Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Guak-Kim Tan"'
Autor:
Guak-Kim Tan, Brian A Pryce, Anna Stabio, John V Brigande, ChaoJie Wang, Zheng Xia, Sara F Tufa, Douglas R Keene, Ronen Schweitzer
Publikováno v:
eLife, Vol 9 (2020)
Studies of cell fate focus on specification, but little is known about maintenance of the differentiated state. In this study, we find that the mouse tendon cell fate requires continuous maintenance in vivo and identify an essential role for TGFβ si
Externí odkaz:
https://doaj.org/article/08b49814dff4413798a4ba6fddbb0ae8
Autor:
Brandon D. Markway, Guak-Kim Tan, Gary Brooke, James E. Hudson, Justin J. Cooper-White, Michael R. Doran
Publikováno v:
Cell Transplantation, Vol 19 (2010)
Chondrogenesis of mesenchymal stem cells (MSCs) is typically induced when they are condensed into a single aggregate and exposed to transforming growth factor-β (TGF-β). Hypoxia, like aggregation and TGF-β delivery, may be crucial for complete cho
Externí odkaz:
https://doaj.org/article/62a2e9b1dfac49c2bbc9e992d7c486d4
Publikováno v:
Stem Cell Reports
Summary Understanding cell recruitment in damaged tendons is critical for improvements in regenerative therapy. We recently reported that targeted disruption of transforming growth factor beta (TGFβ) type II receptor in the tendon cell lineage (Tgfb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f453f6bdeeab848ab04187133375f29c
http://europepmc.org/articles/PMC8693658
http://europepmc.org/articles/PMC8693658
Understanding the role of cell recruitment in tendon disorders is critical for improvements in regenerative therapy. We recently reported that targeted disruption of TGFβ type II receptor in the tendon cell lineage (Tgfbr2ScxCre) resulted in tenocyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c3b851b57083f98a4aeb6f28e3410db
https://doi.org/10.1101/2020.11.11.378505
https://doi.org/10.1101/2020.11.11.378505
Autor:
Ronen Schweitzer, Chaojie Wang, John V. Brigande, Zheng Xia, Douglas R. Keene, Sara F. Tufa, Guak-Kim Tan, Brian A. Pryce, Anna Stabio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0d0aa0bfd6f0ccbe26d73103e007d1c
https://doi.org/10.7554/elife.52695.sa2
https://doi.org/10.7554/elife.52695.sa2
Autor:
Ronen Schweitzer, John V. Brigande, Chaojie Wang, Zheng Xia, Sara F. Tufa, Guak-Kim Tan, Douglas R. Keene, Anna Stabio, Brian A. Pryce
Studies of cell fate focus on specification, but little is known about maintenance of the differentiated state. We find that TGFβ signaling plays an essential role in maintenance of the tendon cell fate. To examine the role TGFβ signaling in tenocy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4cc72d8c4a08a37ab5bf0531332c7a4
https://doi.org/10.1101/823021
https://doi.org/10.1101/823021
Autor:
John V. Brigande, Zheng Xia, Guak Kim Tan, Anna Stabio, Brian A. Pryce, Sara F. Tufa, Douglas R. Keene, Ronen Schweitzer, Chaojie Wang
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Studies of cell fate focus on specification, but little is known about maintenance of the differentiated state. In this study, we find that the mouse tendon cell fate requires continuous maintenance in vivo and identify an essential role for TGFβ si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6757b1a996dfb6bb1c09aee278fe609d
https://pubmed.ncbi.nlm.nih.gov/31961320
https://pubmed.ncbi.nlm.nih.gov/31961320
Publikováno v:
Biomaterials. 32:5600-5614
Due to its limited healing potential within the inner avascular region, functional repair of the meniscus remains a significant challenge in orthopaedic surgery. Tissue engineering of a meniscus implant using meniscal cells offers the promise of enha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e85e87bc99cc54e7463608509d9c69c
https://doi.org/10.1016/j.biomaterials.2011.04.033
https://doi.org/10.1016/j.biomaterials.2011.04.033
Publikováno v:
Acta Biomaterialia. 7:2804-2816
Collagen II, a major extracellular matrix component in cartilaginous tissues, undergoes fibrillogenesis under physiological conditions. The present study explored collagen II fiber formation in solution and in two- (coverslip) and three-dimensional (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9558d0281aebcbba46fbc59dc786d8a
https://doi.org/10.1016/j.actbio.2011.03.022
https://doi.org/10.1016/j.actbio.2011.03.022
Autor:
Justin J. Cooper-White, Guak Kim Tan
Publikováno v:
Cell Adhesion & Migration. 5:220-226
Menisci are one of the most commonly injured parts of the knee. Conventional surgical interventions are often associated with a long-term increased risk of osteoarthritis. Meniscal tissue engineering utilizes natural or synthetic matrices as a scaffo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6b7fb3b94fa58f4c6de97fe6aeb90dd
https://doi.org/10.4161/cam.5.3.14463
https://doi.org/10.4161/cam.5.3.14463