Zobrazeno 1 - 10
of 200
pro vyhledávání: '"Guangbo, Ge"'
Autor:
Jing Zhou, Qing Song, Haoze Li, Yicun Han, Yunzhou Pu, Ling Li, Wenqing Rong, Xiaodie Liu, Ziyuan Wang, Jian Sun, Yuqing Song, Xueyan Hu, Guanghao Zhu, Huirong Zhu, Liu Yang, Guangbo Ge, Hongshan Li, Qing Ji
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-23 (2024)
Abstract Background Information transmission between primary tumor cells and immunocytes or stromal cells in distal organs is a critical factor in the formation of pre-metastatic niche (PMN). Understanding this mechanism is essential for developing e
Externí odkaz:
https://doaj.org/article/ec9cf269f99d490988b8549851e4f1e7
Publikováno v:
Biosensors, Vol 14, Iss 6, p 275 (2024)
Human sulfotransferase 1As (hSULT1As) play a crucial role in the metabolic clearance and detoxification of a diverse range of endogenous and exogenous substances, as well as in the bioactivation of some procarcinogens and promutagens. Pharmacological
Externí odkaz:
https://doaj.org/article/a97b5e6ec82f4b29a8e950b54a1b118d
Autor:
Zhijian Xu, Danrong Shi, Jian-Bao Han, Yun Ling, Xiangrui Jiang, Xiangyun Lu, Chuan Li, Likun Gong, Guangbo Ge, Yani Zhang, Yi Zang, Tian-Zhang Song, Xiao-Li Feng, Ren-Rong Tian, Jia Ji, Miaojin Zhu, Nanping Wu, Chunhui Wu, Zhen Wang, Yechun Xu, Cheng Peng, Min Zheng, Junling Yang, Feifei Du, Junliang Wu, Peipei Wang, Jingshan Shen, Jianliang Zhang, Yong-Tang Zheng, Hangping Yao, Weiliang Zhu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-8 (2023)
Abstract Effective drugs with broad spectrum safety profile to all people are highly expected to combat COVID-19 caused by SARS-CoV-2. Here we report that nelfinavir, an FDA approved drug for the treatment of HIV infection, is effective against SARS-
Externí odkaz:
https://doaj.org/article/cbeb9c93ea5442cba5846201420e2c42
Autor:
Jia Lai, Yueyue Li, Mei Ran, Qianqian Huang, Feihong Huang, Linjie Zhu, Yuesong Wu, Wenjun Zou, Xiang Xie, Yong Tang, Fei Yang, Anguo Wu, Guangbo Ge, Jianming Wu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 163, Iss , Pp 114811- (2023)
Background: Thrombocytopenia is a common hematological disease caused by many factors. It usually complicates critical diseases and increases morbidity and mortality. The treatment of thrombocytopenia remains a great challenge in clinical practice, h
Externí odkaz:
https://doaj.org/article/73d5755fffa74c8a890b189698273ba5
Autor:
Yuhui Ma, Hong Xu, Gang Chen, Wei Liu, Chao Ma, Jialei Meng, Lin Yuan, Xu Hua, Guangbo Ge, Ming Lei
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: Acute lung injury (ALI) is a common clinical disease with high mortality. Rujin Jiedu powder (RJJD) has been clinically utilized for the treatment of ALI in China, but the active constituents in RJJD and its protective mechanisms against
Externí odkaz:
https://doaj.org/article/16df6c2896424f16ba4c9125be945bdf
Autor:
Tiantian Zhang, Feng Zhang, Yani Zhang, Hongxin Li, Guanghao Zhu, Taotao Weng, Cheng Huang, Ping Wang, Yuqi He, Jing Hu, Guangbo Ge
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Alisol B 23-acetate (AB23A), a major bioactive constituent in the Chinese herb Zexie (Rhizoma Alismatis), has been found with multiple pharmacological activities. AB23A can be readily hydrolyzed to alisol B in mammals, but the hydrolyti
Externí odkaz:
https://doaj.org/article/624075f4c5e74f53948b2fc6bc3017b3
Publikováno v:
Advanced Science, Vol 10, Iss 7, Pp n/a-n/a (2023)
Abstract Dysregulated epigenetic modifications dynamically drive the abnormal transcription process to affect the tumor microenvironment; thus, promoting cancer progression, drug resistance, and metastasis. Nowadays, therapies targeting epigenetic dy
Externí odkaz:
https://doaj.org/article/9145d3d6bda244d6bcc6b8b1f9e37db8
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 3, Pp 1068-1099 (2022)
Drug-metabolizing enzymes (DMEs), a diverse group of enzymes responsible for the metabolic elimination of drugs and other xenobiotics, have been recognized as the critical determinants to drug safety and efficacy. Deciphering and understanding the ke
Externí odkaz:
https://doaj.org/article/26af5e5a95de47ab88ef509d59f2b96f
Autor:
Feng Zhang, Tiantian Zhang, Jiahao Gong, Qinqin Fang, Shenglan Qi, Mengting Li, Yan Han, Wei Liu, Guangbo Ge
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Human cytochrome P450 3A4 (hCYP3A4) is a predominant enzyme to trigger clinically relevant drug/herb-drug interactions (DDIs or HDIs). Although a number of herbal medicines have been found with strong anti-hCYP3A4 effects in vitro, the in vivo modula
Externí odkaz:
https://doaj.org/article/354bafa35d314a7a87f7237f88d4ba18
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Oxidative stress contributes greatly to initiation and progression of liver injury. Activation of nuclear-factor erythroid 2-related factor 2 (Nrf2) has been considered as an attractive strategy for preventing and treating the oxidative damage relate
Externí odkaz:
https://doaj.org/article/d8560f6534af4c5a98df7a2eac58d157