Zobrazeno 1 - 10
of 181
pro vyhledávání: '"Guangrong, Zheng"'
Causality between migraine and cardiovascular disease: a bidirectional Mendelian randomization study
Autor:
Xirui Duan, Xiaolan Du, Guangrong Zheng, Xinyan Zhou, Na Tan, Guochen Li, Bin Liu, Mei Zhu, Tengfei Ke, Chengde Liao
Publikováno v:
The Journal of Headache and Pain, Vol 25, Iss 1, Pp 1-12 (2024)
Abstract Background While growing evidence suggests a relationship between migraine and cardiovascular disease, the genetic evidence for a causal relationship between migraine and cardiovascular disease is still scarce. Investigating the causal assoc
Externí odkaz:
https://doaj.org/article/934f7cae5c80486bb9af5b4640212c09
Autor:
Haiyan Shan, Guangrong Zheng, Shasha Bao, Haiyan Yang, Ujen Duwal Shrestha, Guochen Li, Xirui Duan, Xiaolan Du, Tengfei Ke, Chengde Liao
Publikováno v:
Translational Oncology, Vol 49, Iss , Pp 102115- (2024)
Objective: To demonstrate the feasibility of using focused ultrasound to enhance delivery of PD-1 inhibitors in glioma rats and determine if such an approach increases treatment efficacy. Methods: C6 glioma in situ rat model was used in this study. T
Externí odkaz:
https://doaj.org/article/f7bba7c1e3a84a918137877645fd3b52
Autor:
Hui Chen, Artem Gridnev, Netanya Schlamowitz, Wanyi Hu, Kuntala Dey, Guangrong Zheng, Jyoti R. Misra
Publikováno v:
Heliyon, Vol 10, Iss 18, Pp e37829- (2024)
The transcription factors, TEAD1-4 together with their co-activator YAP/TAZ function as key downstream effectors of the Hippo pathway. Hyperactivation of TEAD-YAP/TAZ activity is observed in many human cancers. TEAD1-4 possess distinct physiological
Externí odkaz:
https://doaj.org/article/04f8c3a78de34b3d8febf7c018afff4d
Autor:
Digant Nayak, Dongwen Lv, Yaxia Yuan, Peiyi Zhang, Wanyi Hu, Anindita Nayak, Eliza A. Ruben, Zongyang Lv, Patrick Sung, Robert Hromas, Guangrong Zheng, Daohong Zhou, Shaun K. Olsen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Overexpression of BCL-xL and BCL-2 play key roles in tumorigenesis and cancer drug resistance. Advances in PROTAC technology facilitated recent development of the first BCL-xL/BCL-2 dual degrader, 753b, a VHL-based degrader with improved pot
Externí odkaz:
https://doaj.org/article/4bf39db45fce4580a5d76e6623bf229c
Autor:
Xirui Duan, Zhiqiang Ouyang, Shasha Bao, Lu Yang, Ailin Deng, Guangrong Zheng, Yu Zhu, Guochen Li, Jixiang Chu, Chengde Liao
Publikováno v:
BMC Pulmonary Medicine, Vol 23, Iss 1, Pp 1-11 (2023)
Abstract Objective To establish a preoperative model for the differential diagnosis of benign and malignant pulmonary nodules (PNs), and to evaluate the related factors of overdiagnosis of benign PNs at the time of imaging assessments. Materials and
Externí odkaz:
https://doaj.org/article/1387a05521d9435bbb2c064eb3f4d19e
Autor:
Sajid Khan, Lin Cao, Janet Wiegand, Peiyi Zhang, Maria Zajac-Kaye, Frederic J. Kaye, Guangrong Zheng, Daohong Zhou
Publikováno v:
Cells, Vol 13, Iss 6, p 528 (2024)
BCL-xL and BCL-2 are validated therapeutic targets in small-cell lung cancer (SCLC). Targeting these proteins with navitoclax (formerly ABT263, a dual BCL-xL/2 inhibitor) induces dose-limiting thrombocytopenia through on-target BCL-xL inhibition in p
Externí odkaz:
https://doaj.org/article/a29e79df61604c65a48287af106a045c
Autor:
Sajid Khan, Patrick Kellish, Nick Connis, Dinesh Thummuri, Janet Wiegand, Peiyi Zhang, Xuan Zhang, Vivekananda Budamagunta, Nan Hua, Yang Yang, Umasankar De, Lingtao Jin, Weizhou Zhang, Guangrong Zheng, Robert Hromas, Christine Hann, Maria Zajac-Kaye, Frederic J. Kaye, Daohong Zhou
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-10 (2023)
Abstract Small-cell lung cancer (SCLC) is an aggressive malignancy with limited therapeutic options. The dismal prognosis in SCLC is in part associated with an upregulation of BCL-2 family anti-apoptotic proteins, including BCL-XL and MCL-1. Unfortun
Externí odkaz:
https://doaj.org/article/35172677c9ab498385ddea2d7bbcff21
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
Persistent fifth aortic arch (PFAA) is an extremely rare congenital cardiovascular anomaly resulting from the failure of the fifth aortic arch to degenerate during embryonic development; it is often associated with various other cardiovascular anomal
Externí odkaz:
https://doaj.org/article/9e7da1e483ed40f8a25738cc684a13ee
Autor:
Xirui Duan, Zhiqiang Ouyang, Shasha Bao, Lu Yang, Ailin Deng, Guangrong Zheng, Yu Zhu, Guochen Li, Jixiang Chu, Chengde Liao
Publikováno v:
BMC Pulmonary Medicine, Vol 23, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/01d0a29c84a2434db3e204ba7cd44477
Autor:
Yannan Jia, Lina Han, Cassandra L. Ramage, Zhe Wang, Connie C. Weng, Lei Yang, Simona Colla, Helen Ma, Weiguo Zhang, Michael Andreeff, Naval Daver, Nitin Jain, Naveen Pemmaraju, Kapil Bhalla, Satu Mustjoki, Peiyi Zhang, Guangrong Zheng, Daohong Zhou, Qi Zhang, Marina Konopleva
Publikováno v:
Haematologica, Vol 108, Iss 10 (2023)
BCL-XL and BCL-2 are key anti-apoptotic proteins and validated cancer targets. 753B is a novel BCL-XL/BCL-2 proteolysis targeting chimera (PROTAC) that targets both BCL-XL and BCL-2 to the von Hippel-Lindau (VHL) E3 ligase, leading to BCLX L/BCL-2 ub
Externí odkaz:
https://doaj.org/article/44723b7d8a04476c9f09a39b30c15fb8