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Akademický článek

Development and validation of a capillary electrophoresis method for the characterization of protegrin IB-367

Autor: Chen, Jie ^*, Fausnaugh-Pollitt, Jodi, Gu, Leo

Publikováno v: In Journal of Chromatography A 20 August 1999 853(1-2):197-206

MTX-cIBR Conjugate for Targeting Methotrexate to Leukocytes: Conjugate Stability and in vivo Efficacy in Suppressing Rheumatoid Arthritis

Autor: Majumdar, Sumit, Anderson, Meagan E., Xu, Christine R., Yakovleva, Tatyana V., Gu, Leo C., Malefyt, Thomas R., Siahaan, Teruna J.

Methotrexate (MTX) has been used to treat rheumatoid arthritis at low doses and leukemia at high doses; however, this drug can produce severe side effects. Our hypothesis is that MTX side effects can be attenuated by directing the drug to the target

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5c6474e72bc0807ba48334576c9999c9
https://europepmc.org/articles/PMC4474090/

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Degradation of 4′-azidothymidine in aqueous solution

Autor: Michael Brandl, T.W. Chan, Robert G. Strickley, Thomas Bregante, Gu Leo

Publikováno v: International Journal of Pharmaceutics. 93:75-83

The kinetics of the degradation of 4′-azidothymidine (ADRT) in aqueous solution from pH 1 to 11 were studied by reverse phase and ion exchange HPLC. The pH-rate profiles at 50, 60 and 80°C were U-shaped with the rate law of kobs = kHaH + kH2O + kO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c9ec4f393cbfe055661936975dffbd9f
https://doi.org/10.1016/0378-5173(93)90165-c

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