Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects

Autor: Hans Bisgaard, Leon Eyrich Jessen, John G. Logan, Gudmar Porleifsson, Hou-Feng Zheng, Annelies C. Ham, Tarunveer S. Ahluwalia, Struan F.A. Grant, Yongmei Liu, M. Carola Zillikens, Ivana Nedeljkovic, Mattias Lorentzon, Daniel S. Evans, Kari Stefansson, Jing Hua Zhao, Gunnar Sigurdsson, Fiona E. McGuigan, Rebecca D. Jackson, Douglas P. Kiel, M. Arfan Ikram, David Karasik, J. Brent Richards, Scott Wilson, Tamara B. Harris, Najaf Amin, James F. Wilson, Peter I. Croucher, John A Robbins, Carolina Medina-Gomez, Raimo Joro, Frances M K Williams, Stuart H. Ralston, Unnur Styrkarsdottir, Timo A. Lakka, Jian'an Luan, Cheryl L. Ackert-Bicknell, John P. Walsh, Benjamin H. Mullin, Fernando Pires Hartwig, Bruce M. Psaty, Robert A. Scott, Claes Ohlsson, Janine F. Felix, Bram C. J. van der Eerden, Jonathan H Tobias, Mike A. Nalls, Christian J. Carlsson, Cindy G. Boer, Kun Zhu, Tim D. Spector, Linda Broer, Babette S. Zemel, Martin den Heijer, Mustafa Atalay, Eric S. Orwoll, David M. Evans, Ruifang Li-Gao, John P. Kemp, Katharina E. Schraut, Dennis O. Mook-Kanamori, Kristina Åkesson, Katerina Trajanoska, Maria Nethander, Evangelia E. Ntzani, Cornelia M. van Duijn, Craig E. Pennell, Yanhua Zhou, Ching-Ti Liu, Vincenzo Forgetta, Claudia Langenberg, Fernando Rivadeneira, Vincent W. V. Jaddoe, Nathalie van der Velde, J. H. Duncan Bassett, Bernardo L. Horta, Jeroen van de Peppel, Samuel K. Handelman, Evangelos Evangelou, Klaus Bønnelykke, Renée de Mutsert, Denise H. M. Heppe, Nicholas J. Wareham, Graham R. Williams, Bo L. Chawes, Andre J. van Wijnen, Carol A. Wang, Mohsen Ghanbari, Alessandra Chesi, André G. Uitterlinden

