Immunization of mice with the nef gene from Human Immunodeficiency Virus type 1: Study of immunological memory and long-term toxicology

Autor: Engström Gunnel, Boberg Andreas, Rollman Erik, Kastenmuller Wolfgang, Hallermalm Kristian, Gasteiger Georg, Gudmundsdotter Lindvi, Bråve Andreas, Reiland Sven, Cosma Antonio, Drexler Ingo, Hinkula Jorma, Wahren Britta, Erfle Volker

Publikováno v: Infectious Agents and Cancer, Vol 2, Iss 1, p 14 (2007)

Abstract Background The human immunodeficiency virus type 1 (HIV-1) regulatory protein, Nef, is an attractive vaccine target because it is involved in viral pathogenesis, is expressed early in the viral life cycle and harbors many T and B cell epitop

Externí odkaz: https://doaj.org/article/2adbc09deead4653ba92a3a8b44da27e

Inhibition of IL17A Using an Affibody Molecule Attenuates Inflammation in ApoE-Deficient Mice

Autor: Kumawat, Ashok Kumar, Zegeye, Mulugeta M., Paramel, Geena Varghese, Baumgartner, Roland, Gisterå, Anton, Amegavie, Obed, Hellberg, Sanna, Jin, Hong, Caravaca, April S., Söderström, Leif Å., Gudmundsdotter, Lindvi, Frejd, Fredrik Y., Ljungberg, Liza U., Olofsson, Peder S., Ketelhuth, Daniel F. J., Sirsjö, Allan

Publikováno v: Kumawat, A K, Zegeye, M M, Paramel, G V, Baumgartner, R, Gisterå, A, Amegavie, O, Hellberg, S, Jin, H, Caravaca, A S, Söderström, L Å, Gudmundsdotter, L, Frejd, F Y, Ljungberg, L U, Olofsson, P S, Ketelhuth, D F J & Sirsjö, A 2022, ' Inhibition of IL17A Using an Affibody Molecule Attenuates Inflammation in ApoE-Deficient Mice ', Frontiers in Cardiovascular Medicine, vol. 9, 831039 . https://doi.org/10.3389/fcvm.2022.831039

The balance between pro- and anti-inflammatory cytokines released by immune and non-immune cells plays a decisive role in the progression of atherosclerosis. Interleukin (IL)-17A has been shown to accelerate atherosclerosis. In this study, we investi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::cfaf9c6b9165d04a81ab84c2a15b7856
https://findresearcher.sdu.dk:8443/ws/files/200344747/Open_Access_Version.pdf

Inhibiting HER3-Mediated Tumor Cell Growth with Affibody Molecules Engineered to Low Picomolar Affinity by Position-Directed Error-Prone PCR-Like Diversification

Autor: Malm, Magdalena, Kronqvist, Nina, Lindberg, Hanna, Gudmundsdotter, Lindvi, Bass, Tarek, Frejd, Fredrik Y., Hoiden-Guthenberg, Ingmarie, Varasteh, Zohreh, Orlova, Anna, Tolmachev, Vladimir, Stahl, Stefan, Lofblom, John

The HER3 receptor is implicated in the progression of various cancers as well as in resistance to several currently used drugs, and is hence a potential target for development of new therapies. We have previously generated Affibody molecules that inh

Externí odkaz: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-202922

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Therapeutic immunization for HIV.

Autor: Gudmundsdotter, Lindvi¹, Sjödin, Anna¹, Boström, Ann-Charlotte², Hejdeman, Bo³, Theve-Palm, Rebecca⁴, Alaeus, Annette⁴, Lidman, Knut⁴, Wahren, Britta^1,2 Britta.Wahren@smi.ki.se

Publikováno v: Springer Seminars in Immunopathology. Nov2006, Vol. 28 Issue 3, p221-230. 10p. 2 Charts, 4 Graphs.