Arrhythmogenic Mechanisms in Heart Failure: Linking β-Adrenergic Stimulation, Stretch, and Calcium

Autor: Daniel M. Johnson, Gudrun Antoons

Publikováno v: Frontiers in Physiology, Vol 9 (2018)

Heart failure (HF) is associated with elevated sympathetic tone and mechanical load. Both systems activate signaling transduction pathways that increase cardiac output, but eventually become part of the disease process itself leading to further worse

Externí odkaz: https://doaj.org/article/db6e20e6329b4dc0b569740d0bba0a2d

A two dimensional electromechanical model of a cardiomyocyte to assess intra-cellular regional mechanical heterogeneities.

Autor: Patricia Garcia-Canadilla, Jose F Rodriguez, Maria J Palazzi, Anna Gonzalez-Tendero, Patrick Schönleitner, Vedrana Balicevic, Sven Loncaric, Joost J F P Luiken, Mario Ceresa, Oscar Camara, Gudrun Antoons, Fatima Crispi, Eduard Gratacos, Bart Bijnens

Publikováno v: PLoS ONE, Vol 12, Iss 8, p e0182915 (2017)

Experimental studies on isolated cardiomyocytes from different animal species and human hearts have demonstrated that there are regional differences in the Ca2+ release, Ca2+ decay and sarcomere deformation. Local deformation heterogeneities can occu

Externí odkaz: https://doaj.org/article/c1b320ee731b44e38332c55f99974972

Inotropic effect of NCX inhibition depends on the relative activity of the reverse NCX assessed by a novel inhibitor ORM-10962 on canine ventricular myocytes

Autor: Gudrun Antoons, Norbert Nagy, Károly Acsai, Piero Pollesello, Zsófia Kohajda, Jouko Levijoki, Kinga Oravecz, Zoltán Márton, Norbert Jost, Leila Mirzaei, Tuula Koskelainen, Andrea Gruber, Péter P. Nánási, András Varró, András Tóth, Leena Otsomaa, Julius Gy. Papp, Anita Kormos

Publikováno v: European Journal of Pharmacology, 818, 278-286. Elsevier Science

Na+/Ca2+ exchanger (NCX) is the main Ca2+ transporter in cardiac myocytes. Its inhibition could be expected to exert positive inotropic action by accumulation of cytosolic Ca2+ ([Ca2+](i)). However, we have observed only a marginal positive inotropic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::794f1ca31692a9b9eaa8e25e2cde5d94
https://doi.org/10.1016/j.ejphar.2017.10.039

Palmitate-Induced Vacuolar-Type H(+)-ATPase Inhibition Feeds Forward Into Insulin Resistance and Contractile Dysfunction

Autor: Laura K.M. Steinbusch, Joost J. F. P. Luiken, Dimitris Kapsokalyvas, Gudrun Antoons, Dipanjan Chanda, Jan F. C. Glatz, Amber Geomini, Yilin Liu, Peter J. Simons, Miranda Nabben, Patrick Schönleitner, Dietbert Neumann, Marc A. M. J. van Zandvoort, Will A. Coumans

Publikováno v: Diabetes, 66(6), 1521-1534. American Diabetes Association

Dietary fat overconsumption leads to myocardial lipid accumulation through mechanisms that are incompletely resolved. Previously, we identified increased translocation of the fatty acid transporter CD36 from its endosomal storage compartment to the s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f5e237eee3ae5a4a39d5deaa80bec5f
https://doi.org/10.2337/db16-0727

The European Network for Translational Research in Atrial Fibrillation (EUTRAF): objectives and initial results

Autor: David Cartlidge, Ulrich Schotten, Dobromir Dobrev, Andres Goette, Ursula Ravens, Ali Oto, Klaus Steinmeyer, Thorsten Götsche, Uwe Lendeckel, Stephan Rohr, Paulus Kirchhof, Pierre Jaïs, Jens Kockskämper, F.U. Müller, Barbara Casadei, Gudrun Antoons, Burkert Pieske, Stéphane N. Hatem, Sander Verheule, Larissa Fabritz, Daniel Scherr, A. John Camm

Publikováno v: EP Europace, 17(10), 1457-1466. Oxford University Press
Schotten, Ulrich; Hatem, Stephane; Ravens, Ursula; Jaïs, Pierre; Müller, Frank-Ulrich; Goette, Andres; Rohr, Stephan; Antoons, Gudrun; Pieske, Burkert; Scherr, Daniel; Oto, Ali; Casadei, Barbara; Verheule, Sander; Cartlidge, David; Steinmeyer, Klaus; Götsche, Thorsten; Dobrev, Dobromir; Kockskämper, Jens; Lendeckel, Uwe; Fabritz, Larissa; ... (2015). The European Network for Translational Research in Atrial Fibrillation (EUTRAF): objectives and initial results. Europace, 17(10), pp. 1457-1466. Oxford University Press 10.1093/europace/euv252

Atrial fibrillation (AF) is the most common sustained arrhythmia in the general population. As an age-related arrhythmia AF is becoming a huge socio-economic burden for European healthcare systems. Despite significant progress in our understanding of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4992ea649f6cd4e130e1aa1f8057e40
https://cris.maastrichtuniversity.nl/en/publications/b013569a-995e-48f2-ad3b-f8bb68afd24e