Zobrazeno 1 - 10
of 203
pro vyhledávání: '"GuangDi Wang"'
Publikováno v:
Pharmaceutics, Vol 16, Iss 8, p 1024 (2024)
Cancer stem cells (CSCs) possess a significant ability to renew themselves, which gives them a strong capacity to form tumors and expand to encompass additional body areas. In addition, they possess inherent resistance to chemotherapy and radiation t
Externí odkaz:
https://doaj.org/article/8d282085a4f14b8fa8ff4ce04a642212
Autor:
Ava M. Boston, Abdulrahman M. Dwead, Marwah M. Al-Mathkour, Kezhan Khazaw, Jin Zou, Qiang Zhang, Guangdi Wang, Bekir Cinar
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107964- (2023)
Summary: The Polycomb group protein SCML2 and the transcriptional cofactor YAP1 regulate diverse cellular biology, including stem cell maintenance, developmental processes, and gene regulation in mammals and flies. However, their molecular and functi
Externí odkaz:
https://doaj.org/article/78e417cc88024ae884d334fc7ecab81b
Autor:
Taaliah Campbell, Ohuod Hawsawi, Veronica Henderson, Precious Dike, Bor-Jang Hwang, Yusuf Liadi, ElShaddai Z. White, Jin Zou, GuangDi Wang, Qiang Zhang, Nathan Bowen, Derrick Scott, Cimona V. Hinton, Valerie Odero-Marah
Publikováno v:
Heliyon, Vol 9, Iss 4, Pp e14810- (2023)
Oxidative stress is increased in several cancers including prostate cancer, and is currently being exploited in cancer therapy to induce ferroptosis, a novel nonapoptotic form of cell death. High mobility group A2 (HMGA2), a non-histone protein up-re
Externí odkaz:
https://doaj.org/article/7796c4b5fd0748a9ae78a06ee50a2c9b
Autor:
Inderpal Sekhon, Guanglin Chen, Keyara Piri, Seiji Shinkawa, Dennis Ashong, Qiang Zhang, Guangdi Wang, Qiao-Hong Chen
Publikováno v:
Molecules, Vol 28, Iss 12, p 4743 (2023)
Androgen receptor (AR) is a viable therapeutic target for lethal castration-resistant prostate cancer (CRPC), because the continued progression of CRPC is mainly driven by the reactivation of AR transcriptional activity. The current FDA-approved AR a
Externí odkaz:
https://doaj.org/article/b55b50b61e154f0da93eb972b26fc9cb
Autor:
Borui Kang, Madhusoodanan Mottamal, Qiu Zhong, Melyssa Bratton, Changde Zhang, Shanchun Guo, Ahamed Hossain, Peng Ma, Qiang Zhang, Guangdi Wang, Florastina Payton-Stewart
Publikováno v:
Pharmaceuticals, Vol 16, Iss 5, p 735 (2023)
Niclosamide effectively downregulates androgen receptor variants (AR-Vs) for treating enzalutamide and abiraterone-resistant prostate cancer. However, the poor pharmaceutical properties of niclosamide due to its solubility and metabolic instability h
Externí odkaz:
https://doaj.org/article/a6130f7ca6f84e439096e3bc86c740c5
Publikováno v:
ACS Omega, Vol 6, Iss 14, Pp 9334-9343 (2021)
Externí odkaz:
https://doaj.org/article/94ddfa3572394e849609c505085d8fdc
Autor:
Sitong Wu, Guanglin Chen, Eva Y. Chen, Leyla S. Farshidpour, Qiang Zhang, Guangdi Wang, Qiao-Hong Chen
Publikováno v:
Pharmaceuticals, Vol 16, Iss 4, p 531 (2023)
Silibinin, also known as silybin, is isolated from milk thistle (Silybum marianum). Silibinin has been demonstrated to be a good lead compound due to its potential to prevent and treat prostate cancer. Its moderate potency and poor pharmacokinetic pr
Externí odkaz:
https://doaj.org/article/04afc51a05aa4c3a92eafde352004316
Autor:
Qiling Li, Qi Wang, Wei Xu, Yamin Ma, Qing Wang, Danita Eatman, Shaojin You, Jin Zou, James Champion, Lanbo Zhao, Ye Cui, Wenzhi Li, Yangyang Deng, Li Ma, Biao Wu, Guangdi Wang, Xiaodong Zhang, Qingwei Wang, Mohamed A. Bayorh, Qing Song
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Obesity is characterized by low-grade chronic inflammation. As an acute-phase reactant to inflammation and infection, C-reactive protein (CRP) has been found to be the strongest factor associated with obesity. Here we show that chronic elevation of h
Externí odkaz:
https://doaj.org/article/71e3c7e93488466fbd0f1cbe850259a1
Publikováno v:
Molecules, Vol 26, Iss 21, p 6421 (2021)
To search for novel androgen receptor (AR) modulators for the potential treatment of castration-resistant prostate cancer (CRPC), naturally occurring silibinin was sought after as a lead compound because it possesses a moderate potency towards AR-pos
Externí odkaz:
https://doaj.org/article/e523de46002940f9b5086286570ef89c
Autor:
Jingwei Wan, Alyssa Aihui Guo, Indrajit Chowdhury, Shanchun Guo, Jacqueline Hibbert, Guangdi Wang, Mingli Liu
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Objectives: Our previous findings demonstrate that channel-kinase transient receptor potential (TRP) ion channel subfamily M, member 7 (TRPM7) is critical in regulating human glioma cell migration and invasion. Since microRNAs (miRNAs) participate in
Externí odkaz:
https://doaj.org/article/4e1c02731af8401782e9fa1df8d2fc3b