Zobrazeno 1 - 10
of 234
pro vyhledávání: '"Guanghong Wei"'
Autor:
Vasantha Basavalingappa, Santu Bera, Bin Xue, Ido Azuri, Yiming Tang, Kai Tao, Linda J. W. Shimon, Michael R. Sawaya, Sofiya Kolusheva, David S. Eisenberg, Leeor Kronik, Yi Cao, Guanghong Wei, Ehud Gazit
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
DNA is an attractive nanomaterial, yet limited compared to polyamides due to low stability and mechanical issues. Here, the authors combine polyamide and DNA characteristics to form mechanically rigid self-assembled peptide nucleic acid based materia
Externí odkaz:
https://doaj.org/article/fe1796cb54ed4a099a3b5e137059ad29
Autor:
Yiming Tang, Santu Bera, Yifei Yao, Jiyuan Zeng, Zenghui Lao, Xuewei Dong, Ehud Gazit, Guanghong Wei
Publikováno v:
Cell Reports Physical Science, Vol 2, Iss 9, Pp 100579- (2021)
Summary: Liquid-liquid phase separation (LLPS) of proteins mediates the assembly of biomolecular condensates involved in physiological and pathological processes. Identifying the minimalistic building blocks and the sequence determinant of protein ph
Externí odkaz:
https://doaj.org/article/40dc9ef8c24d43758c49896e1bd06c60
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Protein aggregation, involving the formation of dimers, oligomers, and fibrils, is associated with many human diseases. Type 2 diabetes is one of the common amyloidosis and linked with the aggregation of human islet amyloid polypeptide (hIAPP). A ser
Externí odkaz:
https://doaj.org/article/63be39f1f8f141529d603ee9a04a6bf9
Autor:
Vasantha Basavalingappa, Tom Guterman, Yiming Tang, Sivan Nir, Jiangtao Lei, Priyadarshi Chakraborty, Lee Schnaider, Meital Reches, Guanghong Wei, Ehud Gazit
Publikováno v:
Advanced Science, Vol 6, Iss 12, Pp n/a-n/a (2019)
Abstract Peptidomimetic low‐molecular‐weight hydrogelators, a class of peptide‐like molecules with various backbone amide modifications, typically give rise to hydrogels of diverse properties and increased stability compared to peptide hydrogel
Externí odkaz:
https://doaj.org/article/81d89dcf59804ad1b1de25f5ed2be9fb
Autor:
Ying Li, Zhenyu Qian, Li Ma, Shuxin Hu, Daguan Nong, Chunhua Xu, Fangfu Ye, Ying Lu, Guanghong Wei, Ming Li
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Assessing protein localization within lipid membranes is problematic. Here, the authors describe a single molecule visualization method based on surface-induced fluorescence attenuation (SIFA) to determine the insertion depth and lateral diffusion of
Externí odkaz:
https://doaj.org/article/a28f4e82436648fabfc779dd0029fad1
Membrane Binding and Insertion of a pHLIP Peptide Studied by All-Atom Molecular Dynamics Simulations
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 7, Pp 14532-14549 (2013)
Recent experiments in function mechanism study reported that a pH low-insertion peptide (pHLIP) can insert into a zwitterionic palmitoyloleoylphosphatidylcholine (POPC) lipid bilayer at acidic pH while binding to the bilayer surface at basic pH. Howe
Externí odkaz:
https://doaj.org/article/befd15f9fdc244fcb475a821eb6fd39a
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 3, Pp 6241-6258 (2013)
Protein misfolding and aggregation cause serious degenerative diseases, such as Alzheimer’s and type II diabetes. Human islet amyloid polypeptide (hIAPP) is the major component of amyloid deposits found in the pancreas of type II diabetic patients.
Externí odkaz:
https://doaj.org/article/c874724288c842a99e7d2af4d35c24ed
Publikováno v:
Journal of Diabetes Research, Vol 2016 (2016)
Increasing evidence suggests that the interaction of human islet amyloid polypeptide (hIAPP) with lipids may facilitate hIAPP aggregation and cause the death of pancreatic islet β-cells. However, the detailed hIAPP-membrane interactions and the infl
Externí odkaz:
https://doaj.org/article/ab81a36579ee417c8b7a662ca15aef6c
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e38191 (2012)
The aggregation of human islet amyloid polypeptide (hIAPP or amylin) is associated with the pathogenesis of type 2 diabetes mellitus. Increasing evidence suggests that the interaction of hIAPP with β-cell membranes plays a crucial role in cytotoxici
Externí odkaz:
https://doaj.org/article/9907396f34c24bcc917f4e25be9ac5aa
Publikováno v:
Chemical Science; 8/28/2024, Vol. 15 Issue 32, p12806-12818, 13p