Zobrazeno 1 - 10
of 404
pro vyhledávání: '"Guangfu, Li"'
Autor:
Jiarui Feng, Haoran Song, Michael Province, Guangfu Li, Philip R. O. Payne, Yixin Chen, Fuhai Li
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Recently, large-scale scRNA-seq datasets have been generated to understand the complex signaling mechanisms within the microenvironment of Alzheimer’s Disease (AD), which are critical for identifying novel therapeutic targets and precision medicine
Externí odkaz:
https://doaj.org/article/d501505450194e8a8ab745654a7e2de7
Autor:
Ming Yang, Xiaoqiang Qi, Nan Li, Jussuf T. Kaifi, Shiyou Chen, Andrew A. Wheeler, Eric T. Kimchi, Aaron C. Ericsson, R. Scott Rector, Kevin F. Staveley-O’Carroll, Guangfu Li
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The interplay between western diet and gut microbiota drives the development of non-alcoholic fatty liver disease and its progression to non-alcoholic steatohepatitis. However, the specific microbial and metabolic mediators contributing to n
Externí odkaz:
https://doaj.org/article/b4b77dd13ef64968b1d1ab140e504033
Autor:
Kanve N. Suvilesh, Yulia I. Nussbaum, Vijay Radhakrishnan, Yariswamy Manjunath, Diego M. Avella, Kevin F. Staveley-O’Carroll, Eric T. Kimchi, Aadel A. Chaudhuri, Chi-Ren Shyu, Guangfu Li, Klaus Pantel, Wesley C. Warren, Jonathan B. Mitchem, Jussuf T. Kaifi
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-8 (2022)
Abstract Background Circulating tumor cells (CTCs) are liquid biopsies that represent micrometastatic disease and may offer unique insights into future recurrences in non-small cell lung cancer (NSCLC). Due to CTC rarity and limited stability, no sta
Externí odkaz:
https://doaj.org/article/a2df1dda5fd74b0dbf8798da022a3a42
Autor:
Mouadh Barbirou, Amanda Miller, Yariswamy Manjunath, Arturo B. Ramirez, Nolan G. Ericson, Kevin F. Staveley-O’Carroll, Jonathan B. Mitchem, Wesley C. Warren, Aadel A. Chaudhuri, Yi Huang, Guangfu Li, Peter J. Tonellato, Jussuf T. Kaifi
Publikováno v:
Current Issues in Molecular Biology, Vol 44, Iss 2, Pp 750-763 (2022)
Non-small-cell lung cancer (NSCLC) accounts for most cancer-related deaths worldwide. Liquid biopsy by a blood draw to detect circulating tumor cells (CTCs) is a tool for molecular profiling of cancer using single-cell and next-generation sequencing
Externí odkaz:
https://doaj.org/article/330aa8b920e541a482532e69ead1d49b
Autor:
Fengqin Xiao, Shuai Shao, Hongyin Zhang, Guangfu Li, Songlan Piao, Daqing Zhao, Guangzhe Li, Mingming Yan
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Ziziphus jujuba var. spinosa (Bunge) Hu ex H.F.Chow [Rhamnaceae; Ziziphi Spinosae Semen (ZSS)] has attracted extensive attention as the first choice of traditional Chinese medicine in the treatment of insomnia. However, recent studies on the sleep-im
Externí odkaz:
https://doaj.org/article/a852b5236521489d93b65f45fffced48
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Microfluidics have been applied to filtration of rare tumor cells from the blood as liquid biopsies. Processing is highly limited by low flow rates and device clogging due to a single function of fluidic paths. A novel method using multifunc
Externí odkaz:
https://doaj.org/article/17765ab8ef0a4ba5a09651028283e7a5
Publikováno v:
Biomedicines, Vol 11, Iss 5, p 1391 (2023)
Liver fibrosis accompanies the development of various chronic liver diseases and promotes their progression. It is characterized by the abnormal accumulation of extracellular matrix proteins (ECM) and impaired ECM degradation. Activated hepatic stell
Externí odkaz:
https://doaj.org/article/1ef0cf908b594be59c443cff8e1020fd
Autor:
Hao Liu, Yanli Liu, Zhen Zhao, Yuanke Li, Bahaa Mustafa, Zhijin Chen, Ashutosh Barve, Akshay Jain, Xiaolan Yao, Guangfu Li, Kun Cheng
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immunotherapy using monoclonal antibodies targeting the PD-1/PD-L1 interaction has shown enormous success for various cancers. Despite their encouraging results in clinics, antibody-based checkpoint inhibitors have several limitations, such as poor t
Externí odkaz:
https://doaj.org/article/ee74b832e87d4bc8938b58fcb00184e9
Autor:
Jing Zhou, Yuexu Jiang, Yue Huang, Qiongling Wang, Jussuf T. Kaifi, Eric T. Kimchi, Chiswili Yves Chabu, Zhenguo Liu, Trupti Joshi, Guangfu Li
Publikováno v:
Translational Oncology, Vol 15, Iss 1, Pp 101262- (2022)
Pancreatic cancer (PaC) is resistant to immune checkpoint therapy, but the underlying mechanisms are largely unknown. In this study, we have established four orthotopic PaC murine models with different PaC cell lines by intra-pancreatic inoculation.
Externí odkaz:
https://doaj.org/article/a21934920a644ea9857ba22b86db5b6e
Autor:
Xiaoqiang Qi, Yajun Liu, Samira Hussein, Grace Choi, Eric T. Kimchi, Kevin F. Staveley-O’Carroll, Guangfu Li
Publikováno v:
Cells, Vol 11, Iss 22, p 3684 (2022)
Both preclinical and clinical studies have demonstrated that the modulation of gut microbiota could be a promising strategy for enhancing antitumor immune responses and reducing resistance to immunotherapy in cancer. Various mechanisms, including act
Externí odkaz:
https://doaj.org/article/3e929575f11245f8a8b0057f0f950aaa