Zobrazeno 1 - 10
of 2 231
pro vyhledávání: '"Gs alpha subunit"'
Autor:
Burcu Yucel, Saniye Ada
Publikováno v:
Turkish Journal of Hematology. 39:22-28
Low glutamine levels have been shown in tumor environments for several cancer subtypes. Therefore, it has been suggested that cancer cells rewire their metabolism to adopt low nutrient levels for survival and proliferation. Although glutamine is a no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::061b4a689ba98fac9cfce8b55585d8c4
https://doi.org/10.4274/tjh.galenos.2021.2021.0054
https://doi.org/10.4274/tjh.galenos.2021.2021.0054
Autor:
Sarah J. Piper, Xin Zhang, Christopher J. Langmead, Patrick M. Sexton, Radostin Danev, Rachel M. Johnson, Teresa H. Vandekolk, Denise Wootten, Theodore J. Nettleton
Publikováno v:
Biochemical and Biophysical Research Communications. 578:84-90
Dual agonists that can activate both the glucagon-like peptide-1 receptor (GLP-1R) and the gastric inhibitory polypeptide receptor (GIPR) have demonstrated high efficacy for the treatment of metabolic disease. Peptide-19 is a prototypical dual agonis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ac9a2f200cf87384e80ba3421a510a2
https://doi.org/10.1016/j.bbrc.2021.09.016
https://doi.org/10.1016/j.bbrc.2021.09.016
Autor:
Joel R. Meyerson, Richard K Hite, Edward T. Eng, Jian-Shu Lou, Jianyun Huang, Kelsey D. Jordan, Xin-Yun Huang, Minfei Su, Kamela O. Alegre, Navid Paknejad
Publikováno v:
Nat Struct Mol Biol
The β1-adrenergic receptor (β1-AR) can activate two families of G proteins. When coupled to Gs, β1-AR increases cardiac output, and coupling to Gi leads to decreased responsiveness in myocardial infarction. By comparative structural analysis of tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbbaffe1f5d6ad2bd526fed3095666b2
https://doi.org/10.1038/s41594-021-00679-2
https://doi.org/10.1038/s41594-021-00679-2
Autor:
Dana J. Ramms, J. Silvio Gutkind, Francesco Raimondi, Friedrich W. Herberg, Nadia Arang, Susan S. Taylor
Publikováno v:
Pharmacological Reviews. 73:1326-1368
Many of the fundamental concepts of signal transduction and kinase activity are attributed to the discovery and crystallization of cAMP-dependent protein kinase, or protein kinase A. PKA is one of the best-studied kinases in human biology, with empha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2602f0cf5757a0645cfcb91024f638fc
https://doi.org/10.1124/pharmrev.120.000269
https://doi.org/10.1124/pharmrev.120.000269
Autor:
Sarah Paisdzior, Jörg Bürger, Michal Szczepek, Daniel Hilger, Brian Bauer, Annette G. Beck-Sickinger, T. Hilal, Anja Koch, Nicolas A. Heyder, Christian M. T. Spahn, Magdalena Schacherl, Peter Kühnen, Heike Biebermann, Dennis Kwiatkowski, Andrea Schmidt, Monique Gallandi, David Speck, Peter W. Hildebrand, Thorsten Mielke, Brian K. Kobilka, Gunnar Kleinau, Patrick Scheerer
Publikováno v:
Cell Research
The melanocortin-4 receptor (MC4R), a hypothalamic master regulator of energy homeostasis and appetite, is a class A G-protein-coupled receptor and a prime target for the pharmacological treatment of obesity. Here, we present cryo-electron microscopy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e3cac4619722e65c3857cb94f1c7078
https://doi.org/10.1038/s41422-021-00569-8
https://doi.org/10.1038/s41422-021-00569-8
FSH mediated cAMP signalling upregulates the expression of Gα subunits in pubertal rat Sertoli cells
Autor:
Alka Gupta, Indrashis Bhattacharya, Bhola Shankar Pradhan, Souvik Sen Sharma, Hironmoy Sarkar, Subeer S. Majumdar
Publikováno v:
Biochemical and Biophysical Research Communications. 569:100-105
Follicle Stimulating Hormone (FSH) acts via FSH-Receptor (FSH-R) by employing cAMP as the dominant secondary messenger in testicular Sertoli cells (Sc) to support spermatogenesis. Binding of FSH to FSH-R, results the recruitment of the intracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22e6d58c329eb62b7e6d4d20287cdbad
https://doi.org/10.1016/j.bbrc.2021.06.094
https://doi.org/10.1016/j.bbrc.2021.06.094
Publikováno v:
Journal of Molecular Endocrinology
The calcium-sensing receptor (CaSR) is a G protein-coupled receptor that plays a fundamental role in extracellular calcium (Ca2+e) homeostasis by regulating parathyroid hormone release and urinary calcium excretion. The CaSR has been described to act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e15b4b32a8603327fe8356c28185897
https://doi.org/10.1530/jme-21-0058
https://doi.org/10.1530/jme-21-0058
Publikováno v:
Journal of the American Chemical Society. 143:11044-11051
G-Protein-coupled receptors (GPCRs) belong to an important family of integral membrane receptor proteins that are essential for a variety of transmembrane signaling process, such as vision, olfaction, and hormone responses. They are also involved in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dec034d188759ada74367866b4fd24ff
https://doi.org/10.1021/jacs.1c03696
https://doi.org/10.1021/jacs.1c03696
Autor:
Hong Sun, Lili Sang, Hongyuan Zhang, Matthew James Turley, Zhiwei Zhao, Xide Hu, Hongjian Hou, Lijuan Wu, Tingting Zhang, Dongye Li, Lin Han, Jeremiah Ong'achwa Machuki, Lu Fu, Sian E. Harding
Publikováno v:
Journal of Endocrinology. 249:209-222
Currently, there are no conventional treatments for stress-induced cardiomyopathy (SCM, also known as Takotsubo syndrome), and the existing therapies are not effective. The recently discovered G protein-coupled estrogen receptor (GPER) executes the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5409eb98740d74b376cfe9ab38a50c6e
https://doi.org/10.1530/joe-20-0451
https://doi.org/10.1530/joe-20-0451
Autor:
Hak Joong Kim, Jieon Lee, Yakdol Cho, Doyoung Kim, Soyeon Lee, Rina Kwag, Hyunah Choo, Byungsun Jeon, Jiwan Woo, Jeongjin Kim
Publikováno v:
Journal of Medicinal Chemistry. 64:7453-7467
There has been significant attention concerning the biased agonism of G protein-coupled receptors (GPCRs), and it has resulted in various pharmacological benefits. 5-HT7R belongs to a GPCR, and it is a promising pharmaceutical target for the treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::222bb0c78b6fc5cb891c45d06839f699
https://doi.org/10.1021/acs.jmedchem.1c00110
https://doi.org/10.1021/acs.jmedchem.1c00110