandra Lange, Vivien Krebs, Bjoern Schneider, Johannes Lakner, Christoph Wittke, Christoph Kiefel, Irmela Jeremias, Hugo Murua Escobar, Brigitte Vollmar, Christian Junghanss
Publikováno v:
Cells, Vol 11, Iss 1, p 150 (2022)
In acute lymphoblastic leukemia (ALL), conventional cell lines do not recapitulate the clonal diversity and microenvironment. Orthotopic patient-derived xenograft models (PDX) overcome these limitations and mimic the clinical situation, but molecular
Externí odkaz:
https://doaj.org/article/21fdd92f54984c47a5294b6e0d5b6d24
Autor:
Gudrun Knuebel, Christian Junghanss, Hugo Murua Escobar, Christina Grosse-Thie, Catrin Roolf, Luise Grunwald, Sina Sender, Larissa Henze, Saskia Krohn
Publikováno v:
Biomarker Research, Vol 8, Iss 1, Pp 1-4 (2020)
Biomarker Research
Biomarker Research
Myeloproliferative neoplasms are characterized by mutations in JAK2, MPL and CALR genes. Commonly in diagnostics and previous studies mainly sequencing and common PCR techniques under conventional detection limits are used. Splanchnic vein thromboses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f96307c8bab894e20d753f8c5d9872
https://doaj.org/article/cdfa19447b6e45e0b7b5beb463afe6ca
https://doaj.org/article/cdfa19447b6e45e0b7b5beb463afe6ca
Autor:
Moritz J. Frech, Christin Völkner, Andreas Hermann, Jörn Bullerdiek, Gudrun Knuebel, Maik Liedtke, Katharina Huth, Janine Petters, Jan Lukas, Hugo Murua Escobar
Publikováno v:
Stem Cell Research, Vol 49, Iss, Pp 102056-(2020)
Stem cell research 49, 102056 (2020). doi:10.1016/j.scr.2020.102056
Stem cell research 49, 102056 (2020). doi:10.1016/j.scr.2020.102056
Niemann-Pick disease type C1 (NPC1) is a rare inherited lipid storage disorder caused by mutations in the NPC1 gene. Mutations lead to impaired lipid trafficking and subsequently to accumulation of cholesterol and sphingolipids. NPC1-patients present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e06f2b448a2bfeb1b233f0a6da6f438a
http://www.sciencedirect.com/science/article/pii/S1873506120303573
http://www.sciencedirect.com/science/article/pii/S1873506120303573
Autor:
Gudrun Knuebel, Rico Schwarz, Burkhard Hinz, Catrin Roolf, Christian Junghanss, Annemarie Lenz, Sina Sender, Anna Richter, Hugo Murua Escobar, Anett Sekora
Publikováno v:
BMC Cancer
BMC Cancer, Vol 20, Iss 1, Pp 1-10 (2020)
BMC Cancer, Vol 20, Iss 1, Pp 1-10 (2020)
Background Casein kinase II (CK2) is involved in multiple tumor-relevant signaling pathways affecting proliferation and apoptosis. CK2 is frequently upregulated in acute B-lymphoblastic leukemia (B-ALL) and can be targeted by the ATP-competitive CK2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0037f3fcdae67a1bb195f8147c3bab16
http://europepmc.org/articles/PMC7057698
http://europepmc.org/articles/PMC7057698