Publikováno v: Medina-Gomez, C, Kemp, J P, Trajanoska, K, Luan, J, Chesi, A, Ahluwalia, T S, Mook-Kanamori, D O, Ham, A, Hartwig, F P, Evans, D S, Joro, R, Nedeljkovic, I, Zheng, H-F, Zhu, K, Atalay, M, Liu, C-T, Nethander, M, Broer, L, Porleifsson, G, Mullin, B H, Handelman, S K, Nalls, M A, Jessen, L E, Heppe, D H M, Richards, J B, Wang, C, Chawes, B, Schraut, K E, Amin, N, Wareham, N, Karasik, D, Van der Velde, N, Ikram, M A, Zemel, B S, Zhou, Y, Carlsson, C J, Liu, Y, McGuigan, F E, Boer, C G, Bonnelykke, K, Ralston, S H, Robbins, J A, Walsh, J P, Zillikens, M C, Langenberg, C, Li-Gao, R, Williams, F M K, Harris, T B, Akesson, K, Jackson, R D, Sigurdsson, G, den Heijer, M, van der Eerden, B C J, van de Peppel, J, Spector, T D, Pennell, C, Horta, B L, Felix, J F, Zhao, J H, Wilson, S G, de Mutsert, R, Bisgaard, H, Styrkarsdottir, U, Jaddoe, V W, Orwoll, E, Lakka, T A, Scott, R, Grant, S F A, Lorentzon, M, van Duijn, C M, Wilson, J F, Stefansson, K, Psaty, B M, Kiel, D P, Ohlsson, C, Ntzani, E, van Wijnen, A J, Forgetta, V, Ghanbari, M, Logan, J G, Williams, G R, Bassett, J H D, Croucher, P I, Evangelou, E, Uitterlinden, A G, Ackert-Bicknell, C L, Tobias, J H, Evans, D M & Rivadeneira, F 2018, ' Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects ', American journal of human genetics, vol. 102, no. 1, pp. 88-102 . https://doi.org/10.1016/j.ajhg.2017.12.005
American Journal of Human Genetics, 102(1), 88-102. Cell Press
Medina-Gomez, C, Kemp, J P, Trajanoska, K, Luan, J, Chesi, A, Ahluwalia, T S, Mook-Kanamori, D O, Ham, A, Hartwig, F P, Evans, D S, Joro, R, Nedeljkovic, I, Zheng, H-F, Zhu, K, Atalay, M, Liu, C-T, Nethander, M, Broer, L, Porleifsson, G, Mullin, B H, Handelman, S K, Nalls, M A, Jessen, L E, Heppe, D H M, Richards, J B, Wang, C, Chawes, B, Schraut, K E, Amin, N, Wareham, N, Karasik, D, Van der Velde, N, Ikram, M A, Zemel, B S, Zhou, Y, Carlsson, C J, Liu, Y, McGuigan, F E, Boer, C G, Bønnelykke, K, Ralston, S H, Robbins, J A, Walsh, J P, Zillikens, M C, Langenberg, C, Li-Gao, R, Williams, F M K, Harris, T B, Akesson, K, Jackson, R D, Sigurdsson, G, den Heijer, M, van der Eerden, B C J, van de Peppel, J, Spector, T D, Pennell, C, Horta, B L, Felix, J F, Zhao, J H, Wilson, S G, de Mutsert, R, Bisgaard, H, Styrkársdóttir, U, Jaddoe, V W, Orwoll, E, Lakka, T A, Scott, R, Grant, S F A, Lorentzon, M, van Duijn, C M, Wilson, J F, Stefansson, K, Psaty, B M, Kiel, D P, Ohlsson, C, Ntzani, E, van Wijnen, A J, Forgetta, V, Ghanbari, M, Logan, J G, Williams, G R, Bassett, J H D, Croucher, P I, Evangelou, E, Uitterlinden, A G, Ackert-Bicknell, C L, Tobias, J H, Evans, D M & Rivadeneira, F 2018, ' Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects ', American Journal of Human Genetics, vol. 102, no. 1, pp. 88-102 . https://doi.org/10.1016/j.ajhg.2017.12.005
American Journal of Human Genetics, 102(1), 88-102
Medina-Gomez, C, Kemp, J P, Trajanoska, K, Luan, J, Chesi, A, Ahluwalia, T S, Mook-Kanamori, D O, Ham, A, Hartwig, F P, Evans, D S, Joro, R, Nedeljkovic, I, Zheng, H F, Zhu, K, Atalay, M, Liu, C T, Nethander, M, Broer, L, Porleifsson, G, Mullin, B H, Handelman, S K, Nalls, M A, Jessen, L E, Heppe, D H M, Richards, J B, Wang, C, Chawes, B, Schraut, K E, Amin, N, Wareham, N, Karasik, D, Van der Velde, N, Ikram, M A, Zemel, B S, Zhou, Y, Carlsson, C J, Liu, Y, McGuigan, F E, Boer, C G, Bønnelykke, K, Ralston, S H, Robbins, J A, Walsh, J P, Zillikens, M C, Langenberg, C, Li-Gao, R, Williams, F M K, Harris, T B, Akesson, K, Jackson, R D, Sigurdsson, G, den Heijer, M, van der Eerden, B C J, van de Peppel, J, Spector, T D, Pennell, C, Horta, B L, Felix, J F, Zhao, J H, Wilson, S G, de Mutsert, R, Bisgaard, H, Styrkársdóttir, U, Jaddoe, V W, Orwoll, E, Lakka, T A, Scott, R, Grant, S F A, Lorentzon, M, van Duijn, C M, Wilson, J F, Stefansson, K, Psaty, B M, Kiel, D P, Ohlsson, C, Ntzani, E, van Wijnen, A J, Forgetta, V, Ghanbari, M, Logan, J G, Williams, G R, Bassett, J H D, Croucher, P I, Evangelou, E, Uitterlinden, A G, Ackert-Bicknell, C L, Tobias, J H, Evans, D M & Rivadeneira, F 2018, ' Life-course genome-wide association study meta-analysis of total body BMD and assessment of age-specific effects ', American Journal of Human Genetics, vol. 102, no. 1, pp. 88-102 . https://doi.org/10.1016/j.ajhg.2017.12.005
American journal of human genetics, 102(1), 88-102. Cell Press
American journal of human genetics, vol 102, iss 1
American Journal of Human Genetics
The American Journal of Human Genetics

Bone mineral density (BMD) assessed by DXA is used to evaluate bone health. In children, total body (TB) measurements are commonly used; in older individuals, BMD at the lumbar spine (LS) and femoral neck (FN) is used to diagnose osteoporosis. To dat

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https://research.vumc.nl/en/publications/b47f10ea-5069-4e9c-80bd-d202f4dfe7f3