Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Guangfa Xiao"'
Publikováno v:
Cellular Physiology and Biochemistry, Vol 43, Iss 2, Pp 840-851 (2017)
Background/Aims: Pancreatic cancer cells (PCC) is one of the most risky cancers and gemcitabine (GEM) is the standard first-line drug for treating PCC. The PCC will develop drug resistance to GEM after a period of treatment. However, the detailed mol
Externí odkaz:
https://doaj.org/article/49eaa5ba5d314b09926db8e6d9271b49
Publikováno v:
Gastroenterology Research and Practice, Vol 2014 (2014)
The aim of this study was to reveal the associations of microRNA miR-15a and miR-16 dysregulation with clinicopathological characteristics and prognosis in patients with colorectal cancer. As a result, we found that miR-15a and miR-16 expression, det
Externí odkaz:
https://doaj.org/article/db14752faee4451da789e1b6c6a54751
Autor:
Yuzhan Kang, Guangfa Xiao, Hwa Liang Leo, Lei Xia, Hee Joo Poh, Thomas Adi Kurnia Susanto, Shufang Zhang, Tianming Cheng, Xiaoye Tuo, Hanry Yu, Janani Sundararajan, Talha Arooz
Publikováno v:
Biomaterials. 33:7925-7932
Bioartificial liver (BAL) system is promising as an alternative treatment for liver failure. We have developed a bioreactor with stacked sandwich culture plates for the application of BAL. This bioreactor design addresses some of the persistent probl
Publikováno v:
Cancer Cell International
Background Both microRNA (miR)-196a and miR-196b are implicated in normal cell differentiation, proliferation, and in tumorigenesis of various cancer types. Especially, miR-196a exerts a pro-oncogenic influence in colorectal cancer (CRC) cells and mi
Publikováno v:
Lab on a chip. 9(14)
We have developed a microfluidic 3D hepatocyte chip (3D HepaTox Chip) for in vitro drug toxicity testing to predict in vivo drug hepatotoxicity. The 3D HepaTox Chip is based on multiplexed microfluidic channels where a 3D microenvironment is engineer
Autor:
Susanne Ng, Guangfa Xiao, Hanry Yu, Rongbin Han, Hwa Liang Leo, Tianming Cheng, Lei Xia, Xiaoye Tuo
Publikováno v:
Biomaterials. 30(30)
Drug hepatotoxicity testing requires in vitro hepatocyte culture to maintain the long-term and stable liver specific functions. We developed a drug testing platform based on laminar-flow immediate-overlay hepatocyte sandwich perfusion culture. The im
Autor:
Siew Min Ong, Chiang Huen Kang, Guangfa Xiao, Lei Xia, Hwa Liang Leo, Shyi Herng Kan, Hui Huan Tang, Yi-Chin Toh, Shufang Zhang, Hanry Yu, Danny van Noort
Publikováno v:
Biomaterials. 29(29)
We have developed a hepatocyte sandwich culture with improved mass transport properties based on ultra-thin microfabricated porous silicon nitride (Si(3)N(4)) membranes. The dimensions and uniformity of the membrane pores can be configurable, which c
Autor:
Chien-Shing Chen, Shuoyu Xu, Chee Leong Cheng, Aileen Wee, Shi Chang, Huihuan Tang, Ser-Mien Chia, Chiang Huen Kang, Chiang Li Wei, Anju M. Raja, Nancy Tan, Peter T. C. So, Hanary Yu, Guangfa Xiao, Jagath C. Rajapakse, Dean C. S. Tai
Publikováno v:
Journal of Biomedical Optics. 14:044013
We develop a standardized, fully automated, quantification system for liver fibrosis assessment using second harmonic generation microscopy and a morphology-based quantification algorithm. Liver fibrosis is associated with an abnormal increase in col
Publikováno v:
Cancer Cell International; 2014, Vol. 14 Issue 1, p65-79, 15p
Publikováno v:
Journal of Biomedical Optics. 13:064010
Liver fibrosis is associated with an abnormal increase in an extracellular matrix in chronic liver diseases. Quantitative characterization of fibrillar collagen in intact tissue is essential for both fibrosis studies and clinical applications. Common