Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Guang-zhong Wang"'
Autor:
Renrui Chen, Ziang Zhang, Junjie Ma, Bing Liu, Zhengyun Huang, Ganlu Hu, Ju Huang, Ying Xu, Guang-Zhong Wang
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract Tissue specificity is a fundamental property of an organ that affects numerous biological processes, including aging and longevity, and is regulated by the circadian clock. However, the distinction between circadian-affected tissue specifici
Externí odkaz:
https://doaj.org/article/7b1d589572fd439f8941cfafb5730493
Autor:
Yu-kun Zheng, Zhong-shi Zhou, Guang-zhong Wang, Ji-yuan Tu, Huan-bo Cheng, Shang-zhi Ma, Chang Ke, Yan Wang, Qi-pan Jian, Yu-hang Shu, Xiao-wei Wu
Publikováno v:
Cell Death and Disease, Vol 14, Iss 4, Pp 1-11 (2023)
Abstract The 5-year survival rate of non-small cell lung cancer (NSCLC) patients is very low. MicroRNAs (miRNAs) are involved in the occurrence of NSCLC. miR-122-5p interacts with wild-type p53 (wtp53), and wtp53 affects tumor growth by inhibiting th
Externí odkaz:
https://doaj.org/article/587a6d16b4f444b3a51c2f6f4d402a00
Autor:
Tingting Bo, Jie Li, Ganlu Hu, Ge Zhang, Wei Wang, Qian Lv, Shaoling Zhao, Junjie Ma, Meng Qin, Xiaohui Yao, Meiyun Wang, Guang-Zhong Wang, Zheng Wang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
A comprehensive anatomically-defined atlas of brain transcriptomics in macaques is still lacking. Here, the authors generate complementary bulk RNA-seq and snRNA-seq datasets from cynomolgus macaques to examine the link between brain-wide gene expres
Externí odkaz:
https://doaj.org/article/80902548f9714a31a09d2c6c95a8f084
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 4301-4311 (2023)
Although the individual transcriptional regulators of the core circadian clock are distinct among different organisms, the autoregulatory feedback loops they form are conserved. This unified design principle explains how daily physiological activitie
Externí odkaz:
https://doaj.org/article/1c76ca53b1644ae3886b908ba9a7f4fa
Autor:
Wei Wang, Tingting Bo, Ge Zhang, Jie Li, Junjie Ma, Liangxiao Ma, Ganlu Hu, Huige Tong, Qian Lv, Daniel J. Araujo, Dong Luo, Yuejun Chen, Meiyun Wang, Zheng Wang, Guang-Zhong Wang
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112652- (2023)
Summary: Brain-derived transcriptomes are known to correlate with resting-state brain activity in humans. Whether this association holds in nonhuman primates remains uncertain. Here, we search for such molecular correlates by integrating 757 transcri
Externí odkaz:
https://doaj.org/article/c1aa20885aa44378bbffb3a2892519ee
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Integrative analysis of the high-resolution baboon diurnal transcriptome, provides insights into the effect of circadian rhythm on the whole-body primate gene network.
Externí odkaz:
https://doaj.org/article/43203f45f5cf4e2097175e00c316a535
Autor:
Zongyang Lu, Jie Li, Yong Lu, Ling Li, Wei Wang, Chenchen Zhang, Libing Xu, Yanhong Nie, Changshan Gao, Xinyan Bian, Zhen Liu, Guang-Zhong Wang, Qiang Sun
Publikováno v:
The Innovation, Vol 4, Iss 3, Pp 100436- (2023)
Genomic imprinting can lead to allele-specific expression (ASE), where one allele is preferentially expressed more than the other. Perturbations in genomic imprinting or ASE genes have been widely observed across various neurological disorders, notab
Externí odkaz:
https://doaj.org/article/66c0a6668ca14d2fbdd7b3b529541d89
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/a8df20d567694d598f3db62002f941b1
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/6654ae52f93f49b9a8b1c1b8e80095f1
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 1914-1924 (2020)
Circadian rhythms are 24-hour oscillations affecting an organism at multiple levels from gene expression all the way to tissues and organs. They have been observed in organisms across the kingdom of life, spanning from cyanobacteria to humans. In mam
Externí odkaz:
https://doaj.org/article/391f9a8eaba6486f93931e8e5913a9f8