Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Guan-Sheng Liu"'
Autor:
Yin Zhang, Julie M Huynh, Guan-Sheng Liu, Richard Ballweg, Kayenat S Aryeh, Andrew L Paek, Tongli Zhang
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 9, p e1007158 (2019)
Chemotherapy resistance is a major challenge to the effective treatment of cancer. Thus, a systematic pipeline for the efficient identification of effective combination treatments could bring huge biomedical benefit. In order to facilitate rational d
Externí odkaz:
https://doaj.org/article/f501b1749c324b698edad8e4e09907c9
Publikováno v:
Stem Cells International, Vol 2016 (2016)
Cardiac regeneration is a homeostatic cardiogenic process by which the sections of malfunctioning adult cardiovascular tissues are repaired and renewed employing a combination of both cardiomyogenesis and angiogenesis. Unfortunately, while high-quali
Externí odkaz:
https://doaj.org/article/858ac338e24d46d384041c982dbe78f2
Autor:
Yin Zhang, Alan Ashbaugh, Tongli Zhang, Richard Ballweg, Guan-Sheng Liu, Joseph Facciolo, Melanie T. Cushion
Publikováno v:
BMC Systems Biology, Vol 13, Iss 1, Pp 1-7 (2019)
BMC Systems Biology
BMC Systems Biology
The yeast-like fungi Pneumocystis, resides in lung alveoli and can cause a lethal infection known as Pneumocystis pneumonia (PCP) in hosts with impaired immune systems. Current therapies for PCP, such as trimethoprim-sulfamethoxazole (TMP-SMX), suffe
Autor:
George Gardner, Evangelia G. Kranias, Guo-Chang Fan, Guan-Sheng Liu, Jiang Qian, Yutian Li, Nathan Robbins, Kobra Haghighi, Jack Rubinstein, Burns C. Blaxall, Min Jiang, Joshua G. Travers
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • PKA-phosphorylation of Hsp20 is elevated in human failing hearts. • Increases in phosphorylated Hsp20 in vivo are associated with fibrotic remodeling and reduced left ventricular function. • The phosphorylated
Highlights • PKA-phosphorylation of Hsp20 is elevated in human failing hearts. • Increases in phosphorylated Hsp20 in vivo are associated with fibrotic remodeling and reduced left ventricular function. • The phosphorylated
Autor:
Jack Rubinstein, Guan-Sheng Liu, Evangelia G. Kranias, Nathan Robbins, Sheryl E. Koch, Evan Onusko, Michael R. McDermott
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0230386 (2020)
PLoS ONE
PLoS ONE
Probenecid has been used for decades in the treatment of gout but recently has also been found to improve outcomes in patients with heart failure via stimulation of the transient receptor potential vanilloid 2 (TRPV2) channel in cardiomyocytes. This
Autor:
George Adly, Chi Keung Lam, Guan-Sheng Liu, Wenfeng Cai, George Gardner, Min Jiang, Evangelia G. Kranias, Fawzi Alogaili, Nathan Robbins, Jack Rubinstein
Publikováno v:
Journal of Cellular and Molecular Medicine
Heat shock protein 20 (Hsp20) has been shown to be a critical regulator of cardiomyocyte survival upon cardiac stress. In this study, we investigated the functional significance of a novel human Hsp20 mutation (S10F) in peripartum cardiomyopathy. Pre
Autor:
Xiang Gao, Ying-Lan Li, Guan-Sheng Liu, Wenfeng Cai, Yigang Wang, Lei Wang, Shi-Zheng Wu, Christian Paul, Lin Jiang, Boyu Wang
Publikováno v:
DNA and Cell Biology. 37:432-441
HCLS1 Associated Protein X-1 (HAX1) promotes cell survival through attenuation of the damaged signals from endoplasmic reticulum and mitochondria, which are known as prominent intracellular compartments for the autophagic process under stress conditi
Autor:
Elizabeth Vafiadaki, George Adly, Hongyan Zhu, Jack Rubinstein, Kobina Essandoh, George Gardner, Qiangrong Liang, Evangelia G. Kranias, Wenfeng Cai, Xiaohong Wang, Chi Keung Lam, Guan-Sheng Liu, Min Jiang, Kobra Haghighi, Despina Sanoudou, Guo-Chang Fan, Persoulla Nicolaou
Publikováno v:
Autophagy. 14:80-97
HSPB6/Hsp20 (heat shock protein family B [small] member 6) has emerged as a novel cardioprotector against stress-induced injury. We identified a human mutant of HSPB6 (HSPB6S10F) exclusively present in dilated cardiomyopathy (DCM) patients. Cardiac e
Autor:
Adam J. Pollak, Sandra E. Wiley, Philip Bidwell, Evangelia G. Kranias, Despina Sanoudou, Kobra Haghighi, Guan-Sheng Liu, Demetrios A. Arvanitis, Vivek P. Singh, Jack E. Dixon, David Gonzalez, Swati Kunduri
Publikováno v:
Proceedings of the National Academy of Sciences. 114:9098-9103
Precise Ca cycling through the sarcoplasmic reticulum (SR), a Ca storage organelle, is critical for proper cardiac muscle function. This cycling initially involves SR release of Ca via the ryanodine receptor, which is regulated by its interacting pro
Autor:
Darrell B. Newman, Takeshi Matsumoto, Hartzell V. Schaff, Alberto Hendler, Ayesha Ahmed, Alex Blatt, Lina Wen, Yujie Hong, Zhiyuan Jiang, Shuo Li, Christophe Bauters, Haseeb Ilias Basha, Subeer Wadia, Kohichiro Iwasaki, Zvi Vered, Patricia A. Pellikka, David Ho, Guirong Feng, Guoqiang Zhong, Anja Wiedswang Horjen, Sanami Kawada, Florence Pinet, Stephen Boateng, Ludmila Tsatskin, Joseph J. Maleszewski, Nikhil Warrier, Guan-Sheng Liu, Adam S. Budzikowski, Satz Mengensatzproduktion, Clifford J. Kavinsky, Druckerei Stückle, Liam Mullen, John Kassotis, Peizhen Sun, Shanshan Li, Heidi M. Connolly, William R. Miranda, Harald Arnesen, Shu Fang, Pål Smith, Damien Kenny, Frederick Frost, Ingebjørg Seljeflot, Jon Norseth, Aleem Khand, Arnljot Tveit, Pei Gee Chew, Sara R. Ulimoen, Eli Peleg, Sanjay Kumar, Michael Ghods, Ammar M. Killu, Marina Leitman
Publikováno v:
Cardiology. 133:I-V