Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Grzegorz Skibinski"'
Autor:
Jeremy C Parker, Isobel Douglas, Jennifer Bell, David Comer, Keith Bailie, Grzegorz Skibinski, Liam G Heaney, Michael D Shields
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129546 (2015)
Epithelial remodelling in asthma is characterised by goblet cell hyperplasia and mucus hypersecretion for which no therapies exist. Differentiated bronchial air-liquid interface cultures from asthmatic children display high goblet cell numbers. Epide
Externí odkaz:
https://doaj.org/article/fe4e892ac2054e788c6d572b009fadad
Autor:
Surendran Thavagnanam, Jeremy C Parker, Michael E McBrien, Grzegorz Skibinski, Michael D Shields, Liam G Heaney
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85802 (2014)
INTRODUCTION: Differentiated paediatric epithelial cells can be used to study the role of epithelial cells in asthma. Nasal epithelial cells are easier to obtain and may act as a surrogate for bronchial epithelium in asthma studies. We assessed the s
Externí odkaz:
https://doaj.org/article/30cfb9520c024ddc9b8dd4615c104011
Publikováno v:
Clinical and Developmental Immunology, Vol 6, Iss 3-4, Pp 273-284 (1998)
Externí odkaz:
https://doaj.org/article/6e5ec0034113475c888ffb3739736a89
Autor:
Jeremy C Parker, Surendran Thavagnanam, Grzegorz Skibinski, Jeremy Lyons, Jennifer Bell, Liam G Heaney, Michael D Shields
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e61023 (2013)
Asthma is a chronic inflammatory disease characterised by airways remodelling. In mouse models IL-9 and IL-13 have been implicated in airways remodelling including mucus hypersecretion and goblet cell hyperplasia. Their role, especially that of IL-9,
Externí odkaz:
https://doaj.org/article/5bb2d40dc8944e4ba251ac5f51bc8b24
Autor:
Isobel Douglas, Remi Villenave, Ultan F. Power, Liam G Heaney, Surendran Thavagnanam, Peter V. Coyle, Grzegorz Skibinski, JC Parker, James P. McKaigue, Severine Sarlang, Michael D. Shields
Publikováno v:
Proceedings of the National Academy of Sciences. 109:5040-5045
Respiratory syncytial virus (RSV) is the major viral cause of severe pulmonary disease in young infants worldwide. However, the mechanisms by which RSV causes disease in humans remain poorly understood. To help bridge this gap, we developed an ex viv
Autor:
Liam G Heaney, Michael E. McBrien, Grzegorz Skibinski, JC Parker, Michael D. Shields, Surendran Thavagnanam
Publikováno v:
Results in Immunology. 2:104-111
BackgroundIL-31 is a novel cytokine that has been implicated in allergic diseases such as atopic dermatitis and more recently asthma. While IL-31 has been well studied in skin conditions such as atopic dermatitis, little is known about the role IL-31
Glucocorticoid receptor β and histone deacetylase 1 and 2 expression in the airways of severe asthma
Autor:
Liam G Heaney, T. J. Warke, Peter Bradding, Richard Carter, Grzegorz Skibinski, Cliff Taggart, Stephen McQuaid, Sinéad Weldon, David F. Choy, Joe Arron, Lorcan McGarvey, Claire A. Butler
Publikováno v:
Thorax. 67:392-398
Rationale Upregulation of glucocorticoid receptor β (GRβ) has been implicated in steroid resistance in severe asthma, although previous studies are conflicting. GRβ has been proposed as a dominant negative isoform of glucocorticoid receptor α (GR
Cytopathogenesis of Sendai Virus in Well-Differentiated Primary Pediatric Bronchial Epithelial Cells
Autor:
Ultan F. Power, Severine Sarlang, James P. McKaigue, Peter V. Coyle, Olivier Touzelet, Surendran Thavagnanam, Grzegorz Skibinski, Michael D. Shields, Remi Villenave, Liam G Heaney, JC Parker
Publikováno v:
Journal of Virology. 84:11718-11728
Sendai virus (SeV) is a murine respiratory virus of considerable interest as a gene therapy or vaccine vector, as it is considered nonpathogenic in humans. However, little is known about its interaction with the human respiratory tract. To address th
Autor:
Tara Moore, Severine Sarlang, Rik L. de Swart, Grzegorz Skibinski, Linda J. Rennick, Stephen McQuaid, Martin Ludlow, W. Paul Duprex
Publikováno v:
Journal of General Virology, 91, 971-979. Microbiology Society
The lymphotropic and myelotropic nature of wild-type measles virus (wt-MV) is well recognized, with dendritic cells and lymphocytes expressing the MV receptor CD150 mediating systemic spread of the virus. Infection of respiratory epithelial cells has
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 293:L69-L76
Proliferation of bronchial epithelial cells is an important biological process in physiological conditions and various lung diseases. The objective of this study was to determine how bronchial fibroblasts influence bronchial epithelial cell prolifera