Identification of BiP as a CB1 receptor-interacting protein that fine-tunes cannabinoid signaling in the mouse brain

Autor: David Martín-Gutiérrez, Ignacio Rodríguez-Crespo, Giovanni Marsicano, Joaquin Botta, Leyre Urigüen, José Sánchez-Prieto, Marc Espina, Rebeca Diez-Alarcia, Irene B. Maroto, Carlos Costas-Insua, Nuria García-Font, Raquel Bajo-Grañeras, Peter J. McCormick, Roser Cortés, Vicent Casadó, Andrea Ruiz-Calvo, Manuel Guzmán, Enric I. Canela, M. Teresa Vilaró, Ismael Galve-Roperh, Estefanía Moreno, Silvia Ginés, Guadalupe Mengod, Luigi Bellocchio, Ricardo Martín

Publikováno v: Journal of Neuroscience
Journal of Neuroscience, Society for Neuroscience, 2021, 41 (38), pp.7924-7941. ⟨10.1523/JNEUROSCI.0821-21.2021⟩
Addi. Archivo Digital para la Docencia y la Investigación
instname
Digital.CSIC. Repositorio Institucional del CSIC
Dipòsit Digital de la UB
Universidad de Barcelona

Cannabinoids, the bioactive constituents of cannabis, exert a wide array of effects on the brain by engaging Type 1 cannabinoid receptor (CB1R). Accruing evidence supports that cannabinoid action relies on context-dependent factors, such as the biolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c37fb9bb32a834bae66d420b7820be79
http://hdl.handle.net/2445/181159

Distribution of 5-HT receptors in the central nervous system: an update

Autor: Daniel Hoyer, Guadalupe Mengod, Roser Cortés, M T Vilaró

Almost 10 years have passed since we wrote the review on the “Distribution of 5-HT receptors in the central nervous system” in this series ( Mengod, Cortes, Vilaro, & Hoyer, 2010 ). The number of 5-HT receptors remains the same: 14 receptor subty

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc88681766268ab7ff6c3c5f0f73de94
https://doi.org/10.1016/b978-0-444-64125-0.00006-2

A preliminary investigation of phoshodiesterase 7 inhibitor VP3.15 as therapeutic agent for the treatment of experimental autoimmune encephalomyelitis mice

Autor: Rocío Martín-Álvarez, Valle Palomo, Guadalupe Mengod, Carmen Gil, Nuria Paul-Fernández, Ana Martínez

Publikováno v: Journal of Chemical Neuroanatomy. 80:27-36

cAMP plays a significant role in signal transduction pathways controlling multiple cellular processes such as inflammation and immune regulation. cAMP levels are regulated by a family of phosphodiesterases (PDEs). We have studied the effects of a nov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b0288f48ff1009df3748b9119457bf
https://doi.org/10.1016/j.jchemneu.2016.12.001

Comparative study of the expression of cholinergic system components in the CNS of experimental autoimmune encephalomyelitis mice: Acute vs remitting phase

Autor: Silvia Serrano-Acedo, Guadalupe Mengod, Ada Maria Tata, Valentina Gatta, Maria Di Bari, Samantha Sperduti, G. Pinto, Rocío Martín-Álvarez

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Acetylcholine (ACh) is involved in the modulation of the inflammatory response. ACh levels are regulated by its synthesizing enzyme, choline acetyltransferase (ChAT), and by its hydrolyzing enzymes, mainly acetylcholinesterase (AChE) and butyrylcholi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::762543a1141c5b1cb70e543a8972b859
http://hdl.handle.net/11573/1204187

Cholinergic system and neuroinflammation: implication in multiple sclerosis

Autor: Maria Di Bari, G. Pinto, Marcella Reale, Guadalupe Mengod, Ada Maria Tata

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

[Background] Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system (CNS) characterized by leucocytes infiltration, demyelination, axonal degeneration and neuronal death. Although the etiology of MS is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be70e1e30f05059d78c977dbfe58e10
http://hdl.handle.net/11573/961395