Zobrazeno 1 - 10
of 286
pro vyhledávání: '"Guang Xian Zhang"'
Autor:
Reza Yazdani, Hamed Naziri, Gholamreza Azizi, Bogoljub Ciric, Mozhde Askari, Amir Moghadam Ahmadi, Jaya Aseervatham, Guang-Xian Zhang, Abdolmohamad Rostami
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-11 (2024)
Abstract Background Interleukin-37 (IL-37) has anti-inflammatory properties in innate and adaptive immunity. Patients with multiple sclerosis (MS), an autoimmune inflammatory demyelinating disease of the central nervous system (CNS), have increased s
Externí odkaz:
https://doaj.org/article/f766f736534e407bbfe611215a4bc599
Autor:
Gholamreza Azizi, Bram Van den Broek, Larissa Lumi Watanabe Ishikawa, Hamed Naziri, Reza Yazdani, Guang-Xian Zhang, Bogoljub Ciric, Abdolmohamad Rostami
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-15 (2024)
Abstract Background The IL-7 receptor alpha (IL-7Rα) binds both IL-7 and thymic stromal lymphopoietin (TSLP). IL-7Rα is essential for the development and survival of naive CD4+ T cells and their differentiation to effector/memory CD4+ T cells. Mice
Externí odkaz:
https://doaj.org/article/846668fffe0b4fe28d72c1b46acd5f96
Autor:
Reza Yazdani, Mozhde Askari, Amir Moghadam Ahmadi, Gholamreza Azizi, Bogoljub Ciric, Alexandra Boehm, Guang-Xian Zhang, Abdolmohamad Rostami
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The essential role of interleukin 7 (IL-7) signaling via its receptor (IL-7Rα; CD127) in T cell development and function has been well documented. However, CD127 expression and function in myeloid cells, including monocytes, are less clear, especial
Externí odkaz:
https://doaj.org/article/31229c9f1ad6485db018cffdd4e169c2
Autor:
Yazdani, Reza, Askari, Mozhde, Ahmadi, Amir Moghadam, Azizi, Gholamreza, Ciric, Bogoljub, Boehm, Alexandra, Guang-Xian Zhang, Rostami, Abdolmohamad
Publikováno v:
Frontiers in Immunology; 2024, p1-9, 9p
Autor:
Yuan Zhang, Xin-Yu Lu, Ze-Qin Ye, Bogoljub Ciric, Cun-Gen Ma, Abdolmohamad Rostami, Xing Li, Guang-Xian Zhang
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Externí odkaz:
https://doaj.org/article/f51d2ee1aace4b1fa6263368dd69d803
SIRT1 inactivation switches reactive astrocytes to an antiinflammatory phenotype in CNS autoimmunity
Autor:
Weifeng Zhang, Dan Xiao, Xing Li, Yuan Zhang, Javad Rasouli, Giacomo Casella, Alexandra Boehm, Daniel Hwang, Larissa L.W. Ishikawa, Rodolfo Thome, Bogoljub Ciric, Mark T. Curtis, Abdolmohamad Rostami, Guang-Xian Zhang
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 22 (2022)
Astrocytes are highly heterogeneous in their phenotype and function, which contributes to CNS disease, repair, and aging; however, the molecular mechanism of their functional states remains largely unknown. Here, we show that activation of sirtuin 1
Externí odkaz:
https://doaj.org/article/6a88e9f7e5d74a7c842c4e33e2a93d55
Autor:
Javad Rasouli, Giacomo Casella, Weifeng Zhang, Dan Xiao, Gaurav Kumar, Paolo Fortina, Guang-Xian Zhang, Bogoljub Ciric, Abdolmohamad Rostami
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
GM-CSF-producing T helper (Th) cells play a crucial role in the pathogenesis of autoimmune diseases such as multiple sclerosis (MS). Recent studies have identified a distinct population of GM-CSF-producing Th cells, named ThGM cells, that also expres
Externí odkaz:
https://doaj.org/article/d37972e517d44559ab77f8964d478ce0
Autor:
Dan Xiao, Weifeng Zhang, Qing Wang, Xing Li, Yuan Zhang, Javad Rasouli, Giacomo Casella, Bogoljub Ciric, Mark Curtis, Abdolmohamad Rostami, Guang-Xian Zhang
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 755-764 (2021)
Inducible conditional knockout mice are important tools for studying gene function and disease therapy, but their generation is costly and time-consuming. We introduced clustered regularly interspaced short palindromic repeats (CRISPR) and Cre into a
Externí odkaz:
https://doaj.org/article/6866c8fcb81e45ca835208c0278dd192
Autor:
Javad Rasouli, Giacomo Casella, Larissa L. W. Ishikawa, Rodolfo Thome, Alexandra Boehm, Adam Ertel, Carolina R. Melo-Silva, Elisabeth R. Mari, Patrizia Porazzi, Weifeng Zhang, Dan Xiao, Luis J. Sigal, Paolo Fortina, Guang-Xian Zhang, Abdolmohamad Rostami, Bogoljub Ciric
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
IFN-β has been the treatment for multiple sclerosis (MS) for almost three decades, but understanding the mechanisms underlying its beneficial effects remains incomplete. We have shown that MS patients have increased numbers of GM-CSF+ Th cells in ci
Externí odkaz:
https://doaj.org/article/5b73622522934dc1a2b4a1b2ed9a906b
Autor:
Yan-Hua Li, Fang Xu, Rodolfo Thome, Min-Fang Guo, Man-Luan Sun, Guo-Bin Song, Rui-lan Li, Zhi Chai, Bogoljub Ciric, A. M. Rostami, Mark Curtis, Cun-Gen Ma, Guang-Xian Zhang
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-11 (2019)
Abstract Background Unrestrained activation of Th1 and Th17 cells is associated with the pathogenesis of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). While inactivation of dynamin-related protein 1 (Drp1),
Externí odkaz:
https://doaj.org/article/094ed0de9a7743979f7df0a7bd72704c