Zobrazeno 1 - 10
of 335
pro vyhledávání: '"Guang-bo Ge"'
Autor:
Ji-Hua Shi, Nuo Cheng, Wen Zhang, Qiang Jin, Wen-Zhi Guo, Guang-Bo Ge, Shui-Jun Zhang, Pål-Dag Line, Yong Wang
Publikováno v:
Heliyon, Vol 9, Iss 8, Pp e19150- (2023)
Background.Normothermic machine perfusion (NMP) could provide protection to organs from donation after circulatory death (DCD) before transplantation, and its molecular mechanism remains unclear. Our previous study discovered that the air-ventilated
Externí odkaz:
https://doaj.org/article/472a1957f83440a8bd4efa9e657891a6
Autor:
Ping-lan Lin, Tao-tao Weng, Lian-xiang Duan, Lin-zhang Zhang, Xia Wei, Sheng-lan Qi, Jia-wen You, Yu Cao, Guang-bo Ge, Wei Liu, Xiao-li He, Jing Hu
Publikováno v:
Heliyon, Vol 9, Iss 7, Pp e17908- (2023)
Renal fibrosis (RF) is a common pathological feature of chronic kidney disease (CKD), which remains a major public health problem. As now, there is still lack of chemical or biological drugs to reverse RF. Shen-shuai-yi Recipe (SSYR) is a classical C
Externí odkaz:
https://doaj.org/article/fc191b6cd4bd437dbc7daac88e9540bf
Autor:
Chun-Yu Li, Hao-Nan Wang, Guang-Hao Zhu, Li-Lin Song, Xu-Dong Hou, Peng-Chao Huo, Jie Hou, Guang-Bo Ge
Publikováno v:
Acta Materia Medica, Vol 1, Iss 2, Pp 164-176 (2022)
Bile salt hydrolases (BSHs) play crucial roles in the deconjugation of conjugated bile acids and therefore are key targets for modulating bile acid metabolism. This study aimed to identify efficacious BSH inhibitors from a natural compound library an
Externí odkaz:
https://doaj.org/article/3de1fcf5b4884ec5b805f39a7db14a8f
Autor:
Ji-Hua Shi, Dong-Jing Yang, Qiang Jin, Nuo Cheng, Yuan-Bin Shi, Yang Bai, Dong-Sheng Yu, Wen-Zhi Guo, Guang-Bo Ge, Shui-Jun Zhang
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract The optimal oxygen concentration is unclear for normothermic machine perfusion (NMP) of livers from donation after circulatory death (DCD). Our purposes were to investigate the effect of air-ventilated NMP on the DCD liver, analyze the under
Externí odkaz:
https://doaj.org/article/e594381fab83486397154032e2089adf
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/b9c753da3ce94ee0b651e9c9512b6a76
Publikováno v:
MedComm, Vol 3, Iss 3, Pp n/a-n/a (2022)
Abstract The main proteases (Mpro), also termed 3‐chymotrypsin‐like proteases (3CLpro), are a class of highly conserved cysteine hydrolases in β‐coronaviruses. Increasing evidence has demonstrated that 3CLpros play an indispensable role in vir
Externí odkaz:
https://doaj.org/article/30994d64257641fbb47e256dd8ba6b98
Publikováno v:
Biosensors, Vol 13, Iss 4, p 476 (2023)
Enzymes constitute an extremely important class of biomacromolecules with diverse catalytic functions, which have been validated as key mediators for regulating cellular metabolism and maintaining homeostasis in living organisms [...]
Externí odkaz:
https://doaj.org/article/53c433820fce4b32881014ca930fcd42
Autor:
Fang-Yuan Wang, Ping Wang, Dong-Fang Zhao, Frank J. Gonzalez, Yu-Fan Fan, Yang-Liu Xia, Guang-Bo Ge, Ling Yang
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 11, Iss 1, Pp 15-27 (2021)
Mammalian catechol-O-methyltransferases (COMT) are an important class of conjugative enzymes, which play a key role in the metabolism and inactivation of catechol neurotransmitters, catechol estrogens and a wide range of endobiotics and xenobiotics t
Externí odkaz:
https://doaj.org/article/2d086892302e4f9ab82753f5017da322
Autor:
Ya-Di Zhu, Hui-Lin Pang, Qi-Hang Zhou, Zi-Fei Qin, Qiang Jin, Moshe Finel, Yi-Nan Wang, Wei-Wei Qin, Yin Lu, Dan-Dan Wang, Guang-Bo Ge
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 10, Iss 3, Pp 263-270 (2020)
The human UDP-glucuronosyltransferase 1A1 (UGT1A1), one of the most essential conjugative enzymes, is responsible for the metabolism and detoxification of bilirubin and other endogenous substances, as well as many different xenobiotic compounds. Deci
Externí odkaz:
https://doaj.org/article/7319b531540a498d93b4b14eb32543d8
Autor:
Hui-Lin Pang, Guang-Hao Zhu, Qi-Hang Zhou, Chun-Zhi Ai, Ya-Di Zhu, Ping Wang, Tong-Yi Dou, Yang-Liu Xia, Hong Ma, Guang-Bo Ge
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Human UDP-glucuronosyltransferase 1A1 (hUGT1A1) is one of the most essential phase II enzymes in humans. Dysfunction or strong inhibition of hUGT1A1 may result in hyperbilirubinaemia and clinically relevant drug/herb-drug interactions (DDIs/HDIs). Re
Externí odkaz:
https://doaj.org/article/6efdbc92ace844f68566251854ee9568