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Akademický článek

Mutations in the gene DNAJC5 cause autosomal dominant Kufs disease in a proportion of cases: study of the Parry family and 8 other families.

Autor: Milen Velinov, Natalia Dolzhanskaya, Michael Gonzalez, Eric Powell, Ioanna Konidari, William Hulme, John F Staropoli, Winnie Xin, Guang Y Wen, Rosemary Barone, Scott H Coppel, Katherine Sims, W Ted Brown, Stephan Züchner

Publikováno v: PLoS ONE, Vol 7, Iss 1, p e29729 (2012)

The Neuronal Ceroid Lipofuscinoses (NCL) comprise at least nine progressive neurodegenerative genetic disorders. Kufs disease, an adult-onset form of NCL may be recessively or dominantly inherited. Our study aimed to identify genetic mutations associ

Externí odkaz: https://doaj.org/article/da6f590e98dc4500b26f6f0b6d91c488

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Aberrant hippocampal Atp8a1 levels are associated with altered synaptic strength, electrical activity, and autistic-like behavior

Autor: Probal Banerjee, Silvia Menkes, Alexandra Marsillo, Guang Y. Wen, Abha Chauhan, Tatyana Budylin, Sara R. Guariglia, Andrzej Wieraszko, Rodina Sadek, Daniel P. McCloskey, Daniel J. Kerr

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1862:1755-1765

Type IV ATPases are putative aminophospholipid translocases (APLTs), more commonly known as flippases. A pronounced induction of the flippase Atp8a1 was observed in post-mortem tissue homogenates from the hippocampus and temporal lobe of juvenile aut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df58895b156e19559406829ee5e47d1e
https://doi.org/10.1016/j.bbadis.2016.06.005

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A Novel p.Leu(381)Phe Mutation in Presenilin 1 is Associated with Very Early Onset and Unusually Fast Progressing Dementia as well as Lysosomal Inclusions Typically Seen in Kufs Disease

Autor: Emil Alexov, Guang Y. Wen, Milen Velinov, Stephan Züchner, Natalia Dolzhanskaya, Fiorella Sperziani, Michael A. Gonzalez, Jeffrey Messing, Shannon K. Stefl

Publikováno v: Journal of Alzheimer's Disease. 39:23-27

Whole exome sequencing in a family with suspected dominant Kufs disease identified a novel Presenilin 1 mutation p.Leu(381)Phe in three brothers who, along with their father, developed progressive dementia and motor deficits in their early 30s. All a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76306ee948fc386f6d1cec8d90b98c13
https://doi.org/10.3233/jad-131340

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Digallate Dimers of (−)-Epigallocatechin Gallate Inactivate Herpes Simplex Virus

Autor: Sharon L. Hillier, George Merz, Lisa C. Rohan, Guang Y. Wen, Weimin Xu, Charles E. Isaacs

Publikováno v: Antimicrobial Agents and Chemotherapy. 55:5646-5653

Topical microbicides are potentially an alternative method to vaccines for reducing the spread of herpes simplex virus (HSV). We have previously shown (S. Liu et al., Biochim. Biophys. Acta 1723:270–281, 2005) that the catechin (−)-epigallocatech

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a8ecb8236ec3f9018d8c88f0a133afd
https://doi.org/10.1128/aac.05531-11

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Epigallocatechin Gallate Inactivates Clinical Isolates of Herpes Simplex Virus

Autor: Charles E. Isaacs, Christopher Corbo, Edmund C. Jenkins, Weimin Xu, Guang Y. Wen, Vincenzo Di Maggio, Sharon L. Hillier, Lisa C. Rohan, Jun Hua Jia

Publikováno v: Antimicrobial Agents and Chemotherapy. 52:962-970

In the absence of a fully effective herpes simplex virus (HSV) vaccine, topical microbicides represent an important strategy for preventing HSV transmission. (−)-Epigallocatechin gallate (EGCG) (molecular weight, 458.4) is the primary catechin in g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c04bc96f978c8d31e33645ddbfa22d82
https://doi.org/10.1128/aac.00825-07

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Title Page / Contents / Introduction / Materials and Methods / References and Bibliography / Acknowledgement

Autor: Henryk M. Wisniewski, Guang Y. Wen, Judy W. Shek

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::38328573b62753a35fc16a60291b068a
https://doi.org/10.1159/000409321

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Brush-like fibers on the human chromosome periphery

Autor: Erick M. Goldberg, Marilyn Genovese, Guang Y. Wen, Edmund C. Jenkins, Mariel B. Fisher

Publikováno v: Scanning. 25:316-320

A brush-like border apparently composed of fibers protruding from metaphase chromosomes of human lymphocytes was observed for the first time using transmission (TEM) and scanning electron microscopy (SEM). On the basis of size and sensitivity to colc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f4a2bbebbc8c6919aae3e8983cd37ee
https://doi.org/10.1002/sca.4950250608

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