Efficient pH-Responsive Nano-Drug Delivery System Based on Dynamic Boronic Acid/Ester Transformation

Autor: Weijun Chen, Wanxuan Xie, Guangkuo Zhao, Qi Shuai

Publikováno v: Molecules, Vol 28, Iss 11, p 4461 (2023)

Chemotherapy is currently one of the most widely used treatments for cancer. However, traditional chemotherapy drugs normally have poor tumor selectivity, leading to insufficient accumulation at the tumor site and high systemic cytotoxicity. To addre

Externí odkaz: https://doaj.org/article/0634aa99a56f4aeda6e3343fdd63849f

Improved paclitaxel delivery with PEG-b-PLA/zein nanoparticles prepared via flash nanoprecipitation

Autor: Wenbo, Ye, Fangtao, Zhu, Yue, Cai, Longyu, Wang, Guangliang, Zhang, Guangkuo, Zhao, Xiaohe, Chu, Qi, Shuai, Yunfeng, Yan

Publikováno v: International Journal of Biological Macromolecules. 221:486-495

Polymeric micelle is a promising vehicle to improve the bioavailability and clinical outcomes of paclitaxel (PTX) which has been proven effective in the treatment of a wide range of cancers. However, conventional PTX formulation with the amphiphilic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c41981888f798d6bed7b2bfb51e442d
https://doi.org/10.1016/j.ijbiomac.2022.09.021

Highly Efficient Modular Construction of Functional Drug Delivery Platform Based on Amphiphilic Biodegradable Polymers via Click Chemistry

Autor: Qi Shuai, Yunfeng Yan, Tongtong Ge, Guangkuo Zhao, Weike Su

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 10407, p 10407 (2021)
Volume 22
Issue 19

Amphiphilic copolymers with pendant functional groups in polyester segments are widely used in nanomedicine. These enriched functionalities are designed to form covalent conjugates with payloads or provide additional stabilization effects for encapsu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a510b7363b1e41b23843b3c6626b8a80
https://pubmed.ncbi.nlm.nih.gov/34638747

Cell-Penetrating Peptide Modified PEG-PLA Micelles for Efficient PTX Delivery

Autor: Guangkuo Zhao, Xuanrong Sun, Yue Cai, Qi Shuai

Publikováno v: International Journal of Molecular Sciences
Volume 21
Issue 5
International Journal of Molecular Sciences, Vol 21, Iss 5, p 1856 (2020)

On account of their excellent capacity to significantly improve the bioavailability and solubility of chemotherapy drugs, amphiphilic block copolymer-based micelles have been widely utilized for chemotherapy drug delivery. In order to further improve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::babf92dc40ede6a6fc6f29f1e2db0c53
http://europepmc.org/articles/PMC7084196

Self-assembling poly(ethylene glycol)-block-polylactide-cabazitaxel conjugate nanoparticles for anticancer therapy with high efficacy and low in vivo toxicity

Autor: Wei Zhang, Guangkuo Zhao, Jianqin Wan, Hangxiang Wang, Weike Su, Xuefan Lian, Beini Cen, Jialin Liu, Qi Shuai

Publikováno v: International Journal of Pharmaceutics. 574:118879

Traditional approaches used for transforming hydrophobic anticancer drugs into therapeutically available nanoparticles heavily rely on the noncovalent formulation of drugs within amphiphilic copolymers. However, these nanotherapies have not yet shown

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88609bb84e4f2a061b5b77b386d12ef6
https://doi.org/10.1016/j.ijpharm.2019.118879