Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Guangxue Xu"'
Publikováno v:
PLoS Pathogens, Vol 20, Iss 2, p e1011953 (2024)
Carbonic anhydrase IV (Car4) is a newly identified receptor that allows adeno-associated virus (AAV) 9P31 to cross the blood-brain barrier and achieve efficient infection in the central nervous system (CNS) in mouse models. However, the molecular mec
Externí odkaz:
https://doaj.org/article/c14f3fbe4c394ede90ec4124acb82a18
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 52-60 (2022)
Clade F adeno-associated virus (AAV) 9 has been utilized as therapeutic gene delivery vector, and it is capable of crossing blood brain barrier (BBB). Recently, an AAV9-based engineering serotype AAVPHP.eB with enhanced BBB crossing ability further e
Externí odkaz:
https://doaj.org/article/47189b62d0a4410394f86bee49feaefe
Autor:
Nawal Al Kaabi, Yunkai Yang, Salah Eldin Hussein, Tian Yang, Jehad Abdalla, Hui Wang, Zhiyong Lou, Chinese Center for Disease Control and Prevention, Agyad Bakkour, Afnan Arafat, China National Biotec Group Company Limited, Zhiwei Jiang, Ye Tian, National Engineering Technology Research Center for Combined Vaccines, Wuhan Institute of Biological Products Co., Ltd., Beijing Institute of Biological Products Company Limited, Peng Xiao, Walid Zaher, Islam Eltantawy, Chenlong Wang, Guangxue Xu, Yuntao Zhang, Xiaoming Yang
Publikováno v:
Vaccines, Vol 11, Iss 2, p 299 (2023)
Importance: The protective efficacy of COVID-19 vaccinations has declined over time such that booster doses are required. Objective: To evaluate the efficacy and adverse events of booster doses of two inactivated COVID-19 vaccines. Design: This is a
Externí odkaz:
https://doaj.org/article/422bc5e9857040f5abe6d2578825bc64
Autor:
Ran Zhang, Guangxue Xu, Lin Cao, Zixian Sun, Yong He, Mengtian Cui, Yuna Sun, Shentao Li, Huapeng Li, Lan Qin, Mingxu Hu, Zhengjia Yuan, Zipei Rao, Wei Ding, Zihe Rao, Zhiyong Lou
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Multiple adeno-associated viruses (AAV) use the same receptor (AAVR), but the binding mode is not clear. Here, the authors determine the structures of the AAV1-AAVR and AAV5-AAVR complexes, identify residues necessary for virus entry and compare the
Externí odkaz:
https://doaj.org/article/65392197bcba492bad7e082068fe56c1
Autor:
Yuntao Zhang, Wenjie Tan, Zhiyong Lou, Yuxiu Zhao, Jin Zhang, Hongyang Liang, Na Li, Xiujuan Zhu, Ling Ding, Baoying Huang, Weimin Zhou, Yancen Guo, Zhaona Yang, Yuling Qiao, Zhenyu He, Bo Ma, Yao He, Di Zhu, Zhanhui Wang, Zhen Chang, Xue Zhao, Wei Wang, Ying Xu, Huiqin Zhu, Xiaotong Zheng, Chenlong Wang, Guangxue Xu, Guizhen Wu, Hui Wang, Xiaoming Yang
Publikováno v:
Vaccines, Vol 10, Iss 7, p 1149 (2022)
In response to the fast-waning immune response and the great threat of the Omicron variant of concern (VOC) to the public, we report the pilot-scale production of an inactivated Omicron vaccine candidate that induces high levels of neutralizing antib
Externí odkaz:
https://doaj.org/article/2bf8f861e184439aa2795f24f8dadba9
Publikováno v:
Journal of Innovative Optical Health Sciences, Vol 9, Iss 1, Pp 1650001-1-1650001-7 (2016)
Ultraviolet blood irradiation has been used as a physical therapy to treat many nonspecific diseases in clinics; however, the underlying mechanisms remain largely unclear. Neutrophils, the first line of host defense, play a crucial role in a variety
Externí odkaz:
https://doaj.org/article/95da32ae102b4f01a215a864c62158b0
Autor:
Yong He, Shentao Li, Mengtian Cui, Lan Qin, Zhengjia Yuan, Wei Ding, Ran Zhang, Mingxu Hu, Zixian Sun, Zhiyong Lou, Guangxue Xu, Yuna Sun, Zihe Rao, Zipei Rao, Lin Cao, Huapeng Li
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications
Nature Communications
Adeno-associated virus (AAV) receptor (AAVR) is an essential receptor for the entry of multiple AAV serotypes with divergent rules; however, the mechanism remains unclear. Here, we determine the structures of the AAV1-AAVR and AAV5-AAVR complexes, re
Publikováno v:
Journal of the American Chemical Society. 141:6545-6552
Despite accelerating development of CRISPR technology, there remains high demand for further interrogation of its fundamental biology. This is particularly fascinating as new improved CRISPR tools were artificially engineered to harbor beneficial fea
Autor:
Wenbo Xu, Yunkai Yang, Yang Liu, Qian Wang, Yuntao Zhang, Yongli Yang, Lili Huang, Xuqin Yang, Guangxue Xu, Wei Wang, Yuxiu Zhao, Hui Wang, Wenjie Tan, Xiaoming Yang, Zhiyong Lou, Wangyang You, Peipei Liu, Miao Xu, Wei Zhang, Weijin Huang, Y. Wang, Wenling Wang, Bojian Luo, Guizhen Wu, Ling Ding, George F. Gao, Zhiqiang Xie, Huijuan Wang, Shengli Xia, Na Li, Wanshen Guo, Baoying Huang
Publikováno v:
The Lancet Infectious Diseases
The Lancet. Infectious Diseases
The Lancet. Infectious Diseases
Summary Background The ongoing COVID-19 pandemic warrants accelerated efforts to test vaccine candidates. We aimed to assess the safety and immunogenicity of an inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine candidat
Autor:
Guangxue Xu, Ruckenstein Eli
Publikováno v:
Solution and Surface Polymerization ISBN: 9780429027420
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a652f691c1262136cb641d019f62e7d
https://doi.org/10.1201/9780429027420-35
https://doi.org/10.1201/9780429027420-35