Acetylcholine receptor based chemogenetics engineered for neuronal inhibition and seizure control assessed in mice

Autor: Quynh-Anh Nguyen, Peter M. Klein, Cheng Xie, Katelyn N. Benthall, Jillian Iafrati, Jesslyn Homidan, Jacob T. Bendor, Barna Dudok, Jordan S. Farrell, Tilo Gschwind, Charlotte L. Porter, Annahita Keravala, G. Steven Dodson, Ivan Soltesz

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Abstract Epilepsy is a prevalent disorder involving neuronal network hyperexcitability, yet existing therapeutic strategies often fail to provide optimal patient outcomes. Chemogenetic approaches, where exogenous receptors are expressed in defined br

Externí odkaz: https://doaj.org/article/9991808b163e4d46b294196caba44f82

First-Generation Inference Accelerator Deployment at Facebook

Autor: Anderson, Michael, Chen, Benny, Chen, Stephen, Deng, Summer, Fix, Jordan, Gschwind, Michael, Kalaiah, Aravind, Kim, Changkyu, Lee, Jaewon, Liang, Jason, Liu, Haixin, Lu, Yinghai, Montgomery, Jack, Moorthy, Arun, Nadathur, Satish, Naghshineh, Sam, Nayak, Avinash, Park, Jongsoo, Petersen, Chris, Schatz, Martin, Sundaram, Narayanan, Tang, Bangsheng, Tang, Peter, Yang, Amy, Yu, Jiecao, Yuen, Hector, Zhang, Ying, Anbudurai, Aravind, Balan, Vandana, Bojja, Harsha, Boyd, Joe, Breitbach, Matthew, Caldato, Claudio, Calvo, Anna, Catron, Garret, Chandwani, Sneh, Christeas, Panos, Cottel, Brad, Coutinho, Brian, Dalli, Arun, Dhanotia, Abhishek, Duncan, Oniel, Dzhabarov, Roman, Elmir, Simon, Fu, Chunli, Fu, Wenyin, Fulthorp, Michael, Gangidi, Adi, Gibson, Nick, Gordon, Sean, Hernandez, Beatriz Padilla, Ho, Daniel, Huang, Yu-Cheng, Johansson, Olof, Juluri, Shishir, Kanaujia, Shobhit, Kesarkar, Manali, Killinger, Jonathan, Kim, Ben, Kulkarni, Rohan, Lele, Meghan, Li, Huayu, Li, Huamin, Li, Yueming, Liu, Cynthia, Liu, Jerry, Maher, Bert, Mallipedi, Chandra, Mangla, Seema, Matam, Kiran Kumar, Mehta, Jubin, Mehta, Shobhit, Mitchell, Christopher, Muthiah, Bharath, Nagarkatte, Nitin, Narasimha, Ashwin, Nguyen, Bernard, Ortiz, Thiara, Padmanabha, Soumya, Pan, Deng, Poojary, Ashwin, Ye, Qi, Raginel, Olivier, Rajagopal, Dwarak, Rice, Tristan, Ross, Craig, Rotem, Nadav, Russ, Scott, Shah, Kushal, Shan, Baohua, Shen, Hao, Shetty, Pavan, Skandakumaran, Krish, Srinivasan, Kutta, Sumbaly, Roshan, Tauberg, Michael, Tzur, Mor, Verma, Sidharth, Wang, Hao, Wang, Man, Wei, Ben, Xia, Alex, Xu, Chenyu, Yang, Martin, Zhang, Kai, Zhang, Ruoxi, Zhao, Ming, Zhao, Whitney, Zhu, Rui, Mathews, Ajit, Qiao, Lin, Smelyanskiy, Misha, Jia, Bill, Rao, Vijay

In this paper, we provide a deep dive into the deployment of inference accelerators at Facebook. Many of our ML workloads have unique characteristics, such as sparse memory accesses, large model sizes, as well as high compute, memory and network band

Externí odkaz: http://arxiv.org/abs/2107.04140

Knowledge Graph Embedding using Graph Convolutional Networks with Relation-Aware Attention

Autor: Sheikh, Nasrullah, Qin, Xiao, Reinwald, Berthold, Miksovic, Christoph, Gschwind, Thomas, Scotton, Paolo

Knowledge graph embedding methods learn embeddings of entities and relations in a low dimensional space which can be used for various downstream machine learning tasks such as link prediction and entity matching. Various graph convolutional network m

Externí odkaz: http://arxiv.org/abs/2102.07200

Autumn migration of the migrant hawker (Aeshna mixta) at the Baltic coast

Autor: Yvonne Oelmann, Diana Fiedler, Rune Michaelis, Meelis Leivits, Andreas Braun, Philipp Gschwind, Harald Neidhardt, Christoph Willigalla

Publikováno v: Movement Ecology, Vol 11, Iss 1, Pp 1-9 (2023)

Abstract Background Migratory insects are important for the provision of ecosystem services both at the origin and destination sites but – apart from some iconic species – the migration routes of many insect species have not been assessed. Coastl

Externí odkaz: https://doaj.org/article/fa43231d55bf45e6a123c5b49eb8907f

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