Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Guangjian Fan"'
Lactylated Apolipoprotein C‐II Induces Immunotherapy Resistance by Promoting Extracellular Lipolysis
Autor:
Jian Chen, Deping Zhao, Yupeng Wang, Ming Liu, Yuan Zhang, Tingting Feng, Chao Xiao, Huan Song, Rui Miao, Li Xu, Hongwei Chen, Xiaoying Qiu, Yi Xu, Jingxuan Xu, Zelin Cui, Wei Wang, Yanchun Quan, Yifeng Zhu, Chen Huang, Song Guo Zheng, Jian‐yuan Zhao, Ting Zhu, Lianhui Sun, Guangjian Fan
Publikováno v:
Advanced Science, Vol 11, Iss 38, Pp n/a-n/a (2024)
Abstract Mortality rates due to lung cancer are high worldwide. Although PD‐1 and PD‐L1 immune checkpoint inhibitors boost the survival of patients with non‐small‐cell lung cancer (NSCLC), resistance often arises. The Warburg Effect, which ca
Externí odkaz:
https://doaj.org/article/88d173ca899746b58f577c26b1255723
Autor:
Lianhui Sun, Yuan Zhang, Boyu Yang, Sijun Sun, Pengshan Zhang, Zai Luo, Tingting Feng, Zelin Cui, Ting Zhu, Yuming Li, Zhengjun Qiu, Guangjian Fan, Chen Huang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Cuproptosis, caused by excessively high copper concentrations, is urgently exploited as a potential cancer therapeutic. However, the mechanisms underlying the initiation, propagation, and ultimate execution of cuproptosis in tumors remain un
Externí odkaz:
https://doaj.org/article/5db9a4a545be44c3b1fa6184874118e4
Autor:
Lianhui Sun, Xing Wang, Lixiao Chen, Zheng Gao, Songhui Xu, Chen Hu, Guangjian Fan, Baoxin Wang, Tingting Feng, Wang Wang, Xinjiang Ying
Publikováno v:
Cell Insight, Vol 2, Iss 6, Pp 100127- (2023)
Hypopharyngeal squamous cell carcinoma (HSCC) is a highly aggressive malignancy that constitutes approximately 95% of all hypopharyngeal carcinomas, and it carries a poor prognosis. The primary factor influencing the efficacy of anti-cancer drugs for
Externí odkaz:
https://doaj.org/article/5920ca4793a240f49c53a728285cb3db
Autor:
Guangjian Fan, Lianhui Sun, Ling Meng, Chen Hu, Xing Wang, Zhan Shi, Congli Hu, Yang Han, Qingqing Yang, Liu Cao, Xiaohong Zhang, Yan Zhang, Xianmin Song, Shujie Xia, Baokun He, Shengping Zhang, Chuangui Wang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Centrosome clustering is a promising therapeutic target in cancer but how it is regulated remains unclear. Here, the authors show that in response to DNA damage, ATM/ATR stabilize the centrosome clustering regulator KIFC1 leading to increased cluster
Externí odkaz:
https://doaj.org/article/3daed719cc8f4fb3a0c84168a894c7e5
Autor:
Lianhui Sun, Guangjian Fan, Peipei Shan, Xiaoying Qiu, Shuxian Dong, Lujian Liao, Chunlei Yu, Tingting Wang, Xiaoyang Gu, Qian Li, Xiaoyu Song, Liu Cao, Xiaotao Li, Yongping Cui, Shengping Zhang, Chuangui Wang
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
In conditions of energy stress cells reduce transcription of ribosomal RNA (rRNA) to maintain cell survival. Here, the authors show that energy stress induces an AMPK-dependent phosphorylation of Sirt7, which promotes its ubiquitin-independent degrad
Externí odkaz:
https://doaj.org/article/f5eff28dc2384939a26d207ce876a68f
Autor:
Xiaoqing Lu, Liwei An, Guangjian Fan, Lijuan Zang, Weiyi Huang, Junjian Li, Jun Liu, Weiyu Ge, Yuwei Huang, Jingxuan Xu, Shaoqian Du, Yuan Cao, Tianhao Zhou, Huijing Yin, Li Yu, Shi Jiao, Hongxia Wang
Publikováno v:
Cell Res
TSPAN family of proteins are generally considered to assemble as multimeric complexes on the plasma membrane. Our previous work uncovered that TSPAN8 can translocate into the nucleus as a membrane-free form, a process that requires TSPAN8 palmitoylat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a9d474e4ee2f75be81aaa31fa6bbc8
https://doi.org/10.1038/s41422-022-00628-8
https://doi.org/10.1038/s41422-022-00628-8
Autor:
Yuan Yuan, Guangjian Fan, Yuqi Liu, Lu Liu, Tong Zhang, Pengfei Liu, Qing Tu, Xinyi Zhang, Shiyuan Luo, Liangfang Yao, Feng Chen, Jingbao Li
Publikováno v:
Cell Mol Immunol
Sepsis is a heterogeneous syndrome induced by a dysregulated host response to infection. Glycolysis plays a role in maintaining the immune function of macrophages, which is crucial for severely septic patients. However, how the pathways that link gly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb8930c2e5b1bd3ee6c2b8ba299e74e3
https://doi.org/10.1038/s41423-021-00806-5
https://doi.org/10.1038/s41423-021-00806-5
During the 13th Five-Year Plan period (2016–2020), China has comprehensively strengthened the prevention and control of air pollution. The comprehensive treatment of air pollution has been fully implemented since 2016 and the ambient air quality in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::413e737dc0d2902aee54825054dd894f
https://doi.org/10.21203/rs.3.rs-2001296/v1
https://doi.org/10.21203/rs.3.rs-2001296/v1
Autor:
Mengyi Jiang, Hongxia Wang, Lijuan Zang, Liqun Zhu, Shaoqian Du, Tianhao Zhou, Junjian Li, Guangjian Fan, Zhenghong Lao, Yu Yue, Xiaoliang Chen, Yuan Cao, Xu Jingxuan, Weiyu Ge
Publikováno v:
Oncogene
Pancreatic ductal adenocarcinoma (PDAC) is the deadliest cancer mainly owing to its proclivity to early metastasis and the lack of effective targeted therapeutic drugs. Hence, understanding the molecular mechanisms underlying early invasion and metas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c462d9509f38bb66beb4086d36adc60
https://doi.org/10.1038/s41388-021-01864-9
https://doi.org/10.1038/s41388-021-01864-9
Publikováno v:
Microscopy research and techniqueREFERENCES. 85(11)
The pollution of lead (Pb (II)) to water resources is becoming more and more serious. It is always a difficult problem to find efficient and low-cost adsorbents. Chicken manure (CM) and Chinese medicine residue (CMR) were modified with potassium dihy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53eb7102c86bb737b19d192b66d0c599
https://pubmed.ncbi.nlm.nih.gov/35869784
https://pubmed.ncbi.nlm.nih.gov/35869784