Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Guangya Xiang"'
Autor:
Xiaoguang Liu, Lixing Chen, Yuying Li, Chuanchuan He, Xiaojuan Zhang, Huimin Zhou, Guangfa Bao, Xiaohua Zhu, Guangya Xiang, Xiang Ma
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 165, Iss , Pp 115114- (2023)
Bifunctional chelators (BFCs), which link metallic radionuclide and a targeting vector, are some of the most crucial components of metallic radionuclide-based radiopharmaceuticals for positron-emission computed tomography (PET) imaging. In this study
Externí odkaz:
https://doaj.org/article/a7d339dcd1464307b373f573563fcc22
Publikováno v:
Journal of Nanobiotechnology, Vol 20, Iss 1, Pp 1-10 (2022)
Abstract Glioblastoma (GBM) is the most aggressive brain tumor, which owns the characteristics of high recurrence, low survival rate and poor prognosis because of the existence of blood brain barrier (BBB) and complicated brain tumor microenvironment
Externí odkaz:
https://doaj.org/article/2864a33e2a054126a1f9d08f0a75df9e
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1196-1211 (2022)
A new class of EGFR PROTACs based on pomalidomide was developed, synthesised, and tested for their cytotoxic activity against a panel of human cancer cells. Compounds 15–21 were showed to be more effective against the four tested cell lines than er
Externí odkaz:
https://doaj.org/article/1c3f97a53c4346b0a6eb670ff23cc4e2
Autor:
Xiaojuan Zhang, Chuanchuan He, Yun Sun, Xiaoguang Liu, Yan Chen, Chen Chen, Ruicong Yan, Ting Fan, Tan Yang, Yao Lu, Jun Luo, Xiang Ma, Guangya Xiang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 11, Pp 3608-3621 (2021)
Drug transportation is impeded by various barriers in the hypoxic solid tumor, resulting in compromised anticancer efficacy. Herein, a solid lipid monostearin (MS)-coated CaO2/MnO2 nanocarrier was designed to optimize doxorubicin (DOX) transportation
Externí odkaz:
https://doaj.org/article/6ba987ace84c45338883a028a6da140e
Autor:
Yan Chen, Lei Fang, Weixin Zhou, Jinghan Chang, Xiaojuan Zhang, Chuanchuan He, Chen Chen, Ruicong Yan, Yakai Yan, Yao Lu, Chuanrui Xu, Guangya Xiang
Publikováno v:
Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-20 (2021)
Abstract Background Hypoxic tumor microenvironment (TME) promotes tumor metastasis and drug resistance, leading to low efficiency of cancer chemotherapy. The development of targeted agents or multi-target therapies regulating hypoxic microenvironment
Externí odkaz:
https://doaj.org/article/f82226a034174a6b9e72b43e3d0ea661
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 9, Pp 1589-1600 (2020)
Antibody drug conjugates (ADCs) normally compose of a humanized antibody and small molecular drug via a chemical linker. After decades of preclinical and clinical studies, a series of ADCs have been widely used for treating specific tumor types in th
Externí odkaz:
https://doaj.org/article/eb045b7f8a54444aa85851359421c9db
Autor:
Pengxuan Zhao, Xucheng Hou, Jingyue Yan, Shi Du, Yonger Xue, Wenqing Li, Guangya Xiang, Yizhou Dong
Publikováno v:
Bioactive Materials, Vol 5, Iss 2, Pp 358-363 (2020)
Lipid-like nanoparticles (LLNs) have been extensively explored for messenger RNA (mRNA) delivery in various biomedical applications. However, the long-term storage of these nanoparticles is still a challenge for their clinical translation. In this st
Externí odkaz:
https://doaj.org/article/28560ab836ea444eae9133a67fb4223e
Autor:
Yan Chen, Chen Chen, Xiaojuan Zhang, Chuanchuan He, Pengxuan Zhao, Minsi Li, Ting Fan, Ruicong Yan, Yao Lu, Robert J. Lee, Muhammad Waseem Khan, Muhammad Sarfraz, Xiang Ma, Tan Yang, Guangya Xiang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 6, Pp 1106-1121 (2020)
Platinum-based chemotherapy is used for non-small cell lung cancer (NSCLC). However, it has side effects and minimum efficacy against lung cancer metastasis. In this study, platinum–curcumin complexes were loaded into pH and redox dual-responsive n
Externí odkaz:
https://doaj.org/article/b1b77bab49b84715a13e84ca6127e526
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 401 (2023)
The application of many currently evaluated macromolecular contrast agents for magnetic resonance imaging (MRI) has been limited because of their bio-incompatibility and toxicity. The aim of this study is to synthesize and characterize a new micelle-
Externí odkaz:
https://doaj.org/article/cbc036cf84944f2fb245185dc60ec18c
Autor:
Weijie Li, Ruicong Yan, Yong Liu, Chuanchuan He, Xiaojuan Zhang, Yao Lu, Muhammad Waseem Khan, Chuanrui Xu, Tan Yang, Guangya Xiang
Publikováno v:
Drug Delivery, Vol 26, Iss 1, Pp 794-802 (2019)
Overexpression of Bmi1 gene is an important feature of cancer stem cell in various human tumors. Therefore, Bmi1 gene can be a potential target for small interfering RNA (siRNA) mediated cancer therapy. Ursolic acid (UA) as a natural product plays a
Externí odkaz:
https://doaj.org/article/b62ad89b08cc4d9899c8e005b554202c