Výsledky vyhledávání - "Guanidines/*pharmacology"

Nafamostat reduces systemic inflammation in TLR7-mediated virus-like illness

Autor: Abi G. Yates, Caroline M. Weglinski, Yuxin Ying, Isobel K. Dunstan, Tatyana Strekalova, Daniel C. Anthony

Publikováno v: Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-16 (2022)
Yates, A G, Weglinski, C M, Ying, Y, Dunstan, I K, Strekalova, T & Anthony, D C 2022, ' Nafamostat reduces systemic inflammation in TLR7-mediated virus-like illness ', Journal of Neuroinflammation, vol. 19, 8 . https://doi.org/10.1186/s12974-021-02357-y
Journal of Neuroinflammation

Background The serine protease inhibitor nafamostat has been proposed as a treatment for COVID-19, by inhibiting TMPRSS2-mediated viral cell entry. Nafamostat has been shown to have other, immunomodulatory effects, which may be beneficial for treatme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ff4d7186f1eedb509337a7370816993
https://doi.org/10.1186/s12974-021-02357-y

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Upregulated Na+/H+-exchange protects human colon cancer tissue against intracellular acidification

Autor: Henrik Kold-Petersen, Ninna C. S. Voss, Casper Homilius, Ebbe Boedtkjer, Mikkel B. Henningsen

Publikováno v: Voss, N C S, Kold-Petersen, H H, Henningsen, M B, Homilius, C & Boedtkjer, E 2019, ' Upregulated Na + /H +-exchange protects human colon cancer tissue against intracellular acidification ', BioMed Research International, vol. 2019, 3702783 . https://doi.org/10.1155/2019/3702783
BioMed Research International
BioMed Research International, Vol 2019 (2019)

Increased metabolism accelerates local acid production in cancer tissue. The mechanisms eliminating acidic waste products from human colon cancer tissue represent promising therapeutic targets for pharmacological manipulation in order to improve prog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::100bf714c00d6aa3a98379d7784224cf
https://pure.au.dk/portal/da/publications/upregulated-nahexchange-protects-human-colon-cancer-tissue-against-intracellular-acidification(08df03a6-f0bc-4f85-9e91-5d4daf27a06f).html

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Heteroarylguanidines as Allosteric Modulators of ASIC1a and ASIC3 Channels

Autor: Hassan Hammoud, Stephan Kellenberger, Martine Schmitt, Maud Bollenbach, Omar Alijevic, Anand Vaithia, Viktor Trendafilov, Frédéric Bihel

Publikováno v: ACS chemical neuroscience, vol. 9, no. 6, pp. 1357-1365
ACS Chemical Neuroscience
ACS Chemical Neuroscience, American Chemical Society (ACS), 2018, 9 (6), pp.1357-1365. ⟨10.1021/acschemneuro.7b00529⟩

Acid-sensing ion channels (ASICs) are neuronal Na + -selective ion channels that open in response to extracellular acidification. They are involved in pain, fear, learning, and neurodegeneration after ischemic stroke. 2-Guanidine-4-methylquinazoline

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d27ac6b5a6c2d80e0d59d4affca0448c
https://serval.unil.ch/notice/serval:BIB_11B0CE680BFE

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Agonist actions of clothianidin on synaptic and extrasynaptic nicotinic acetylcholine receptors expressed on cockroach sixth abdominal ganglion

Autor: Steeve H. Thany

Publikováno v: Neurotoxicology
Neurotoxicology, 2009, 30 (6), pp.1045-1052. ⟨10.1016/j.neuro.2009.06.013⟩

International audience; Clothianidin is new neonicotinoid insecticide acting selectively on insect nicotinic acetylcholine receptors (nAChRs). Its effects on nAChRs expressed on cercal afferent/giant interneuron synapses and DUM neurons have been stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b33b4b0a8479351ce6e179970d5456c
https://doi.org/10.1016/j.neuro.2009.06.013

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Amiloride derivatives induce apoptosis by depleting ER Ca(2+) stores in vascular endothelial cells

