Safety, immunogenicity, and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates

Autor: Stéphane Pillet, Prabhu S. Arunachalam, Guadalupe Andreani, Nadia Golden, Jane Fontenot, Pyone Pyone Aye, Katharina Röltgen, Gabrielle Lehmicke, Philipe Gobeil, Charlotte Dubé, Sonia Trépanier, Nathalie Charland, Marc-André D’Aoust, Kasi Russell-Lodrigue, Christopher Monjure, Robert V. Blair, Scott D. Boyd, Rudolf P. Bohm, Jay Rappaport, François Villinger, Nathalie Landry, Bali Pulendran, Brian J. Ward

Publikováno v: Cellular and Molecular Immunology

Although antivirals are important tools to control severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, effective vaccines are essential to control the current coronavirus disease 2019 (COVID-19) pandemic. Plant-derived virus-like

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::196ab61cd1a7251d30167a864e952c12
https://doi.org/10.1038/s41423-021-00809-2

Early Loss of Splenic Tfh Cells in SIV-Infected Rhesus Macaques.

Autor: Félicien Moukambi, Henintsoa Rabezanahary, Vasco Rodrigues, Gina Racine, Lynda Robitaille, Bernard Krust, Guadalupe Andreani, Calayselvy Soundaramourty, Ricardo Silvestre, Mireille Laforge, Jérôme Estaquier

Publikováno v: PLoS Pathogens, Vol 11, Iss 12, p e1005287 (2015)

Follicular T helper cells (Tfh), a subset of CD4 T lymphocytes, provide crucial help to B cells in the production of antigen-specific antibodies. Although several studies have analyzed the dynamics of Tfh cells in peripheral blood and lymph nodes (LN

Externí odkaz: https://doaj.org/article/02cb8889eb034f64b27ad3d64662f078

Leishmania infantum amastigotes trigger a subpopulation of human B cells with an immunoregulatory phenotype.

Autor: Guadalupe Andreani, Michel Ouellet, Rym Menasria, Alejandro Martin Gomez, Corinne Barat, Michel J Tremblay

Publikováno v: PLoS Neglected Tropical Diseases, Vol 9, Iss 2, p e0003543 (2015)

Visceral leishmaniasis is caused by the protozoan parasites Leishmania infantum and Leishmania donovani. This infection is characterized by an uncontrolled parasitization of internal organs which, when left untreated, leads to death. Disease progress

Externí odkaz: https://doaj.org/article/8fd72c7b4745441d80c07d0d6643bddb

Early Antiretroviral Therapy Prevents Viral Infection of Monocytes and Inflammation in Simian Immunodeficiency Virus-Infected Rhesus Macaques

Autor: Thibault Mesplèdes, Petronela Ancuta, Julien Clain, Ghita Benmadid-Laktout, Henintsoa Rabezanahary, Ouafa Zghidi-Abouzid, Gina Racine, Jérôme Estaquier, Chloé Borde, Guadalupe Andreani, Fabrizio Mammano

Publikováno v: Journal of Virology
Journal of Virology, American Society for Microbiology, 2020, 94 (22), pp.e01478-20. ⟨10.1128/JVI⟩
J Virol
Journal of Virology, 2020, 94 (22), pp.e01478-20. ⟨10.1128/JVI⟩

International audience; Despite early antiretroviral therapy (ART), treatment interruption is associated with viral rebound, indicating early viral reservoir (VR) seeding and absence of full eradication of human immunodeficiency virus type 1 (HIV-1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2caca4d956bddd1f1395207aab2172a0
https://www.hal.inserm.fr/inserm-03451855/document

Inhibition of HIV-1 replication in human monocyte-derived macrophages by parasite Trypanosoma cruzi.

Autor: Guadalupe Andreani, Ana M Celentano, María E Solana, Silvia I Cazorla, Emilio L Malchiodi, Liliana A Martínez Peralta, Guillermina L Dolcini

Publikováno v: PLoS ONE, Vol 4, Iss 12, p e8246 (2009)

BACKGROUND:Cells of monocyte/macrophage lineage are one of the major targets of HIV-1 infection and serve as reservoirs for viral persistence in vivo. These cells are also the target of the protozoa Trypanosoma cruzi, the causative agent of Chagas di

Externí odkaz: https://doaj.org/article/176c7f13f3a54a458618a8f59da7a705