Zobrazeno 1 - 10
of 236
pro vyhledávání: '"Guangju Zhai"'
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-8 (2024)
Abstract Background Genomic heterozygosity has been shown to confer a health advantage in humans and play a protective role in complex diseases. Given osteoarthritis (OA) is a highly polygenic disease, we set out to determine if an association exists
Externí odkaz:
https://doaj.org/article/ac8457d4e32848b7824fdaaaf8c9b23d
Publikováno v:
Metabolites, Vol 14, Iss 9, p 480 (2024)
(1) Background: Osteoarthritis (OA) is a heterogeneous disorder, and subgroup classification of OA remains elusive. The aim of our study was to identify endotypes of hip OA and investigate the altered pathways in the different endotypes. (2) Methods:
Externí odkaz:
https://doaj.org/article/ee51fe702b164f288dc8a0023f7f730e
Autor:
Ginette Tardif, Frédéric Paré, Clarisse Gotti, Florence Roux-Dalvai, Arnaud Droit, Guangju Zhai, Guang Sun, Hassan Fahmi, Jean-Pierre Pelletier, Johanne Martel-Pelletier
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-16 (2022)
Abstract Background Osteoarthritis (OA) is a slowly developing and debilitating disease, and there are no validated specific biomarkers for its early detection. To improve therapeutic approaches, identification of specific molecules/biomarkers enabli
Externí odkaz:
https://doaj.org/article/cedea55d8a3f4c18b61c342dfbb76726
Autor:
Salem Werdyani, Dawn Aitken, Zhiwei Gao, Ming Liu, Edward W. Randell, Proton Rahman, Graeme Jones, Guangju Zhai
Publikováno v:
Skeletal Muscle, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Background Skeletal muscles are essential components of the neuromuscular skeletal system that have an integral role in the structure and function of the synovial joints which are often affected by osteoarthritis (OA). The aim of this study
Externí odkaz:
https://doaj.org/article/44151bc8669a4d08ba72a3730c2f7256
Autor:
Ming Liu, Zikun Xie, Guang Sun, Liujun Chen, Dake Qi, Hongwei Zhang, Jieying Xiong, Andrew Furey, Proton Rahman, Guanghua Lei, Guangju Zhai
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-10 (2021)
Abstract Background Osteoarthritis (OA) is the most prevalent form of arthritis and the major cause of disability and overall diminution of quality of life in the elderly population. Currently there is no cure for OA, partly due to the large gaps in
Externí odkaz:
https://doaj.org/article/03f9749a3b5148ba81d7bfda8b6f534e
Autor:
Guangju Zhai, Jean-Pierre Pelletier, Ming Liu, Edward W. Randell, Proton Rahman, Johanne Martel-Pelletier
Publikováno v:
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-5 (2019)
Abstract Background Identification of the optimal treatment for a given patient is of paramount importance. This is of particular relevance in osteoarthritis (OA) because of the high prevalence of the disease, extensive heterogeneity of the disease,
Externí odkaz:
https://doaj.org/article/6a01d1413ebf4571ac003773d01d02f4
Autor:
Guangju Zhai
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 3, Iss 4, Pp 100170- (2021)
Objectives: A narrative review on recent published studies of metabolomics in osteoarthritis (OA) with the focus on how the metabolomic findings help stratify OA patients in precision medicine. Design: A narrative review based on selected population-
Externí odkaz:
https://doaj.org/article/e0e3e22ec8c24f01a40c1ede736d0f8b
Publikováno v:
Life, Vol 12, Iss 6, p 869 (2022)
Osteoarthritis (OA) is the most prevalent joint disorder characterized by joint structural pathological changes with the loss of articular cartilage as its hallmark. Tools that can predict cartilage loss would help identify people at high risk, thus
Externí odkaz:
https://doaj.org/article/ef180c4c1077450c9bf996780b48e27f
Autor:
Ming Liu, Yiheng Huang, Hongwei Zhang, Dawn Aitken, Michael C. Nevitt, Jason S. Rockel, Jean-Pierre Pelletier, Cora E. Lewis, James Torner, Yoga Raja Rampersaud, Anthony V. Perruccio, Nizar N. Mahomed, Andrew Furey, Edward W. Randell, Proton Rahman, Guang Sun, Johanne Martel-Pelletier, Mohit Kapoor, Graeme Jones, David Felson, Dake Qi, Guangju Zhai
Publikováno v:
Metabolites, Vol 12, Iss 4, p 334 (2022)
Obesity is a global pandemic, but there is yet no effective measure to control it. Recent metabolomics studies have identified a signature of altered amino acid profiles to be associated with obesity, but it is unclear whether these findings have act
Externí odkaz:
https://doaj.org/article/be8a85981d014df1aab4161b6a3b1d68
Autor:
Canchen Ma, Ming Liu, Jing Tian, Guangju Zhai, Flavia Cicuttini, Yvette L. Schooneveldt, Peter J. Meikle, Graeme Jones, Feng Pan
Publikováno v:
Metabolites, Vol 12, Iss 3, p 206 (2022)
Lipid mediators have been suggested to have a role in pain sensitivity and response; however, longitudinal data on lipid metabolites and persistent multisite musculoskeletal pain (MSMP) are lacking. This study was to identify lipid metabolic markers
Externí odkaz:
https://doaj.org/article/64490565551f4710bf6451ec2b6cbf80