Autor: Park, KS, Poburko, D, Wollheim, CB, Demaurex, N

Publikováno v: British Journal of Pharmacology, Vol. 156, No 8 (2009) pp. 1296-1304

BACKGROUND AND PURPOSE: Amiloride derivatives are blockers of the Na(+)/H(+) exchanger (NHE) and at micromolar concentrations have protective effects on cardiac and brain ischaemia/reperfusion injury but at higher concentrations also induce apoptosis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::eda0cf26c0e45c533b0172dbe17fb0ad
https://archive-ouverte.unige.ch/unige:20019

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Sensitivity of influenza viruses to zanamivir and oseltamivir: a study performed on viruses circulating in France prior to the introduction of neuraminidase inhibitors in clinical practice

Autor: Olivier Ferraris, Nicole Kessler, Bruno Lina

Publikováno v: Antiviral research. 68(1)

Influenza virus neuraminidase inhibitors (NAIs) were introduced in clinical practice in various parts of the world since 1999 but were only scarcely distributed in France. Prior to the generalization of zanamivir and oseltamivir utilization in our co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01d8c9c75800232dc9df8089475f2dc8
https://pubmed.ncbi.nlm.nih.gov/16125799

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Beneficial effects of aminoguanidine on peritoneal microcirculation and tissue remodelling in a rat model of PD

Autor: Geert-Jan Tangelder, Eelco D. Keuning, Liesbeth H. P. Hekking, Robert H.J. Beelen, Piet M. ter Wee, Mohammad Zareie, Casper G. Schalkwijk, Anton A van Lambalgen, Jacob van den Born, Inge L. Schadee-Eestermans

Publikováno v: Nephrology, Dialysis, Transplantation, 20(12), 2783-2792. Oxford University Press
Zareie, M, Tangelder, G J, ter Wee, P M, Hekking, LH, van Lambalgen, A A, Keuning, ED, Schadee-Eestermans, I L, Schalkwijk, C G, Beelen, R H J & van den Born, J 2005, ' Beneficial effects of aminoguanidine on peritoneal microcirculation and tissue remodelling in a rat model of PD ', Nephrology, Dialysis, Transplantation, vol. 20, no. 12, pp. 2783-2792 . https://doi.org/10.1093/ndt/gfi138

BACKGROUND: The formation of glucose degradation products (GDPs) and accumulation of advanced glycation end products (AGEs) partly contribute to the bioincompatibility of peritoneal dialysis fluids (PDF). Aminoguanidine (AG) scavenges GDPs and preven

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d1545d0840d8987b4d010442533255
https://research.vumc.nl/en/publications/3496f3e4-133c-44cf-ac2f-7ad60dd95311

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Heparan sulfate proteoglycan from human tubular basement membrane. Comparison with this component from the glomerular basement membrane

Autor: Jhm Berden, J.H. Veerkamp, L.P.W.J. van den Heuvel, T.J.A.M. van de Velden, C. H. Schröder, L. Schenkels, J. van den Born, L.A.H. Monnens

Publikováno v: Biochimica et biophysica acta, 1025(1), 67-76

Heparan sulfate proteoglycan (HSPG) was extracted from human tubular basement membrane (TBM) with guanidine and purified by ion-exchange chromatography and gel filtration. The glycoconjugate was sensitive to heparitinase and resistant to chondroitina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4b4e7f99a07ca0eb7db919cad532a36
https://research.rug.nl/en/publications/d63513e1-67e2-4988-b040-411a3aaf5b73

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Effets de deux inhibiteurs de la biosynthèse des polyamines sur la différenciation primaire de l'oeuf de Souris

Autor: Alexandre, Henri

Publikováno v: Comptes rendus hebdomadaires des séances de l'Académie des sciences. Série D, Sciences naturelles, 286 (16

Alpha-Methylornithine, an inhibitor of the synthesis of putrescine does not affect the cleavage of Mouse eggs, cultured in vitro from the 2-cell stage, before blastocyst formation, whereas methylglyoxal-Bis (guanylhydrazone), an inhibitor of the synt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2101::659747cdcb3a248e0155f12c211edee1
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/221152

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