Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Guang Xi Yu"'
Autor:
Jin-Bo Niu, Chun-Hua Quan, Yuan Liu, Guang-Xi Yu, Jia-Jia Yang, Yin-Ru Li, Yan-Bing Zhang, Ying-Qiu Qi, Jian Song, Cheng-Yun Jin, Sai-Yang Zhang
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1715-1731 (2021)
Hippo signalling pathway plays a crucial role in tumorigenesis and cancer progression. In this work, we identified an N-aryl sulphonamide-quinazoline derivative, compound 9i as an anti-gastric cancer agent, which exhibited potent antiproliferative ab
Externí odkaz:
https://doaj.org/article/8ef17c5ecd874c5ebebd48e3d50c3f93
Autor:
Chong Liu, Jian Song, Xin-Xin Cui, Wen-Bo Liu, Yin-Ru Li, Guang-Xi Yu, Xin-Yi Tian, Ya-Feng Wang, Yang Liu, Sai-Yang Zhang
Publikováno v:
Arabian Journal of Chemistry, Vol 15, Iss 3, Pp 103644- (2022)
In this work, a series of novel 1,2,4-triazine-chalcone hybrids were designed through the molecular hybridization strategy, synthesized by two step chlorinations and further aldol condensation and evaluated their antiproliferative activity against MG
Externí odkaz:
https://doaj.org/article/3178ed9210dd4b6c8d738a9a4b82750a
Autor:
Guang-Xi Yu, Ying Hu, Wei-Xin Zhang, Xin-Yi Tian, Sai-Yang Zhang, Yan Zhang, Shuo Yuan, Jian Song
Publikováno v:
Molecules, Vol 27, Iss 15, p 4996 (2022)
[1,2,4]Triazolo[1,5-a]pyrimidine and indole skeletons are widely used to design anticancer agents. Therefore, in this work, a series of [1,2,4]triazolo[1,5-a]pyrimidine indole derivatives were designed and synthesized by the molecular hybridization s
Externí odkaz:
https://doaj.org/article/df1d6f0c375545b48f306b2cc78d8810
Autor:
Yong-Feng Guan, Xiu-Juan Liu, Xin-Ying Yuan, Wen-Bo Liu, Yin-Ru Li, Guang-Xi Yu, Xin-Yi Tian, Yan-Bing Zhang, Jian Song, Wen Li, Sai-Yang Zhang
Publikováno v:
Molecules, Vol 26, Iss 16, p 4899 (2021)
The chalcone and quinoline scaffolds are frequently utilized to design novel anticancer agents. As the continuation of our work on effective anticancer agents, we assumed that linking chalcone fragment to the quinoline scaffold through the principle
Externí odkaz:
https://doaj.org/article/30cc84c1a9ea4e4ba893f04855a086f2
Autor:
Xu Liu, Xiao-Jing Pang, Yuan Liu, Wen-Bo Liu, Yin-Ru Li, Guang-Xi Yu, Yan-Bing Zhang, Jian Song, Sai-Yang Zhang
Publikováno v:
Molecules, Vol 26, Iss 13, p 4047 (2021)
Tubulin has been regarded as an attractive and successful molecular target in cancer therapy and drug discovery. Vicinal diaryl is a simple scaffold found in many colchicine site tubulin inhibitors, which is also an important pharmacophoric point of
Externí odkaz:
https://doaj.org/article/dab30dc0e5ca44a2b3e3d4a153556412
Autor:
Xiao-Jing Pang, Xiu-Juan Liu, Yuan Liu, Wen-Bo Liu, Yin-Ru Li, Guang-Xi Yu, Xin-Yi Tian, Yan-Bing Zhang, Jian Song, Cheng-Yun Jin, Sai-Yang Zhang
Publikováno v:
Molecules, Vol 26, Iss 14, p 4250 (2021)
FAK is a nonreceptor intracellular tyrosine kinase which plays an important biological function. Many studies have found that FAK is overexpressed in many human cancer cell lines, which promotes tumor cell growth by controlling cell adhesion, migrati
Externí odkaz:
https://doaj.org/article/57aac87141774f78808ca2a8f94f0955
Autor:
Wen-Bo Liu, Guang Xi Yu, Yong-Feng Guan, Jian Song, Yin Ru Li, Xiu-Juan Liu, Xiao-Jing Pang, Sai-Yang Zhang, Yan-Bing Zhang
Publikováno v:
Medicinal Chemistry Research. 30:1795-1821
Numerous antitumor drugs exhibited excellent anti-proliferation activities, discovered from natural products. Oridonin is isolated from a traditional Chinese medicine Isodon rubescens, and it exhibit various biological functions including anticancer,
Autor:
Jian Song, Sai-Yang Zhang, Jin-Bo Niu, Chun-Quan Hua, Cheng-Yun Jin, Jia-Jia Yang, Yan-Bing Zhang, Guang-Xi Yu, Yuan Liu, Ying-Qiu Qi, Yin-Ru Li
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1715-1731 (2021)
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1715-1731 (2021)
Hippo signalling pathway plays a crucial role in tumorigenesis and cancer progression. In this work, we identified an N-aryl sulphonamide-quinazoline derivative, compound 9i as an anti-gastric cancer agent, which exhibited potent antiproliferative ab
Autor:
Jian Song, Fang-Fang Liu, Yin-Ru Li, Wen-Bo Liu, Guang-Xi Yu, Xin-Yi Tian, Yan-Bing Zhang, Sai-Yang Zhang
Publikováno v:
SSRN Electronic Journal.
Autor:
Yin-Ru Li, Yan-Bing Zhang, Xin-Yi Tian, Cheng-Yun Jin, Yuan Liu, Xiao-Jing Pang, Xiu-Juan Liu, Sai-Yang Zhang, Jian Song, Wen-Bo Liu, Guang-Xi Yu
Publikováno v:
Molecules
Molecules, Vol 26, Iss 4250, p 4250 (2021)
Molecules, Vol 26, Iss 4250, p 4250 (2021)
FAK is a nonreceptor intracellular tyrosine kinase which plays an important biological function. Many studies have found that FAK is overexpressed in many human cancer cell lines, which promotes tumor cell growth by controlling cell adhesion, migrati