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Publisher Summary This chapter summarizes some of the methods available for the determination of internal sequence information of small amounts of proteins separated by polyacrylamide gel electrophoresis. The methods have in common that they are base
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67c1ee078c4be9d9917dde2348eac8a8
https://doi.org/10.1016/b978-0-12-058756-8.50015-8
https://doi.org/10.1016/b978-0-12-058756-8.50015-8
Autor:
Naomi Mihira, Misaki Sekiguchi, Kenichi Nagata, Takashi Saito, Toshio Ohshima, Kaori Sato, Hiroki Sasaguri, Takaomi C. Saido, Naoto Watamura, Ryo Fujioka
Publikováno v:
The Journal of Biological Chemistry
We previously developed single App knock-in mouse models of Alzheimer's disease (AD) harboring the Swedish and Beyreuther/Iberian mutations with or without the Arctic mutation (AppNL-G-F and AppNL-F mice, respectively). These models showed Aβ pathol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c901230fb3cfb1cf28cfd7fab0de79ae
https://doi.org/10.1016/j.jbc.2021.101004
https://doi.org/10.1016/j.jbc.2021.101004
Autor:
John R. Atack, Wei-Feng Xue, Louise C. Serpell, Ana Caroline Raulin, Youssra K. Al-Hilaly, John McGeehan, Lucas Kraft
Publikováno v:
Journal of Molecular Biology
Raulin, A-C, Kraft, L, Al-Hilaly, Y, Xue, W-F, McGeehan, J, Atack, J & Serpell, L C 2019, ' The molecular basis for Apolipoprotein E4 as the major risk factor for late onset Alzheimer's disease ', Journal of Molecular Biology, vol. 431, no. 12, pp. 2248-2265 . https://doi.org/10.1016/j.jmb.2019.04.019
Raulin, A-C, Kraft, L, Al-Hilaly, Y, Xue, W-F, McGeehan, J, Atack, J & Serpell, L C 2019, ' The molecular basis for Apolipoprotein E4 as the major risk factor for late onset Alzheimer's disease ', Journal of Molecular Biology, vol. 431, no. 12, pp. 2248-2265 . https://doi.org/10.1016/j.jmb.2019.04.019
Apolipoprotein E4 (ApoE4) is one of three (E2, E3 and E4) human isoforms of an α-helical, 299-amino-acid protein. Homozygosity for the ε4 allele is the major genetic risk factor for developing late-onset Alzheimer's disease (AD). ApoE2, ApoE3 and A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a9d6a9f7dcb0650d86ec70dd141851
http://sro.sussex.ac.uk/id/eprint/83616/7/1-s2.0-S0022283619302268-main.pdf
http://sro.sussex.ac.uk/id/eprint/83616/7/1-s2.0-S0022283619302268-main.pdf
Autor:
Andras Lukacs, András Kengyel, Elek Telek, Henriett Halász, Kristof Karadi, Beáta Bugyi, Miklós Nyitrai, József Kardos, Zsuzsanna Fekete
Publikováno v:
The Journal of Biological Chemistry
The lesser-known unconventional myosin 16 protein is essential in proper neuronal functioning and has been implicated in cell cycle regulation. Its longer Myo16b isoform contains a C-terminal tail extension (Myo16Tail), which has been shown to play a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61ea193c50307e98951fb7f431981c6b
https://doi.org/10.1016/j.jbc.2021.100716
https://doi.org/10.1016/j.jbc.2021.100716
Publikováno v:
Journal of Molecular Biology
Repeat proteins are formed from units of 20–40 aa that stack together into quasi one-dimensional non-globular structures. This modular repetitive construction means that, unlike globular proteins, a repeat protein's equilibrium folding and thus the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d5c41e13bfb955ec7037f0ccc89544ca
http://europepmc.org/articles/PMC4871810
http://europepmc.org/articles/PMC4871810
Autor:
Xu Shen, Shuying Peng, Jianhua Shen, Tao Sun, Liduo Yue, Fei Ye, Yuan Wang, Guo-wei Li, Hualiang Jiang, Jing Chen, Yiming Yang, Haibin Luo, Youhua Xie, Yi Du
Publikováno v:
Biophysical Chemistry
The major biochemical and thermodynamic features of nucelocapsid protein of SARS coronavirus (SARS_NP) were characterized by use of non-denatured gel electrophoresis, size-exclusion chromatographic and surface plasmon resonance (SPR) techniques. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c29348ea93d8ad1e888a9a45c47373ee
http://europepmc.org/articles/PMC7116930
http://europepmc.org/articles/PMC7116930
Autor:
Sakamoto, Sora1 (AUTHOR), Riku, Yuichi2,3 (AUTHOR), Nomura, Teiko Komori4 (AUTHOR), Kimura, Akio5 (AUTHOR), Yamahara, Naoki5 (AUTHOR), Ohuchi, Kazuki1 (AUTHOR), Yoshida, Mari2 (AUTHOR), Iwasaki, Yasushi2 (AUTHOR), Shimohata, Takayoshi5,6 (AUTHOR), Inden, Masatoshi1 (AUTHOR), Honda, Ryo4,6 (AUTHOR) ryohonda.rh@gmail.com
Publikováno v:
Translational Neurodegeneration. 10/8/2024, Vol. 13 Issue 1, p1-5. 5p.
Autor:
Arapidi, Georgij P.1,2 (AUTHOR) arapidi@gmail.com, Urban, Anatoly S.1,2 (AUTHOR), Osetrova, Maria S.1 (AUTHOR), Shender, Victoria O.1,2 (AUTHOR), Butenko, Ivan O.2,3 (AUTHOR), Bukato, Olga N.2 (AUTHOR), Kuznetsov, Alexandr A.2 (AUTHOR), Saveleva, Tatjana M.1 (AUTHOR), Nos, Grigorii A.1 (AUTHOR), Ivanova, Olga M.1,4 (AUTHOR), Lopukhov, Leonid V.5 (AUTHOR), Laikov, Alexander V.5 (AUTHOR), Sharova, Nina I.6 (AUTHOR), Nikonova, Margarita F.6 (AUTHOR), Mitin, Alexander N.6 (AUTHOR), Martinov, Alexander I.6 (AUTHOR), Grigorieva, Tatiana V.5 (AUTHOR), Ilina, Elena N.2,3 (AUTHOR), Ivanov, Vadim T.1 (AUTHOR), Govorun, Vadim M.1,2,3 (AUTHOR)
Publikováno v:
BMC Biology. 8/26/2024, Vol. 22 Issue 1, p1-21. 21p.
Publikováno v:
Biochimie
Type III galactosemia results from reduced activity of the enzyme UDP-galactose 4′-epimerase. Five disease-associated alleles (G90E, V94M, D103G, N34S and L183P) and three artificial alleles (Y105C, N268D, and M284K) were tested for their ability t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::337347e0300d78eaca08593005b28af5
https://pubmed.ncbi.nlm.nih.gov/21703329
https://pubmed.ncbi.nlm.nih.gov/21703329
Autor:
Liu, Hua1 (AUTHOR), Liu, Huina2,3 (AUTHOR) 948581537@qq.com, Yang, Qiubo1 (AUTHOR) qiuboyang2003@163.com, Fan, Zhipeng2,4,5 (AUTHOR) zpfan@ccmu.edu.cn
Publikováno v:
Stem Cell Research & Therapy. 6/18/2024, Vol. 15 Issue 1, p1-21. 21p.