Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Guat Ling Lee"'
Autor:
Guat Ling Lee, Maksims Yevglevskis, Tony D. James, Amit Nathubhai, Michael D. Threadgill, Timothy J. Woodman, Matthew D. Lloyd, Yoana D. Petrova
Publikováno v:
Jevglevskis, M, Lee, G L, Nathubhai, A, Petrova, Y, James, T, Threadgill, M, Woodman, T & Lloyd, M 2018, ' Structure-activity relationships of rationally designed AMACR 1A inhibitors ', Bioorganic and Medicinal Chemistry, vol. 79, pp. 145-154 . https://doi.org/10.1016/j.bioorg.2018.04.024
α-Methylacyl-CoA racemase (AMACR; P504S) is a promising novel drug target for prostate and other cancers. Assaying enzyme activity is difficult due to the reversibility of the ‘racemisation’ reaction and the difficulties in the separation of epi
Autor:
P J Mitchell, Matthew D. Lloyd, Tony D. James, Michael D. Threadgill, Suzanne Al-Rawi, Timothy J. Woodman, Maksims Yevglevskis, Tingying Jiao, Guat Ling Lee, Katty Wadda, Amit Nathubhai
Publikováno v:
Jevglevskis, M, Nathubhai, A, Wadda, K, Lee, G L, Al-Rawi, S, Jiao, T, Mitchell, P, James, T, Threadgill, M, Woodman, T & Lloyd, M 2019, ' Novel 2-arylthiopropanoyl-CoA inhibitors of α-methylacyl-CoA racemase 1A (AMACR; P504S) as potential anti-prostate cancer agents ', Bioorganic Chemistry, vol. 92, 103263 . https://doi.org/10.1016/j.bioorg.2019.103263
α-Methylacyl-CoA racemase (AMACR; P504S) catalyses an essential step in the degradation of branched-chain fatty acids and the activation of ibuprofen and related drugs. AMACR has gained much attention as a drug target and biomarker, since it is foun
Autor:
Tony D. James, Matthew D. Lloyd, Guat Ling Lee, Maksims Yevglevskis, Michael D. Threadgill, Yoana D. Petrova, Amit Nathubhai, Timothy J. Woodman
alpha-Methylacyl-CoA racemase (AMACR; P504S) regulates branchedchain\ud fatty acid degradation, activates Ibuprofen and is a recognised\ud cancer drug target. A novel, facile colorimetric assay was developed\ud based on elimination of 2,4-dinitrophen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34fde5572e00a8bccd7a2cd60fa69dc6
https://orca.cardiff.ac.uk/id/eprint/133378/1/c7cc00476a.pdf
https://orca.cardiff.ac.uk/id/eprint/133378/1/c7cc00476a.pdf
Autor:
Guat Ling Lee, Maksims Yevglevskis, Pauline J. Wood, Timothy J. Woodman, Michael D. Threadgill, Matthew D. Lloyd
Publikováno v:
Progress in Lipid Research. 52:220-230
α-Methylacyl-CoA racemase (AMACR; P504S) catalyzes a key chiral inversion step in the metabolism of branched-chain fatty acids, ibuprofen and related drugs. Protein levels are increased in all prostate and some other cancer cells and it is used as a
Autor:
Guat Ling Lee, Shiyi Zhou, Xiaolong Sun, Tony D. James, Matthew D. Lloyd, Timothy J. Woodman, Gabriele Kociok-Köhn, Maksims Yevglevskis, Jenny Sun
Publikováno v:
Jevglevskis, M, Lee, G L, Sun, J, Zhou, S, Sun, X, Kociok-Kohn, G, James, T D, Woodman, T J & Lloyd, M D 2016, ' A study on the AMACR catalysed elimination reaction and its application to inhibitor testing ', Organic and Biomolecular Chemistry, vol. 14, no. 2, pp. 612-622 . https://doi.org/10.1039/C5OB01541C
α-Methylacyl-CoA racemase (AMACR; P504S) catalyses a key step in the degradation of branched-chain fatty acids and is important for the pharmacological activation of Ibuprofen and related drugs. Levels of AMACR are increased in prostate and other ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b5828fd1fb3fa91519f96f56c86d96c
https://purehost.bath.ac.uk/ws/files/140002896/Published_Version.pdf
https://purehost.bath.ac.uk/ws/files/140002896/Published_Version.pdf
Autor:
Maksims Yevglevskis, Guat Ling Lee, Timothy J. Woodman, Michael D. Threadgill, Matthew D. Lloyd
Publikováno v:
Jevglevskis, M, Lee, G L, Threadgill, M D, Woodman, T J & Lloyd, M D 2014, ' The perils of rational design – unexpected irreversible elimination of fluoride from 3-fluoro-2-methylacyl-CoA esters catalysed by α-methylacyl-CoA racemase (AMACR; P504S) ', Chemical Communications, vol. 50, no. 91, pp. 14164-14166 . https://doi.org/10.1039/C4CC06127F
α-Methylacyl-CoA racemase (AMACR; P504S) catalyses ‘racemization’ of 2-methylacyl-CoAs, the activation of R-ibuprofen and is a promising cancer drug target. Human recombinant AMACR 1A catalyses elimination of 3-fluoro-2-methyldecanoyl-CoAs to gi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc898b82a773303a01a42ff5573026e6
https://purehost.bath.ac.uk/ws/files/112735163/Accepted_version.pdf
https://purehost.bath.ac.uk/ws/files/112735163/Accepted_version.pdf
Publikováno v:
The Journal of antimicrobial chemotherapy. 66(11)
There is growing evidence to suggest that biofilms may be involved in the aetiology of chronic wounds. The development of formulations with enhanced anti-biofilm activity could therefore represent a potential therapeutic strategy by reducing bioburde