Zobrazeno 1 - 10
of 3 087
pro vyhledávání: '"Gsk-3β"'
Autor:
A. Markovska, K. Somers, J. Guillaume, J. Melief, A. P. Mazar, D. M. Schmitt, H. S. Schipper, M. Boes
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The prognosis of patients with high-risk neuroblastoma remains poor, partly due to inadequate immune recognition of the tumor. Neuroblastomas display extremely low surface MHC-I, preventing recognition by cytotoxic T lymphocytes (CTLs) and c
Externí odkaz:
https://doaj.org/article/2d883a7222ed4916b7cb4780cb1ff82d
Autor:
Dr. Öznur Eyilcim, Dr. Fulya Günay, Dr. Yuk Yin Ng, Dr. Özlem Ulucan Açan, Dr. Zuhal Turgut, Dr. Ömer Tahir Günkara
Publikováno v:
ChemistryOpen, Vol 13, Iss 12, Pp n/a-n/a (2024)
Abstract A series of novel maleimide derivatives were synthesized, with various heterocyclic compounds serving as side chains in the synthesis process. The structural characteristics of these compounds were elucidated through the application of 1H‐
Externí odkaz:
https://doaj.org/article/dabfc22e760c49e4a6bd8dc9d15c2c38
Publikováno v:
Pharmacological Research - Modern Chinese Medicine, Vol 13, Iss , Pp 100543- (2024)
Introduction: Alzheimer's disease (AD) accounts for the majority of dementia cases, characterized by a gradual decline in memory and cognitive functions. Traditional Chinese medicine (TCM) has a long history of treating AD and has proposed a series o
Externí odkaz:
https://doaj.org/article/a0695163fbe741ba99334479a668b99d
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Purpose Pancreatic cancer is a lethal malignancy with a grim prognosis. Previous studies have proven that Leucine Rich Repeat of Flightless-1 Interacting Protein 1 (LRRFIP1) plays a pivotal role in cell biological processes, while its clinic
Externí odkaz:
https://doaj.org/article/eff043d1a9eb4ff4866a85b055ca54e3
Publikováno v:
F1000Research, Vol 13 (2024)
Background The discovery of an ideal and effective therapy is urgently required for the treatment of Alzheimer’s disease. The main pathological hallmarks of Alzheimer’s disease that appear before the clinical symptoms are neurofibrillary tangles,
Externí odkaz:
https://doaj.org/article/850dcddb5ca34934bc35a260ba167507
Autor:
Jiageng Guo, Xinya Jiang, Jing Lian, Huaying Li, Fan Zhang, Jinling Xie, Jiagang Deng, Xiaotao Hou, Zhengcai Du, Erwei Hao
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
The PI3K/AKT/GSK-3β signaling pathway plays a pivotal role in numerous physiological and pathological processes, including cell proliferation, apoptosis, differentiation, and metabolic regulation. Aberrant activation of the PI3K/AKT pathway is intri
Externí odkaz:
https://doaj.org/article/3c84d6e9fdfc4cfe999ee9599ed7be00
Publikováno v:
F1000Research, Vol 13 (2024)
Background The discovery of an ideal and effective therapy is urgently required for the treatment of Alzheimer’s disease. The main pathological hallmarks of Alzheimer’s disease that appear before the clinical symptoms are neurofibrillary tangles,
Externí odkaz:
https://doaj.org/article/426077cfaff34ca9af4643809c5199de
Autor:
Congmin Wang, Yu Hei, Yu Liu, Akhilesh Kumar Bajpai, Yuhe Li, Yawen Guan, Fuyi Xu, Cuifang Yao
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
As a dietary strategy, methionine restriction has been reported to promote longevity and regulate metabolic disorders. However, the role and possible regulatory mechanisms underlying methionine in neurodegenerative diseases such as Alzheimer's diseas
Externí odkaz:
https://doaj.org/article/bcb6e7737a8b4d879f3aea2ed84a3ac6
Autor:
Noura Almusallam, Asma Alonazi, Anfal Bin Dayel, Abdullah Almubarak, Rizwan Ali, Wajd Althakfi, Rehab Ali, Nouf Alrasheed
Publikováno v:
Saudi Pharmaceutical Journal, Vol 32, Iss 7, Pp 102102- (2024)
Post-acute myocardial infarction (AMI) fibrosis is a pathophysiologic process characterised by activation of the profibrotic mediator, transforming growth factor-β (TGF-β). AMI is associated with a substantial increase in the levels of extracellula
Externí odkaz:
https://doaj.org/article/770b20693573475cb798de3d124875be
Publikováno v:
PeerJ, Vol 12, p e17538 (2024)
Background Gynostemma pentaphyllum (Thunb.) Makino, a well-known edible and medicinal plant, has anti-aging properties and is used to treataging-associated conditions such as diabetes, metabolic syndrome, and cardiovascular diseases. Gypenosides (GYP
Externí odkaz:
https://doaj.org/article/42c467da0a164b00b5de5c3caee53059