Výsledky vyhledávání - "Guan, Huiping"

Discovery of a First-in-Class Gut-Restricted RET Kinase Inhibitor as a Clinical Candidate for the Treatment of IBS

Publikováno v: ACS Medicinal Chemistry Letters. 9:623-628

[Image: see text] Abdominal pain and abnormal bowel habits represent major symptoms for irritable bowel syndrome (IBS) patients that are not adequately managed. Although the etiology of IBS is not completely understood, many of the functions of the g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f36b6eae6bd02c0507a8d63cf1a08053
https://doi.org/10.1021/acsmedchemlett.8b00035

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Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 25:5743-5747

The propensity for cancer cells to accumulate additional centrosomes relative to normal cells could be exploited for therapeutic benefit in oncology. Following literature reports that suggested TNKS1 (tankyrase 1) and PARP16 may be involved with spin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ef0c28dfded674f22b85a915cbb40f
https://doi.org/10.1016/j.bmcl.2015.10.079

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Discovery of novel Jak2–Stat pathway inhibitors with extended residence time on target

Autor: Jiaquan Wu, Jon Read, Shan Huang, Geraldine Bebernitz, Michael Zinda, Syeed Hussain, Marat Alimzhanov, Kirsten Bell, Nancy DeGrace, Michelle Lamb, Guan Huiping, Caroline Rivard, Stephanos Ioannidis, Minwei Ye, Bo Peng

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 23:3105-3110

The discovery of the activating mutation V617F in the JH2 domain of Jak2 and the modulation of oncogenic Stat3 by Jak2 inhibitors have spurred a great interest in the inhibition of the Jak2/Stat pathway in oncology. In this Letter, we communicate the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a6a2791a8a3f7af3ef48c74521912bf
https://doi.org/10.1016/j.bmcl.2013.02.111

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Replacement of pyrazol-3-yl amine hinge binder with thiazol-2-yl amine: Discovery of potent and selective JAK2 inhibitors

Autor: Geraldine Bebernitz, Marat Alimzhanov, Guan Huiping, Bo Peng, Lynsie Almeida, Kirsten Bell, Michelle Lamb, Stephanos Ioannidis, Michael Zinda

Publikováno v: Bioorganicmedicinal chemistry letters. 20(5)

Thiazol-2-yl amine was identified as an isosteric replacement for pyrazol-3-yl amine during our efforts to identify potent and selective JAK2 inhibitors. The rationale, synthesis and biological evaluation of several analogs is reported, along with th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e812ecbe28c5253a3ff835de1393b6f
https://pubmed.ncbi.nlm.nih.gov/20144546

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Assimilation and Integration of the Chinese students in Germany- a study based on the example from the Bremen University

Autor: Guan, Huiping

Seit den letzten Jahren ist die Anzahl chinesischer Studierender an deutschen Universitäten ständig zugenommen. Das Auslandsstudium bedeutet für die Betroffenen nicht nur Hoffnung und Zukunft, sondern auch viele Herausforderungen. Die Anpassung un

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https://media.suub.uni-bremen.de/handle/elib/2440

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