Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Guangfen Mao"'
Autor:
Gauthami Jalagadugula, Lawrence E. Goldfinger, Guangfen Mao, Michele P. Lambert, A. Koneti Rao
Publikováno v:
Blood Advances, Vol 2, Iss 7, Pp 797-806 (2018)
Abstract: Patients with RUNX1 haplodeficiency have thrombocytopenia, platelet dysfunction, and deficiencies of α-granules and dense granules. Platelet expression profiling of a patient with a heterozygous RUNX1 mutation (c.969-323G>T) revealed decre
Externí odkaz:
https://doaj.org/article/0d97a35f27784031a8aa180f04379b2d
Autor:
Gauthami Jalagadugula, Guangfen Mao, Lawrence E. Goldfinger, Jeremy Wurtzel, Fabiola Del Carpio-Cano, Michele P. Lambert, Brian Estevez, Deborah L. French, Mortimer Poncz, A. Koneti Rao
Publikováno v:
Blood Advances. 6:5100-5112
Transcription factor RUNX1 is a master regulator of hematopoiesis and megakaryopoiesis. RUNX1 haplodeficiency (RHD) is associated with thrombocytopenia and platelet granule deficiencies and dysfunction. Platelet profiling of our study patient with RH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55ca50f26980f44452fa7b98e80811a6
https://doi.org/10.1182/bloodadvances.2021006945
https://doi.org/10.1182/bloodadvances.2021006945
Autor:
A. Koneti Rao, Rachel A. Myers, Deepak Voora, Fabiola Del Carpio-Cano, Guangfen Mao, Natthapol Songdej, Lawrence E. Goldfinger
Publikováno v:
Circulation. 136:927-939
Background: PCTP (phosphatidylcholine transfer protein) regulates the intermembrane transfer of phosphatidylcholine. Higher platelet PCTP expression is associated with increased platelet responses on activation of protease-activated receptor 4 thromb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cccd236a0218f4749d46b60fb28a28e
https://doi.org/10.1161/circulationaha.116.023711
https://doi.org/10.1161/circulationaha.116.023711
Autor:
AK Rao, Lawrence E. Goldfinger, Michele P. Lambert, Natthapol Songdej, Jeremy G.T. Wurtzel, Guangfen Mao, Fabiola Del Carpio-Cano
Publikováno v:
Blood. 136:25-26
Plasma Factor XIII, a transglutaminase, is a complex of two A (gene F13A1) chains with catalytic activity and two B chains (gene F13B). FXIII induces clot stabilization and retraction via cross-linking of fibrin monomers and other proteins. Factor XI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ab04d6387417e8026c2393bc60138cf
https://doi.org/10.1182/blood-2020-141382
https://doi.org/10.1182/blood-2020-141382
Autor:
A. Koneti Rao, Michele P. Lambert, Guangfen Mao, Lawrence E. Goldfinger, Gauthami Jalagadugula
Patients with RUNX1 haplodeficiency have thrombocytopenia, platelet dysfunction, and deficiencies of α-granules and dense granules. Platelet expression profiling of a patient with a heterozygous RUNX1 mutation (c.969-323G>T) revealed decreased RAB1B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2534edb228f20aecb54cc984be444e42
https://europepmc.org/articles/PMC5894258/
https://europepmc.org/articles/PMC5894258/
Autor:
A. Koneti Rao, Guenther Boden, Gauthami Jalagadugula, Peter Cheung, Andrew A. Wiles, Robert J. Freishtat, Anamika Singh, Guangfen Mao
Publikováno v:
Thrombosis Research. 134:704-710
Introduction Diabetes mellitus (DM) is a prothrombotic and proinflammatory state. Hyperglycemia (HG) is encountered even in patients without DM. We have shown that combined HG and hyperinsulinemia (HI) in healthy non-diabetic subjects increased circu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97fe2e566a8edc6ce01a32a62476065b
https://doi.org/10.1016/j.thromres.2014.06.029
https://doi.org/10.1016/j.thromres.2014.06.029
Autor:
Robert J. Freishtat, D C Fan, Gauthami Jalagadugula, AK Rao, Guangfen Mao, Michele P. Lambert, Lawrence E. Goldfinger
Publikováno v:
Journal of thrombosis and haemostasis : JTH. 15(4)
Essentials Platelet dense granule (DG) deficiency is a major abnormality in RUNX1 haplodeficiency patients. The molecular mechanisms leading to the platelet DG deficiency are unknown. Platelet expression of PLDN (BLOC1S6, pallidin), involved in DG bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b676d9bfaff73fcb61eeaf6baaad300
https://pubmed.ncbi.nlm.nih.gov/28075530
https://pubmed.ncbi.nlm.nih.gov/28075530
Autor:
Guangfen, Mao, Natthapol, Songdej, Deepak, Voora, Lawrence E, Goldfinger, Fabiola E, Del Carpio-Cano, Rachel A, Myers, A Koneti, Rao
Publikováno v:
Circulation. 136(10)
PCTP (phosphatidylcholine transfer protein) regulates the intermembrane transfer of phosphatidylcholine. Higher platelet PCTP expression is associated with increased platelet responses on activation of protease-activated receptor 4 thrombin receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0f9541cf432f89f23b6d1aae896e13cd
https://pubmed.ncbi.nlm.nih.gov/28676520
https://pubmed.ncbi.nlm.nih.gov/28676520
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 31:921-927
Objective— Mutations in the hematopoietic transcription factor RUNX1 cause thrombocytopenia and impaired platelet function. In a patient with a heterozygous mutation in RUNX1, we have described decreased platelet pleckstrin phosphorylation and prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cbcadb0ec38755cde3909943e166b8f
https://doi.org/10.1161/atvbaha.110.221879
https://doi.org/10.1161/atvbaha.110.221879
Publikováno v:
Journal of Thrombosis and Haemostasis. 9:383-391
Summary. Background: Platelet factor 4 (PF4) is an abundant protein stored in platelet α-granules. Several patients have been described with platelet PF4 deficiency, including the gray platelet syndrome, characterized by a deficiency of α-granule p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e21075728aecb988e77596c2830dc611
https://doi.org/10.1111/j.1538-7836.2010.04154.x
https://doi.org/10.1111/j.1538-7836.2010.04154.x