Discovery and Optimization of Pyridazinones as PI3Kδ Selective Inhibitors for Administration by Inhalation.

Autor: Bruno P; Medicinal Chemistry and Drug Design Technologies Department, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy., Micoli A; Drug Discovery Chemistry Department, Aptuit, an Evotec Company, Via A. Fleming 4, 37135 Verona, Italy., Corsi M; In Vitro Biology Department, Aptuit, an Evotec Company, Via A. Fleming 4, 37135 Verona, Italy., Pala D; Medicinal Chemistry and Drug Design Technologies Department, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy., Guariento S; Medicinal Chemistry and Drug Design Technologies Department, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy., Fiorelli C; Medicinal Chemistry and Drug Design Technologies Department, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy., Ronchi P; Medicinal Chemistry and Drug Design Technologies Department, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy., Fioni A; Pharmacokinetics Biochemistry Metabolism Department, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy., Gallo PM; Pharmacokinetics Biochemistry Metabolism Department, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy., Marenghi G; Pharmacokinetics Biochemistry Metabolism Department, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy., Bertolini S; Pharmacology Department, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy., Capacchi S; Medicinal Chemistry and Drug Design Technologies Department, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy., Mileo V; Analytics & Early Formulations Department, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy., Biagetti M; Pipeline Innovation Department, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy., Capelli AM; AIR Franchise, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Jul 11; Vol. 67 (13), pp. 11103-11124. Date of Electronic Publication: 2024 Jun 22.

Direct Decarboxylative C-2 Alkylation of Azoles through Minisci-Type Coupling.

Autor: Rosadoni E; Department of Chemistry and Industrial Chemistry, University of Pisa, Via Moruzzi 13, 56124 Pisa, Italy., Bombonato E; Department of Chemistry 'Giacomo Ciamician', Alma Mater Studiorum - University of Bologna, Via Selmi, 2, 40126 Bologna, Italy., Del Vecchio A; Department of Chemistry and Industrial Chemistry, University of Pisa, Via Moruzzi 13, 56124 Pisa, Italy., Guariento S; Chemistry Research and Drug Design, Chiesi Farmaceutici S.p.A., Centro Ricerche, Largo Belloli 11/A, 43122 Parma, Italy., Ronchi P; Chemistry Research and Drug Design, Chiesi Farmaceutici S.p.A., Centro Ricerche, Largo Belloli 11/A, 43122 Parma, Italy., Bellina F; Department of Chemistry and Industrial Chemistry, University of Pisa, Via Moruzzi 13, 56124 Pisa, Italy.

Publikováno v: The Journal of organic chemistry [J Org Chem] 2023 Oct 06; Vol. 88 (19), pp. 14236-14241. Date of Electronic Publication: 2023 Sep 20.

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Non-regioselective functionalization: an underestimate chemical diversity generator in medicinal chemistry.

Autor: Guariento S; Chemistry Research & Drug Design, Chiesi Farmaceutici S.p.A, Centro Ricerche, Largo Belloli 11/a, Parma 43122, Italy., Biagetti M; Chemistry Research & Drug Design, Chiesi Farmaceutici S.p.A, Centro Ricerche, Largo Belloli 11/a, Parma 43122, Italy., Ronchi P; Chemistry Research & Drug Design, Chiesi Farmaceutici S.p.A, Centro Ricerche, Largo Belloli 11/a, Parma 43122, Italy.

Publikováno v: Future medicinal chemistry [Future Med Chem] 2021 Apr; Vol. 13 (7), pp. 595-599. Date of Electronic Publication: 2021 Mar 04.

Health care for older people in Italy: The U.L.I.S.S.E. Project (Un link informatico sui servizi sanitari esistenti per l'anziano - a computerized network on health care services for older people)

Autor: Lattanzio F, Mussi C, Scafato E, Ruggiero C, Dell'Aquila G, Pedone C, Mammarella F, Galluzzo L, Salvioli G, Senin U, Carbonin PU, Bernabei R, Cherubini A, Laguzzi E, Cucinotta D, Arnone G, Rozzini R, Cassinadri A, Putzu P, Porceddu C, Zaru C, Abate G, Di Iorio A, Abate M, Guglielmi M, Foschini N, Battaglini C, Fellin R, Volpato S, Cavalieri M, Fotini S, Guerra G, Rossi L, Masotti G, Fumagalli S, Odetti P, Cataldi A, Monacelli F, Nicita Mauro V, Basile G, Maltese G, Nicita Mauro C, Pellicciotti F, Scotto R, Vaccina A, Minnucci A, Forte L, Lo Storoto MR, Licata G, Tuttolomondo A, Barbagallo M, Dominguez LJ, De Leo M, Belvedere M, Putignano E, Longo A, Mancioli G, Patacchini F, Palmari N, Ierardi BA, Marino P, Soldato M, Pilotto A, Paris F, Forconi S, Guerrini M, De Paduanis GA, De Palma A, Boschi S, Molaschi M, Poli L, De Colle P, Bonoldi G, Puricelli S, Pellegrini R, Consolaro E, Bosello O, Zivelonghi A, Gravic G, Guariento S, Di Francesco V, Tua E, Pisaturo A, Lacava R, Gareri P, Borgia R, Cristiano VN, Palummeri, Pescetelli, Galdi M, Bochicchio GB, Solimano A, Brugaletta S, Carnazza L, Gallitto E, Albano G, Schipani G, Conte, Pagella A, Perrero L, Sabato V, Marella L, Schiavina, Zacco B, Scaglia L, Virgilio A, Iera M, Doria, Pansini L, Boni N, Inzitari M, Aramini I, Musante S, Cavagnaro P, Riello F, De Alfieri W, Pescetelli P, Trecca R, Di Iusto, Zamboni V, Cuppone R, Foschi, Marino S, Simone M, Scarlata A, Battegazzore C, Morucci R, Luchetti M, Menculini G, Cichetti G, Orlando I, Fantoni B, Ognibene G, Gobbi C, Cascone A, Avanzi GL, Casu A, Zeni S, Santin S, Scotti G, Cappella C, Penzo P., TOIGO, GABRIELE

Objectives: The U.L.I.S.S.E. study is aimed at describing older patients who are cared for in hospitals, home care or nursing homes in Italy. Design: The U.L.I.S.S.E. study is an observational multicenter prospective 1-year study. Setting: Overall, 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dris___01099::3d9db9fe7be770910c57cc04ec2026db
https://hdl.handle.net/11368/2494341