Výsledky vyhledávání - "Guanjun Cheng"

Akademický článek

3,3′-Diindolylmethane enhances apoptosis in docetaxel-treated breast cancer cells by generation of reactive oxygen species

Autor: Susan Lanza-Jacoby, Guanjun Cheng

Publikováno v: Pharmaceutical Biology, Vol 56, Iss 1, Pp 407-414 (2018)

Context: A major problem in the treatment of cancer is the development of toxic side effects and resistance to chemotherapy. The use of plant compounds to overcome resistance and prevent toxicity is a potential strategy for treatment. Objective: We e

Externí odkaz: https://doaj.org/article/63abb313b5e54aadbcb7e615033e1b9b

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Akademický článek

Tumor Necrosis Factor α Increases Neuronal Vulnerability to Excitotoxic Necrosis by Inducing Expression of the AMPA–Glutamate Receptor Subunit GluR1 via an Acid Sphingomyelinase- and NF-κB-Dependent Mechanism

Autor: ZaiFang Yu, Guanjun Cheng, Xiaoming Wen, Gary D. Wu, Wang-Tso Lee, David Pleasure

Publikováno v: Neurobiology of Disease, Vol 11, Iss 1, Pp 199-213 (2002)

Acid sphingomyelinase (ASMase) and NF-κB participate in tumor necrosis factor α (TNFα) signal transduction. Mice in which the genes encoding ASMase or the p50 subunit of NF-κB are disrupted have been reported to be less vulnerable than wild-type

Externí odkaz: https://doaj.org/article/2f6ede74064f466f849ab9db1ab61c02

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Akademický článek

Transcriptomic analysis comparing tumor-associated neutrophils with granulocytic myeloid-derived suppressor cells and normal neutrophils.

Autor: Zvi G Fridlender, Jing Sun, Inbal Mishalian, Sunil Singhal, Guanjun Cheng, Veena Kapoor, Wenhwai Horng, Gil Fridlender, Rachel Bayuh, G Scott Worthen, Steven M Albelda

Publikováno v: PLoS ONE, Vol 7, Iss 2, p e31524 (2012)

The role of myeloid cells in supporting cancer growth is well established. Most work has focused on myeloid-derived suppressor cells (MDSC) that accumulate in tumor-bearing animals, but tumor-associated neutrophils (TAN) are also known to be capable

Externí odkaz: https://doaj.org/article/1d5b9beda32c4d08a69d31ac68392541

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Data from CCL2 Blockade Augments Cancer Immunotherapy

Autor: Steven M. Albelda, Linda A. Snyder, Daniel Heitjan, Liang-Chuan S. Wang, M. Cecilia Crisanti, Sunil Singhal, Jing Sun, Guanjun Cheng, Veena Kapoor, George Buchlis, Zvi G. Fridlender

Altering the immunosuppressive microenvironment that exists within a tumor will likely be necessary for cancer vaccines to trigger an effective antitumor response. Monocyte chemoattractant proteins (such as CCL2) are produced by many tumors and have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b7d86ae4e7e6dca427fffee9a7f8deaf
https://doi.org/10.1158/0008-5472.c.6500100.v1

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Data from Systemic Blockade of Transforming Growth Factor-β Signaling Augments the Efficacy of Immunogene Therapy

Autor: Steven M. Albelda, Leona Ling, Larry R. Kaiser, Michael Corbley, Xiamei Zhang, Hung Kam Cheung, Andrew Haas, Guanjun Cheng, Veena Kapoor, Jing Sun, Zvi G. Fridlender, George Buchlis, Samuel Kim

Locally produced transforming growth factor-β (TGF-β) promotes tumor-induced immunosuppression and contributes to resistance to immunotherapy. This article explores the potential for increased efficacy when combining immunotherapies with TGF-β sup

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d41750078a79ff23a176960b72aced
https://doi.org/10.1158/0008-5472.c.6498182.v1

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