Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Guangqian Xing"'
Autor:
Hairong Shi, Hongshun Wang, Cheng Zhang, Yajie Lu, Jun Yao, Zhibin Chen, Guangqian Xing, Qinjun Wei, Xin Cao
Publikováno v:
JCI Insight, Vol 7, Iss 4 (2022)
Defective primary cilia cause a range of diseases called ciliopathies, which include hearing loss (HL). Variants in the human oxysterol-binding protein like 2 (OSBPL2/ORP2) are responsible for autosomal dominant nonsyndromic HL (DFNA67). However, the
Externí odkaz:
https://doaj.org/article/a76238c501cb4fcbb1d643656cd09ca0
Autor:
Tianming Wang, Qinjun Wei, Lihong Liang, Xujun Tang, Jun Yao, Yajie Lu, Yuan Qu, Zhibin Chen, Guangqian Xing, Xin Cao
Publikováno v:
iScience, Vol 23, Iss 7, Pp 101252- (2020)
Summary: The accumulation of giant lipid droplets (LDs) increases the risk of metabolic disorders including obesity and insulin resistance. The lipolysis process involves the activation and transfer of lipase, but the molecular mechanism is not compl
Externí odkaz:
https://doaj.org/article/498fd2ce4bed42138dc7de0ccb5c45bb
Publikováno v:
Case Reports in Medicine, Vol 2013 (2013)
Inflammatory pseudotumor (IP) is a clinically aggressive but histologically benign condition of unknown cause. Its appearance in the temporal bone is uncommon. We present clinical, radiological, and histopathologic findings of three cases originating
Externí odkaz:
https://doaj.org/article/043931c3ca0640708f54e3a4d957287c
Publikováno v:
Biochemical and biophysical research communications. 574
GPRASP2 is implicated in nervous system diseases, tumors and immune inflammation. In our previous study, G protein-coupled receptor associated sorting protein 2 (GPRASP2) was identified as a novel causal gene for X-linked recessive syndromic hearing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::970cd9602ef985a2cfe581f6813b01f7
https://pubmed.ncbi.nlm.nih.gov/34418635
https://pubmed.ncbi.nlm.nih.gov/34418635
Autor:
Changsong Lin, Quan Wang, Yajie Lu, Guangqian Xing, Hongshun Wang, Xin Cao, Qinjun Wei, Cui Zhang, Jun Yao
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 187:17-26
Oxysterol Binding Protein Like 2 (OSBPL2) is a lipid-binding protein implicated in various cellular processes. Previous studies have shown that depression of OSBPL2 significantly increases the level of cellular 25-hydroxycholesterol (25-OHC) which re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::754f917790856ae8d8945a0ef33c6461
https://doi.org/10.1016/j.jsbmb.2018.10.018
https://doi.org/10.1016/j.jsbmb.2018.10.018
Autor:
Yuan Qu, Xujun Tang, Yajie Lu, Tianming Wang, Jun Yao, Lihong Liang, Qinjun Wei, Xin Cao, Guangqian Xing, Zhibin Chen
Publikováno v:
iScience, Vol 23, Iss 7, Pp 101252-(2020)
iScience
iScience
Summary The accumulation of giant lipid droplets (LDs) increases the risk of metabolic disorders including obesity and insulin resistance. The lipolysis process involves the activation and transfer of lipase, but the molecular mechanism is not comple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af202afe3ec652e966fcd8a0ff5eac5e
http://www.sciencedirect.com/science/article/pii/S2589004220304387
http://www.sciencedirect.com/science/article/pii/S2589004220304387
Publikováno v:
Molecular Medicine Reports
G protein-coupled receptor-associated sorting protein 2 (GPRASP2), a member of the GASP family, has been reported to be involved in the modulation of transcription. However, few studies have revealed the role of GPRASP2 in the development and progres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7acf61c22cd615513e1a45166bf54003
https://doi.org/10.3892/mmr.2017.7357
https://doi.org/10.3892/mmr.2017.7357
Publikováno v:
Journal of Medical Genetics
BackgroundA substantial amount of nuclear genes have been identified to be implicated in genetic hearing loss, while X-linked hearing loss is genetically heterogeneous and relatively infrequent.ObjectiveTo identify the causative gene mutation in a fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec7abad5094970b910407934364e3fbd
http://europepmc.org/articles/PMC5502311
http://europepmc.org/articles/PMC5502311
Autor:
Yajie Lu, Guangqian Xing, Jun Yao, Zhibin Chen, Qinjun Wei, Xin Cao, Changsong Lin, Cui Zhang, Hairong Shi, Hongshun Wang
Publikováno v:
Cell Death and Disease, Vol 10, Iss 9, Pp 1-13 (2019)
Cell Death & Disease
Cell Death & Disease
Oxysterol-binding protein like 2 (OSBPL2) was identified as a novel causal gene for autosomal dominant nonsyndromic hearing loss. However, the pathogenesis of OSBPL2 deficits in ADNSHL was still unclear. The function of OSBPL2 as a lipid-sensing regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7b319c189ac6de6cda3c3774a440d99
https://doi.org/10.1038/s41419-019-1858-9
https://doi.org/10.1038/s41419-019-1858-9
Autor:
Guangqian Xing, Yajie Lu, Xin Cao, Zhibin Chen, Qiang Xiong, Jun Yao, Haiyuan Yang, Qinjun Wei, Lining Zhang, Min Zhang, Yifan Dai, Huasha Zeng, Ying Wang, Rongfeng Li
Publikováno v:
Journal of genetics and genomics = Yi chuan xue bao. 46(8)
Oxysterol binding protein like 2 (OSBPL2), an important regulator in cellular lipid metabolism and transport, was identified as a novel deafness-causal gene in our previous work. To resemble the phenotypic features of OSBPL2 mutation in animal models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e63905362682f9970dcd28a727dcaf3
https://pubmed.ncbi.nlm.nih.gov/31451425
https://pubmed.ncbi.nlm.nih.gov/31451425