SEAD reference panel with 22,134 haplotypes boosts rare variant imputation and genome-wide association analysis in Asian populations.

Autor: Yang MY; School of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China.; Center for Health and Data Science (CHDS), the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.; Diseases & Population (DaP) Geninfo Lab, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China., Zhong JD; Center for Health and Data Science (CHDS), the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.; Diseases & Population (DaP) Geninfo Lab, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China., Li X; School of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China.; Center for Health and Data Science (CHDS), the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.; Diseases & Population (DaP) Geninfo Lab, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China., Tian G; WBBC Shandong Center, Binzhou Medical University, Yantai, Shandong, China., Bai WY; Diseases & Population (DaP) Geninfo Lab, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China., Fang YH; WBBC Jiangxi Center, Jiangxi Medical College, Shangrao, Jiangxi, China., Qiu MC; WBBC Jiangxi Center, Jiangxi Medical College, Shangrao, Jiangxi, China., Yuan CD; Department of Dermatology, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang, China., Yu CF; Department of Orthopedic Surgery, Shangrao Municipal Hospital, Shangrao, Jiangxi, China., Li N; The High-Performance Computing Center, Westlake University, Hangzhou, Zhejiang, China., Yang JJ; The High-Performance Computing Center, Westlake University, Hangzhou, Zhejiang, China., Liu YH; The High-Performance Computing Center, Westlake University, Hangzhou, Zhejiang, China., Yu SH; Clinical Genome Center, KingMed Diagnostics, Co., Ltd, Guangzhou, Guangdong, China., Zhao WW; Clinical Genome Center, KingMed Diagnostics, Co., Ltd, Guangzhou, Guangdong, China., Liu JQ; Clinical Genome Center, KingMed Diagnostics, Co., Ltd, Guangzhou, Guangdong, China., Sun Y; Clinical Genome Center, KingMed Diagnostics, Co., Ltd, Guangzhou, Guangdong, China., Cong PK; Diseases & Population (DaP) Geninfo Lab, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China., Khederzadeh S; Diseases & Population (DaP) Geninfo Lab, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China., Zhao PP; Diseases & Population (DaP) Geninfo Lab, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China., Qian Y; Center for Health and Data Science (CHDS), the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.; Diseases & Population (DaP) Geninfo Lab, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China., Guan PL; School of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China.; Center for Health and Data Science (CHDS), the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.; Diseases & Population (DaP) Geninfo Lab, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China., Gu JX; School of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China.; Center for Health and Data Science (CHDS), the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.; Diseases & Population (DaP) Geninfo Lab, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China., Gai SR; School of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China.; Center for Health and Data Science (CHDS), the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.; Diseases & Population (DaP) Geninfo Lab, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China., Yi XJ; Diseases & Population (DaP) Geninfo Lab, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China., Tao JG; School of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China.; Center for Health and Data Science (CHDS), the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.; Diseases & Population (DaP) Geninfo Lab, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China., Chen X; Center for Health and Data Science (CHDS), the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.; Diseases & Population (DaP) Geninfo Lab, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China., Miao MM; Diseases & Population (DaP) Geninfo Lab, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China., Lei LX; Medical Biosciences, Imperial College London, London, United Kingdom., Xu L; WBBC Shandong Center, Binzhou Medical University, Yantai, Shandong, China., Xie SY; WBBC Shandong Center, Binzhou Medical University, Yantai, Shandong, China., Li JC; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.; Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.; Center for Medical Genetics & Hunan Key Laboratory, School of Life Sciences, Central South University, Changsha, Hunan, China., Guo JF; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.; Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.; Center for Medical Genetics & Hunan Key Laboratory, School of Life Sciences, Central South University, Changsha, Hunan, China., Karasik D; Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel., Yang L; Institute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China., Tang BS; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.; Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.; Center for Medical Genetics & Hunan Key Laboratory, School of Life Sciences, Central South University, Changsha, Hunan, China., Huang F; WBBC Shandong Center, Binzhou Medical University, Yantai, Shandong, China., Zheng HF; Center for Health and Data Science (CHDS), the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China. houf.zheng@suda.edu.cn.; Diseases & Population (DaP) Geninfo Lab, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China. houf.zheng@suda.edu.cn.

Publikováno v: Nature communications [Nat Commun] 2024 Dec 30; Vol. 15 (1), pp. 10839. Date of Electronic Publication: 2024 Dec 30.

Cohort profile: the Westlake BioBank for Chinese (WBBC) pilot project.

Autor: Zhu XW; Diseases & Population (DaP) Geninfo Lab, School of Lifesciences, Westlake University, Hangzhou, Zhejiang, China.; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Westlake University, Hangzhou, Zhejiang, China., Liu KQ; WBBC Jiangxi Center, Jiangxi Medical College, Shangrao, Jiangxi, China., Wang PY; WBBC Shandong Center, Binzhou Medical University, Yantai, Shandong, China., Liu JQ; Hangzhou Kingmed Diagnostics Co., Ltd, Hangzhou, Zhejiang, China., Chen JY; Zhejiang Healthfuture Institute for Cell-Based Applied Technology, Hangzhou, Zhejiang, China., Xu XJ; Jiading District Center for Disease Control and Prevention, Shanghai, China., Xu JJ; WBBC Jiangxi Center, Jiangxi Medical College, Shangrao, Jiangxi, China., Qiu MC; WBBC Jiangxi Center, Jiangxi Medical College, Shangrao, Jiangxi, China., Sun Y; Hangzhou Kingmed Diagnostics Co., Ltd, Hangzhou, Zhejiang, China., Liu C; Department of Health Management, Hangzhou Normal University, Hangzhou, Zhejiang, China., Bai WY; Diseases & Population (DaP) Geninfo Lab, School of Lifesciences, Westlake University, Hangzhou, Zhejiang, China.; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Westlake University, Hangzhou, Zhejiang, China., Zhao PP; Diseases & Population (DaP) Geninfo Lab, School of Lifesciences, Westlake University, Hangzhou, Zhejiang, China.; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China., Xia J; Diseases & Population (DaP) Geninfo Lab, School of Lifesciences, Westlake University, Hangzhou, Zhejiang, China.; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China., Gai SR; Diseases & Population (DaP) Geninfo Lab, School of Lifesciences, Westlake University, Hangzhou, Zhejiang, China.; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China., Guan PL; Diseases & Population (DaP) Geninfo Lab, School of Lifesciences, Westlake University, Hangzhou, Zhejiang, China.; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China., Qian Y; Diseases & Population (DaP) Geninfo Lab, School of Lifesciences, Westlake University, Hangzhou, Zhejiang, China.; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China., Cong PK; Diseases & Population (DaP) Geninfo Lab, School of Lifesciences, Westlake University, Hangzhou, Zhejiang, China.; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Westlake University, Hangzhou, Zhejiang, China., Xie SY; WBBC Shandong Center, Binzhou Medical University, Yantai, Shandong, China., Zheng HF; Diseases & Population (DaP) Geninfo Lab, School of Lifesciences, Westlake University, Hangzhou, Zhejiang, China zhenghoufeng@westlake.edu.cn.; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Westlake University, Hangzhou, Zhejiang, China.

Publikováno v: BMJ open [BMJ Open] 2021 Jun 28; Vol. 11 (6), pp. e045564. Date of Electronic Publication: 2021 Jun 28.