Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Guangdun Peng"'
Autor:
Ran Wang, Xianfa Yang, Jiehui Chen, Lin Zhang, Jonathan A. Griffiths, Guizhong Cui, Yingying Chen, Yun Qian, Guangdun Peng, Jinsong Li, Liantang Wang, John C. Marioni, Patrick P. L. Tam, Naihe Jing
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Understanding of the molecular drivers of lineage diversification and tissue patterning during primary germ layer development requires in-depth knowledge of the dynamic molecular trajectories of cell lineages across a series of developmental
Externí odkaz:
https://doaj.org/article/843d895fd4d14dc49ffa9a2deb1ffa4e
Autor:
Fangfang Qu, Wenjia Li, Jian Xu, Ruifang Zhang, Jincan Ke, Xiaodie Ren, Xiaogao Meng, Lexin Qin, Jingna Zhang, Fangru Lu, Xin Zhou, Xi Luo, Zhen Zhang, Minhan Wang, Guangming Wu, Duanqing Pei, Jiekai Chen, Guizhong Cui, Shengbao Suo, Guangdun Peng
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Mammalian embryos exhibit sophisticated cellular patterning that is intricately orchestrated at both molecular and cellular level. It has recently become apparent that cells within the animal body display significant heterogeneity, both in t
Externí odkaz:
https://doaj.org/article/eacd895166b546c099665ce9ce153bf8
Publikováno v:
Cell Regeneration, Vol 12, Iss 1, Pp 1-13 (2023)
Abstract The lung is the most critical organ of the respiratory system supporting gas exchange. Constant interaction with the external environment makes the lung vulnerable to injury. Thus, a deeper understanding of cellular and molecular processes u
Externí odkaz:
https://doaj.org/article/81d6549d98f94b8980c9d51e8be8abba
Autor:
He Jax Xu, Yao Yao, Fenyong Yao, Jiehui Chen, Meishi Li, Xianfa Yang, Sheng Li, Fangru Lu, Ping Hu, Shuijin He, Guangdun Peng, Naihe Jing
Publikováno v:
Cell Regeneration, Vol 12, Iss 1, Pp 1-21 (2023)
Abstract Spinal motor neurons deficiency results in a series of devastating disorders such as amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA) and spinal cord injury (SCI). These disorders are currently incurable, while human plurip
Externí odkaz:
https://doaj.org/article/6209b125b4f4406582a2f98911c6bfc9
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 21, Iss 1, Pp 13-23 (2023)
Recent advances of single-cell transcriptomics technologies and allied computational methodologies have revolutionized molecular cell biology. Meanwhile, pioneering explorations in spatial transcriptomics have opened up avenues to address fundamental
Externí odkaz:
https://doaj.org/article/58ed49b1c3f1462c940d594700340b3a
Autor:
Gaowei Chen, Shishi Lai, Guo Bao, Jincan Ke, Xiaogao Meng, Shanshan Lu, Xiaocong Wu, Hua Xu, Fengyi Wu, Yu Xu, Fang Xu, Guo-Qiang Bi, Guangdun Peng, Kuikui Zhou, Yingjie Zhu
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112069- (2023)
Summary: The nucleus accumbens (NAc) plays an important role in motivation and reward processing. Recent studies suggest that different NAc subnuclei differentially contribute to reward-related behaviors. However, how reward is encoded in individual
Externí odkaz:
https://doaj.org/article/e94c9719c5214b39827338da64531465
Autor:
Lu Wen, Guoqiang Li, Tao Huang, Wei Geng, Hao Pei, Jialiang Yang, Miao Zhu, Pengfei Zhang, Rui Hou, Geng Tian, Wentao Su, Jian Chen, Dake Zhang, Pingan Zhu, Wei Zhang, Xiuxin Zhang, Ning Zhang, Yunlong Zhao, Xin Cao, Guangdun Peng, Xianwen Ren, Nan Jiang, Caihuan Tian, Zi-Jiang Chen
Publikováno v:
The Innovation, Vol 3, Iss 6, Pp 100342- (2022)
In recent years, more and more single-cell technologies have been developed. A vast amount of single-cell omics data has been generated by large projects, such as the Human Cell Atlas, the Mouse Cell Atlas, the Mouse RNA Atlas, the Mouse ATAC Atlas,
Externí odkaz:
https://doaj.org/article/1a78fa602643492a9ed17612682e5a2d
Autor:
Denghui Liu, Chi Xu, Wenjun He, Zhimeng Xu, Wenqi Fu, Lei Zhang, Jie Yang, Zhihao Wang, Bing Liu, Guangdun Peng, Dali Han, Xiaolong Bai, Nan Qiao
Publikováno v:
Artificial Intelligence in the Life Sciences, Vol 1, Iss , Pp 100017- (2021)
Deep learning has achieved great successes in traditional fields like computer vision (CV), natural language processing (NLP), speech processing, and more. These advancements have greatly inspired researchers in genomics and made deep learning in gen
Externí odkaz:
https://doaj.org/article/fce659756f01420a94c8d210daa2fceb
Autor:
Yifei Zhou, Xueqing Wang, Mengjiao Song, Zhidong He, Guizhong Cui, Guangdun Peng, Christoph Dieterich, Adam Antebi, Naihe Jing, Yidong Shen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Decreased autophagy is a hallmark of ageing, but its inter-tissue regulation is poorly understood. Here, Zhou et al. identify mir-83 in C. elegans, which is transported across tissues and suppresses autophagy, contributing to age-related decline.
Externí odkaz:
https://doaj.org/article/80b2ae124c734704ad45ea80c8f0c35c
Autor:
Ke Zhang, Fang Yu, Jian Zhu, Sue Han, Jiehui Chen, Xuanyuan Wu, Yingying Chen, Tingyu Shen, Jiaoyang Liao, Wenke Guo, Xianfa Yang, Ran Wang, Yun Qian, Jiaxin Yang, Leping Cheng, Yun Zhao, Chi-Chung Hui, Jinsong Li, Guangdun Peng, Shuijin He, Naihe Jing, Ke Tang
Publikováno v:
Cell Reports, Vol 31, Iss 3, Pp - (2020)
Summary: Recent studies have revealed an essential role for embryonic cortical development in the pathophysiology of neurodevelopmental disorders, including autism spectrum disorder (ASD). However, the genetic basis and underlying mechanisms remain u
Externí odkaz:
https://doaj.org/article/a4429567bc564f6c9b55521ae9a3cf26