Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Guang-Qian Xiao"'
Autor:
Won Kyung Kim, Alyssa J. Buckley, Dong-Hoon Lee, Alex Hiroto, Christian H. Nenninger, Adam W. Olson, Jinhui Wang, Zhuo Li, Rajeev Vikram, Yao Mawulikplimi Adzavon, Tak-yu Yau, Yigang Bao, Michael Kahn, Joseph Geradts, Guang-Qian Xiao, Zijie Sun
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Androgen deprivation therapy (ADT) targeting androgen/androgen receptor (AR)- signaling pathways is the main therapy for advanced prostate cancer (PCa). However, ADT eventually fails in most patients who consequently develop castration-resis
Externí odkaz:
https://doaj.org/article/8c69e3a71f664fe7bd43113f313a328f
Autor:
Alex Hiroto, Won Kyung Kim, Ariana Pineda, Yongfeng He, Dong-Hoon Lee, Vien Le, Adam W. Olson, Joseph Aldahl, Christian H. Nenninger, Alyssa J. Buckley, Guang-Qian Xiao, Joseph Geradts, Zijie Sun
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Prostate stromal cells can contribute to prostate tumorigenesis. Here the authors show that the loss of androgen receptor signalling in Gli1-lineage stromal cells diminishes prostate epithelial oncogenic transformation and tumor growth in mouse model
Externí odkaz:
https://doaj.org/article/427aea55475646a3858237aad5344a31
Autor:
Mahmut Akgul, Robert Humble, Abdullah Osme, Servet Yuce, Elif N. Kocak, Parisa Najafzadeh, Ankur Sangoi, Niharika Pattnaik, Sourav Mishra, Shivani Sharma, Nada Shaker, Seema Kaushal, Manas Baisakh, Andrea R. Lightle, Bonnie L. Balzer, Guang-Qian Xiao, Gregory T. MacLennan, Adeboye O. Osunkoya, Anil Parwani, Liang Cheng, Andrew Bellizzi, Sambit K. Mohanty
Publikováno v:
Diagnostic Pathology, Vol 17, Iss 1, Pp 1-9 (2022)
Highlights Clear cell adenocarcinoma of the lower urinary tract is rare, with heterogenous morphology. GATA3 expression can be seen in these tumors, causing diagnostic challenge in the urinary tract or in the metastatic setting. Along with morphologi
Externí odkaz:
https://doaj.org/article/a13b80eadd6f4057b0a3d25f73462a24
Autor:
Jie Ding, Xin-Gang Cui, Hao-Jie Chen, Yin Sun, Wei-Wei Yu, Jie Luo, Guang-Qian Xiao, Chawnshang Chang, Jun Qi, Shuyuan Yeh
Publikováno v:
Cancers, Vol 14, Iss 7, p 1639 (2022)
Vasculogenic mimicry (VM) has been reported as an alternative channel to increase tumor nutrient supplies and accelerate tumor progression, and is associated with poor survival prognosis in multiple cancers, including renal cell carcinoma (RCC). The
Externí odkaz:
https://doaj.org/article/c0134a94c4b04f3eaeeb15f220dcc6d0
Autor:
Elizabeth A Guancial, Deepak Kilari, Guang-Qian Xiao, Sohaib H Abu-Farsakh, Andrea Baran, Edward M Messing, Eric S Kim
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155503 (2016)
BACKGROUND:Platinum (Pt)-based chemotherapy is the standard of care for muscle-invasive bladder cancer (MIBC). However, resistance is a major limitation. Reduced intratumoral drug accumulation is an important mechanism of platinum resistance. Our gro
Externí odkaz:
https://doaj.org/article/2e925e2eec2c40258198aacc2221b937
Autor:
Guang-Qian Xiao, Pamela Unger, Qi Yang, Yayoi Kinoshita, Kyra Singh, Loralee McMahon, Kent Nastiuk, Kai Sha, John Krolewski, David Burstein
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121318 (2015)
PLZF is a transcription repressor, which plays a critical role in development, spermatogenesis and oncogenesis. Down-regulation of PLZF has been found in various tumor cell lines. There has been virtually no tissue study on the expression of PLZF in
Externí odkaz:
https://doaj.org/article/31f6bac41e4648e9b5818f06acc69fba
Autor:
Mahul B. Amin, Andy Sherrod, Guang-Qian Xiao, Zhengshan Chen, Huy P. Pham, Manju Aron, Andre Luis de Castro Abreu
Publikováno v:
Human Pathology. 118:18-29
Summary Cribriform Gleason pattern 4 (CGP4) is an indicator of poor prognosis in Gleason Score 7 prostate cancer; however, the significance of the size and percentage of this pattern and the presence of concomitant intraductal carcinoma (IDC) in thes
Publikováno v:
The ProstateREFERENCES.
Castration-resistance is common in advanced prostatic adenocarcinomas (PACs) treated with androgen deprivation therapy (ADT) and usually occurs after 2 years following treatment. A minority of PACs confer innate ADT resistance without prior hormonal
Publikováno v:
Cureus. 14(5)
Papillary renal cell carcinoma (PRCC) with micropapillary carcinoma (MC) has been rarely described. We conducted a retrospective descriptive evaluation of the association of MC with PRCC and the possible prognostic implications.A database search was
Autor:
Andy Sherrod, Guang-Qian Xiao
Publikováno v:
Translational Andrology and Urology. 9:2292-2295