Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Guangyi Liang"'
Autor:
Yi Liu, Jianguo Zhu, Zhanxing Hu, Yongqiang Zhang, Xinghui Wang, Xiaoping Zeng, Heng Luo, Zhonghang Wen, Bixue Xu, Guangyi Liang, Yuxin Xie
Publikováno v:
European Journal of Medicinal Chemistry. 133:227-239
A double Claisen rearrangements synthetic strategy was established for the total synthesis of 4,4′-dimethyl medicagenin (compound 6c). A series of its analogs also were prepared, including two novel 3′,5′-diprenylated chalcones, in which ring B
Publikováno v:
Tetrahedron Letters. 58:401-404
Three new diterpenoids, vulgarisins B–D (1–3), have been isolated from a medicinal plant Prunella vulgaris Linn. These diterpenoids contain a rare 5/6/4/5 fused tetracyclic ring skeleton. Their structures were determined through the analysis of s
Publikováno v:
Chinese Journal of Chemistry. 34:1353-1359
Matijin-Su (1) is a phenylalanine dipeptide compound with anti-hepatitis B virus (HBV) activity. Previous reports suggest that the synthesis of glycosylated Matijin-Su derivatives needs at least 10 steps. To simplify the synthetic procedure, we have
Autor:
Changxiao Liu, Weidong Pan, Qineng Gong, Jingying Qiu, Guangyi Liang, Zhengming Huang, Bixue Xu, Xiaoke Gu
Publikováno v:
Chemistry & Biodiversity. 13:1584-1592
A series of Matijin-Su (MTS, (2S)-2-{[(2S)-2-benzamido-3-phenylpropanoyl]amino}-3-phenylpropyl acetate) derivatives were synthesized and evaluated for their anti-HBV and cytotoxic activities in vitro. Six compounds (4g, 4j, 5c, 5g, 5h and 5i) showed
Autor:
Xiao-Pan Ma, Ping Yi, Hua-Yong Lou, Junjie Lan, Hong-guo Wu, Yong-Hua Tan, Guangyi Liang, Weidong Pan
Publikováno v:
Helvetica Chimica Acta. 99:302-305
Two new flavonoids, 1 and 2, together with two known flavonoids, tephrosin (3) and 12a-hydroxy-α-toxicarol (4), were isolated from the whole herb of Derris eriocarpa How. The structures and absolute configurations of the new compounds were elucidate
Autor:
Changxiao Liu, Shiqi Dong, Min Gong, Ya-zhuo Li, Guangyi Liang, Yu-li Wang, Fan-cui Meng, Huirong Fan
Publikováno v:
Chinese Herbal Medicines. 8:139-142
Objective To study the effect of bentysrepinine (Y101) metabolites on improving binding affinity of HBV DNA polymerase. Methods The binding mode of Y101 and its metabolites with DNA polymerase has been driven by hydrophobic interaction. Results Two c
Autor:
Dongbo Yuan, Heng Luo, Ke Wan, Jianguo Zhu, Zhonghang Wen, Xiaoping Zeng, Yongqiang Zhang, Bixue Xu, Guangyi Liang
Publikováno v:
Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 106
Leukemia is a hematologic malignancy with poor prognosis in humans and chemotherapy is the main strategy for treating leukemia patients. Novel drugs with better selectivity and lower toxicity are required for the treatment of patients. A novel 3',5'-
Autor:
Feng-Yun Jin, Hong-Mei Wu, Jing Feng, Weidong Pan, Xiang-Pei Wang, Hua-Yong Lou, Guangyi Liang, Ping Yi, Xiao-Pan Ma, Sai Jiang, Yu Zhang
Publikováno v:
Chinese journal of natural medicines. 16(8)
In the present study, four new sesquiterpenoids, chimonols A-D (compounds 1-4), together with four known compounds (5-8) were isolated from the EtOAc extract of Chimonanthus praecox Link. The structures of these new compounds were elucidated on the b
Publikováno v:
Journal of Carbohydrate Chemistry. 34:358-364
A new C21 steroidal glycoside, qinyangshengenin-3-O-β-D-digitoxopyranoside (1), together with a known steroidal glycoside, qinyangshengenin-3-O-β-D-oleandropyranosyl-(1→4)-β-D- cymaropyranosyl-(1→4...
Process development of clinical anti-HBV drug Y101: identification and synthesis of novel impurities
Autor:
Guangyi Liang, Changxiao Liu, Bixue Xu, Peixue Cao, Zhengming Huang, Weidong Pan, An Qiao, HaiJian Liao, Wen Xia, Zhanxing Hu
Publikováno v:
Research on Chemical Intermediates. 42:2577-2595
Nine novel process impurities of N-[N-benzoyl-O-(2-dimethylaminoethyl)-l-tyrosyl]-l-phenylalaninol (Y101) observed during the laboratory optimization and later during its bulk synthesis are described in this article. The impurities were monitored by