Encapsulation of Platinum Prodrugs into PC7A Polymeric Nanoparticles Combined with Immune Checkpoint Inhibitors for Therapeutically Enhanced Multimodal Chemotherapy and Immunotherapy by Activation of the STING Pathway

Autor: Xiangjie Gao, Guanxiong Lei, Bin Wang, Zhong Deng, Johannes Karges, Haihua Xiao, Donghui Tan

Publikováno v: Advanced Science, Vol 10, Iss 4, Pp n/a-n/a (2023)

Abstract Tumor immunotherapy has emerged as one of the most promising therapeutic methods to treat cancer. Despite its clinical application, the immunosuppressive tumor microenvironment compromises the therapeutic efficiency of this technique. To ove

Externí odkaz: https://doaj.org/article/c9635a2b6b9745a5bbbbcf516692ae29

ROS-Responsive Nanoparticle as a Berberine Carrier for OHC-Targeted Therapy of Noise-Induced Hearing Loss

Autor: Yalan Li, Wei Zhuang, Konduru Naveena, Xi Shi, Ting Li, Xuanyi Li, Shiwei Qiu, Yuehua Qiao, Zhengzhong Han, Zeqi Zhao, Hongmei Liu, Guanxiong Lei

Publikováno v: ACS applied materialsinterfaces. 13(6)

Overproduction of reactive oxygen species (ROS) and inflammation are two key pathogeneses of noise-induced hearing loss (NIHL), which leads to outer hair cell (OHC) damage and hearing loss. In this work, we successfully developed ROS-responsive nanop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8ed7d9dbac5aa289a327a476d55c996
https://pubmed.ncbi.nlm.nih.gov/33528239

A method to induce human cortical long-term potentiation by acoustic stimulation

Autor: Yuehua Qiao, Yan Yan, Zeqi Zhao, Keshuang Wang, Shiming Yang, Xiaoyan Ma, Liming Yu, Yalan Li, Guanxiong Lei, Xin Zhang, Weidong Shen, Duo Zhang, Qian Wang

Publikováno v: Acta Oto-Laryngologica. 137:1069-1076

Acoustic stimulation induced LTP in the human auditory cortex was successfully recorded for the first time by electroencephalography (EEG) using a stimulus of 1 kHz pure-tone in 2005. However, it was barely reproduced, given considerable challenges t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a1fb3717be1112e4d793bd2b52e0a2a
https://doi.org/10.1080/00016489.2017.1332428

Differences in cerebral structure among patients with amnestic mild cognitive impairment and patients with Alzheimer's disease.

Autor: Cui, Xiaorui, Li, Mingpeng, Lei, Guanxiong, Wang, Jie, Pan, Jialin, Zhu, Sheng, Wu, Tao, Zou, Liangyu, Yan, Jianhui

Publikováno v: Frontiers in Aging Neuroscience; 2024, p1-8, 8p

Cas12f1 gene drives propagate efficiently in herpesviruses and induce minimal resistance.

Autor: Lin Z; Department of Immunology, School of Basic Medicine, Southern Medical University, Guangzhou, Guangdong Province, China., Yao Q; Department of Immunology, School of Basic Medicine, Southern Medical University, Guangzhou, Guangdong Province, China., Lai K; Department of Immunology, School of Basic Medicine, Southern Medical University, Guangzhou, Guangdong Province, China., Jiao K; Department of Geriatric Medicine, Shanghai Health and Medical Center, Wuxi, Jiangshu Province, China., Zeng X; Department of Immunology, School of Basic Medicine, Southern Medical University, Guangzhou, Guangdong Province, China., Lei G; Affiliated Hospital of Xiangnan University, Chenzhou, Hunan Province, China.; Key Laboratory of Medical Imaging and Artificial Intelligence of Hunan Province, Chenzhou, Hunan Province, China., Zhang T; Department of Immunology, School of Basic Medicine, Southern Medical University, Guangzhou, Guangdong Province, China. vaccine-sz@outlook.com.; Vaccine Biotech (Shenzhen) LTD, Shenzhen, China, & Boji Biopharmaceutical, Guangzhou, China. vaccine-sz@outlook.com., Dai H; Department of Immunology, School of Basic Medicine, Southern Medical University, Guangzhou, Guangdong Province, China. daihsh@outlook.com.

Publikováno v: Genome biology [Genome Biol] 2024 Dec 18; Vol. 25 (1), pp. 311. Date of Electronic Publication: 2024 Dec 18.